Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Naruhisa Ota"'
Autor:
Jordan S. Mar, Naruhisa Ota, Nick D. Pokorzynski, Yutian Peng, Allan Jaochico, Dewakar Sangaraju, Elizabeth Skippington, Annemarie N. Lekkerkerker, Michael E. Rothenberg, Man-Wah Tan, Tangsheng Yi, Mary E. Keir
Publikováno v:
Microbiome, Vol 11, Iss 1, Pp 1-17 (2023)
Abstract Background IL-22 is induced by aryl hydrocarbon receptor (AhR) signaling and plays a critical role in gastrointestinal barrier function through effects on antimicrobial protein production, mucus secretion, and epithelial cell differentiation
Externí odkaz:
https://doaj.org/article/07f3567e2214401ab5134a8634835824
Autor:
Sigrid Noreng, Naruhisa Ota, Yonglian Sun, Hoangdung Ho, Matthew Johnson, Christopher P. Arthur, Kellen Schneider, Isabelle Lehoux, Christopher W. Davies, Kyle Mortara, Kit Wong, Dhaya Seshasayee, Matthieu Masureel, Jian Payandeh, Tangsheng Yi, James T. Koerber
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
NADPH oxidase NOX2 produces superoxide, a reactive oxygen species essential in innate immunity. Here, the authors reveal the structure of the NOX2 core, rationalize disease-causing mutations, and suggest avenues for selective NOX2 pharmacological mod
Externí odkaz:
https://doaj.org/article/d13cff7b590548a384f3e3bb6a259cd4
Autor:
David L. Lin, Varun N. Kapoor, Naruhisa Ota, Joseph Chavarria-Smith, Christian Cox, Menno van Lookeren Campagne, Travis W. Bainbridge, Noelyn M. Kljavin, Keith R. Anderson, Joseph R. Arron, Frederic J. de Sauvage, Shannon J. Turley, Yun Li, Søren Warming, Elaine E. Storm, Lifen Wang, Merone Roose-Girma
Publikováno v:
Science Immunology. 6
Repair of the intestinal epithelium is tightly regulated to maintain homeostasis. The response after epithelial damage needs to be local and proportional to the insult. How different types of damage are coupled to repair remains incompletely understo
Autor:
Wenjun Ouyang, Arivazhagan Sambandam, Rajita Pappu, Nadia Martinez-Martin, Jason A. Hackney, Vladimir Ramirez-Carrozzi, Kit Wong, Naruhisa Ota
Publikováno v:
The Journal of Immunology. 202:1935-1941
IL-17 family cytokines are critical to host defense responses at cutaneous and mucosal surfaces. Whereas IL-17A, IL-17F, and IL-17C induce overlapping inflammatory cascades to promote neutrophil-mediated immunity, IL-17E/IL-25 drives type 2 immune pa
Inflammatory Bowel Disease Susceptibility Gene C1ORF106 Regulates Intestinal Epithelial Permeability
Autor:
Ryan Ichikawa, Roger Caothien, Paolo Manzanillo, Arthur Wuster, Naruhisa Ota, Alexis Scherl, Gabriela Alvarado, Meron Roose-Girma, Youngsu Kwon, Mary E. Keir, Tangsheng Yi, Søren Warming, Brent S. McKenzie, Bingbing Dai, Wenjun Ouyang, Benjamin Haley, Maria Mouchess
Publikováno v:
ImmunoHorizons. 2:164-171
Intestinal epithelial cells form a physical barrier that is tightly regulated to control intestinal permeability. Proinflammatory cytokines, such as TNF-α, increase epithelial permeability through disruption of epithelial junctions. The regulation o
Autor:
Meredith Sagolla, Cara Skon-Hegg, Wyne P. Lee, Arthur Wuster, John G. Monroe, Timothy W. Behrens, Xiumin Wu, Juan Zhang, Patrick Caplazi, Jennifer Tom, Nandhini Ramamoorthi, Emma Doran, Naruhisa Ota
Both common and rare genetic variants of laccase domain-containing 1 (LACC1, previously C13orf31) are associated with inflammatory bowel disease, leprosy, Behcet disease, and systemic juvenile idiopathic arthritis. However, the functional relevance o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ff8b767cbd71b31de02ed6fc8bd2d87
https://europepmc.org/articles/PMC6305794/
https://europepmc.org/articles/PMC6305794/
Autor:
Paolo, Manzanillo, Maria, Mouchess, Naruhisa, Ota, Bingbing, Dai, Ryan, Ichikawa, Arthur, Wuster, Benjamin, Haley, Gabriela, Alvarado, Youngsu, Kwon, Roger, Caothien, Meron, Roose-Girma, Soren, Warming, Brent S, McKenzie, Mary E, Keir, Alexis, Scherl, Wenjun, Ouyang, Tangsheng, Yi
Publikováno v:
ImmunoHorizons. 2(5)
Intestinal epithelial cells form a physical barrier that is tightly regulated to control intestinal permeability. Proinflammatory cytokines, such as TNF-α, increase epithelial permeability through disruption of epithelial junctions. The regulation o
Autor:
J M Bates, S Ho, Jiabing Ding, Scot D. Liu, Naruhisa Ota, Søren Warming, K Flanagan, Merone Roose-Girma, Lian Mo, Lauri Diehl
Publikováno v:
Mucosal Immunology
Dendritic cells (DCs) form an extensive network in the intestinal lamina propria, which orchestrates the mucosal immune response. Alterations in DC function can predispose to inflammatory bowel disease, although by unknown mechanisms. We show that CD
Autor:
Ross Francis, Domagoj Vucic, Kajal Hamidzhadeh, Kate Senger, Andres Paler-Martinez, Naruhisa Ota, Kai H. Barck, Zhiyu Huang, Joseph Guillory, Surinder Jeet, Merone Roose-Girma, Lucinda Tam, Michael J. Townsend, Jason DeVoss, Richard A.D. Carano, Jason A. Hackney, Wyne P. Lee, Yonglian Sun, Vivian W. C. Lau, Brent S. McKenzie, Jenna L. Collier, A. Francesca Setiadi, Søren Warming, Connie Ha, Claire Emson, Jeremy Stinson, Victoria Pham, Patricia W. Grigg, Jennie R. Lill, Eugene Varfolomeev, Vladimir Ramirez-Carrozzi, Cesar A. Corzo, Youngsu Kwon, Zora Modrusan, Patrick Caplazi, Ali A. Zarrin, Anna Pham, Ivan Peng
Publikováno v:
Science Signaling. 10
Tumor progression locus 2 (TPL2; also known as MAP3K8) is a mitogen-activated protein kinase (MAPK) kinase kinase (MAP3K) that phosphorylates the MAPK kinases MEK1 and MEK2 (MEK1/2), which, in turn, activate the MAPKs extracellular signal-regulated k
Autor:
Naruhisa Ota, Patricia A. Valdez, Tao Sai, Sascha Rutz, Robert Soriano, Andrew Sebrell, Ivan Peng, Jiabing Ding, Zora Modrusan, Patrick Caplazi, Celine Eidenschenk, Jason A. Hackney, Kit Wong, Wenjun Ouyang, Rongze Lu, Jason DeVoss, Rajkumar Noubade
Publikováno v:
Nature. 509:235-239
The leucine-rich repeat protein NRROS which resides in the endoplasmic reticulum regulates phagocytic NADPH oxidase, minimizing collateral tissue damage caused by reactive oxygen species during inflammatory processes.