Výsledky vyhledávání - "Naruhito Higo"

Effect of Combination of Low-Frequency Sonophoresis or Electroporation with Iontophoresis on the Mannitol Flux or Electroosmosis through Excised Skin

Autor: Hiroaki Todo, Kenji Sugibayashi, Seiji Tokumoto, Naruhito Higo

Publikováno v: Biological & Pharmaceutical Bulletin. 39:1206-1210

In vitro permeation studies of mannitol were conducted across excised hairless mouse skin to determine and compare the enhancing effect of electroporation (EP) or sonophoresis (SP) combined with iontophoresis (IP) on the electroosmotic flow, and to a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3744a34a3926a90c89dc19a3c53f536
https://doi.org/10.1248/bpb.b15-00696

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Once-daily oxybutynin patch improves nocturia and sleep quality in Japanese patients with overactive bladder: Post-hoc analysis of a phase III randomized clinical trial

Autor: Osamu Ishizuka, Masaki Yoshida, Narihito Seki, Naruhito Higo, Hidenao Minami, Satoru Takahashi, Osamu Yamaguchi, Osamu Yokoyama, Yu Masegi, Tomonori Yamanishi, Akito Yamaguchi

Publikováno v: International Journal of Urology. 22:684-688

Objectives To investigate the efficacy of a once-daily oxybutynin patch for nocturia, and its influence on sleep quality in patients with overactive bladder. Methods We carried out post-hoc analysis of a phase III, randomized, double-blind, comparati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::caf4aea96410a06c028ef5d07eebfbeb
https://doi.org/10.1111/iju.12755

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Efficacy and safety of once-daily oxybutynin patch versus placebo and propiverine in Japanese patients with overactive bladder: A randomized double-blind trial

Autor: Shigeo Kobayashi, Hidenao Minami, Eiji Uchida, Osamu Yamaguchi, Naruhito Higo, Hiroyuki Sato

Publikováno v: International Journal of Urology. 21:586-593

Objectives To evaluate the efficacy and safety of once-daily oxybutynin patch therapy for overactive bladder. Methods A randomized double-blind trial was carried out in patients with overactive bladder syndrome, who received an oxybutynin patch, prop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a0f1ada7814c666d52e2b1fc33df59de
https://doi.org/10.1111/iju.12372

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Effect of electroporation and pH on the iontophoretic transdermal delivery of human insulin

Autor: Seiji Tokumoto, Naruhito Higo, Kenji Sugibayashi

Publikováno v: International Journal of Pharmaceutics. 326:13-19

The synergistic effect of electroporation (EP) and iontophoresis (IP) on the in vivo percutaneous absorption of human insulin was evaluated in rats. Passive diffusion and IP alone (0.4 mA/cm(2)) resulted in almost no skin permeation of insulin at pH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14632223d07c8fc2de0f923f7113ee92
https://doi.org/10.1016/j.ijpharm.2006.07.002

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Effect of electroporation on the electroosmosis across hairless mouse skin in vitro

Autor: Kenji Sugibayashi, Seiji Tokumoto, Kenji Mori, Naruhito Higo

Publikováno v: Journal of Controlled Release. 105:296-304

The effect of electroporation on the iontophoresis-produced electroosmosis across the skin was evaluated by measuring the permeability of hairless mouse skin, to mannitol, a non-electrolyte, in vitro. Immediately after electroporation by squared puls

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dc039c492df646eff9e544716e01614
https://doi.org/10.1016/j.jconrel.2005.04.002

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Once-daily oxybutynin patch improves nocturia and sleep quality in Japanese patients with overactive bladder: Post-hoc analysis of a phase III randomized clinical trial

Autor: Osamu, Yokoyama, Akito, Yamaguchi, Masaki, Yoshida, Tomonori, Yamanishi, Osamu, Ishizuka, Narihito, Seki, Satoru, Takahashi, Osamu, Yamaguchi, Naruhito, Higo, Hidenao, Minami, Yu, Masegi

Publikováno v: International journal of urology : official journal of the Japanese Urological Association. 22(7)

To investigate the efficacy of a once-daily oxybutynin patch for nocturia, and its influence on sleep quality in patients with overactive bladder.We carried out post-hoc analysis of a phase III, randomized, double-blind, comparative study in which an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2128c94f81014e8aa6650dfb3842fc00
https://pubmed.ncbi.nlm.nih.gov/25782032

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Optimum Dose of Once-Daily Oxybutynin Patch in Japanese Patients with Overactive Bladder: A Randomized Double-Blind Trial Versus Placebo

Autor: Osamu, Yamaguchi, Eiji, Uchida, Naruhito, Higo, Hidenao, Minami, Shigeo, Kobayashi, Hiroyuki, Sato

Publikováno v: Lower urinary tract symptoms. 8(3)

To evaluate the efficacy, safety, and optimum dose of once-daily oxybutynin patch for overactive bladder.A randomized double-blind trial was conducted in patients with overactive bladder symptoms for ≥24 weeks, who received an oxybutynin patch (73.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0586bad8b3ee400e29b3e613753eff56
https://pubmed.ncbi.nlm.nih.gov/27619779

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Iontophoretic pulsatile transdermal delivery of human parathyroid hormone (1–34)

Autor: Naruhito Higo, Tunehiko Fukuda, Yukihiro Matsumoto, Yasuaki Ogawa, Yasuyuki Suzuki, Katsumi Iga, Hirotoshi Adachi, Shigeo Yanai, Masahiro Kawase

Publikováno v: Journal of Pharmacy and Pharmacology. 53:1227-1234

Iontophoretic pulsatile transdermal delivery of hPTH(1–34) was examined in Sprague-Dawley (SD) rats, hairless rats and beagle dogs. Application for 60 min (200 μ 0.1 mA cm−2) showed current-responsive increases in serum hPTH(1–34) levels in al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a114dfa167784ca5a7c0eead43a9e13d
https://doi.org/10.1211/0022357011776676

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