Zobrazeno 1 - 10
of 135
pro vyhledávání: '"Narsimha Reddy, Penthala"'
Autor:
Samuel Kakraba, Srinivas Ayyadevara, Nirjal Mainali, Meenakshisundaram Balasubramaniam, Suresh Bowroju, Narsimha Reddy Penthala, Ramani Atluri, Steven W. Barger, Sue T. Griffin, Peter A. Crooks, Robert J. Shmookler Reis
Publikováno v:
Pharmaceuticals, Vol 16, Iss 10, p 1498 (2023)
Chronic, low-grade inflammation has been implicated in aging and age-dependent conditions, including Alzheimer’s disease, cardiomyopathy, and cancer. One of the age-associated processes underlying chronic inflammation is protein aggregation, which
Externí odkaz:
https://doaj.org/article/5ef6117e54514590994189c991ada0a2
Autor:
Meenakshisundaram Balasubramaniam, Srinivas Ayyadevara, Akshatha Ganne, Samuel Kakraba, Narsimha Reddy Penthala, Xiuxia Du, Peter A. Crooks, Sue T. Griffin, Robert J. Shmookler Reis
Publikováno v:
iScience, Vol 20, Iss , Pp 248-264 (2019)
Summary: Diagnosis of neurodegenerative diseases hinges on “seed” proteins detected in disease-specific aggregates. These inclusions contain diverse constituents, adhering through aberrant interactions that our prior data indicate are nonrandom.
Externí odkaz:
https://doaj.org/article/9112be5150c14d7ca547e7c09ae2fb86
Autor:
Samuel Kakraba, Srinivas Ayyadevara, Narsimha Reddy Penthala, Meenakshisundaram Balasubramaniam, Akshatha Ganne, Ling Liu, Ramani Alla, Shoban Babu Bommagani, Steven W. Barger, W. Sue T. Griffin, Peter A. Crooks, Robert J. Shmookler Reis
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
Age-progressive neurodegenerative pathologies, including Alzheimer’s disease (AD), are distinguished and diagnosed by disease-specific components of intra- or extra-cellular aggregates. Increasing evidence suggests that neuroinflammation promotes p
Externí odkaz:
https://doaj.org/article/cd8ee4a5406445f280f7e037bc9a4a4b
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications, Vol 72, Iss 5, Pp 652-655 (2016)
(Z)-5-[2-(Benzo[b]thiophen-2-yl)-1-(3,5-dimethoxyphenyl)ethenyl]-1H-tetrazole methanol monosolvate, C19H16N4O2S·CH3OH, (I), was prepared by the reaction of (Z)-3-(benzo[b]thiophen-2-yl)-2-(3,5-dimethoxyphenyl)acrylonitrile with tributyltin azide via
Externí odkaz:
https://doaj.org/article/5da9ec9faf144fbeac0ff258a96c11e4
Autor:
John P Moore II, Soma Shekar Dachavaram, Shobanbabu Bommagani, Narsimha Reddy Penthala, Priya Venkatraman, E. Johan Foster, Peter A. Crooks, Jamie A. Hestekin
Publikováno v:
Molecules, Vol 25, Iss 8, p 1847 (2020)
The 2,2,6,6-tetramethylpiperidin-1-oxyl (TEMPO) oxidation of cellulose, when mediated with Oxone® (KHSO5), can be performed simply and under mild conditions. Furthermore, the products of the reaction can be isolated into two major components: Oxone
Externí odkaz:
https://doaj.org/article/04326525d9204d5399abb1b5ee7037b3
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications, Vol 71, Iss 10, Pp 1147-1150 (2015)
The title compounds, C26H28N2, (I), and C28H32N2, (II), were designed based on the structure of the potent α9α10 nicotinic acetylcholine receptor antagonist ZZ161C {1,1′-[[1,1′-biphenyl]-4,4′-diylbis(prop-2-yne-3,1-diyl)]bis(3,4-dimethylpyrid
Externí odkaz:
https://doaj.org/article/62fc45b7b88041c29fc48d9e819cf80b
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications, Vol 71, Iss 10, Pp 1132-1135 (2015)
As part of a comprehensive program to discover α9α10 nicotinic acetylcholine receptor antagonists, the title compounds C30H36N2, (I), and C36H48N2, (II), were synthesized by coupling 4,4′-bis(3-bromoprop-1-yn-1-yl)-1,1′-biphenyl with 4-methylpi
Externí odkaz:
https://doaj.org/article/62abdeb5c0b54bfda480afd0c6ceb3a5
Autor:
Narsimha Reddy Penthala, Nikhil Reddy Madadi, Shobanbabu Bommagani, Sean Parkin, Peter A. Crooks
Publikováno v:
Acta Crystallographica Section E, Vol 70, Iss 11, Pp 392-395 (2014)
The title compound, C19H17N3O3S (I), was prepared by a [3 + 2]cycloaddition azide condensation reaction using sodium azide and l-proline as a Lewis base catalyst. N-Methylation of compound (I) using CH3I gave compound (II), C20H19N3O3S. The benzothio
Externí odkaz:
https://doaj.org/article/ce281d44e6794c01830abda69376dfc7
Autor:
Narsimha Reddy Penthala, Peter A. Crooks, Mark S. Smeltzer, Ginell R. Post, Shobanbabu Bommagani, Zaineb A.F. Albayati
Publikováno v:
Toxicology Reports
Toxicology Reports, Vol 8, Iss, Pp 359-364 (2021)
Toxicology Reports, Vol 8, Iss, Pp 359-364 (2021)
Graphical abstract
Previous studies have demonstrated that the bone targeting agent BT2-peg2 (BT2-minipeg2, 9), when conjugated to vancomycin and delivered systemically by intravenous (IV) or intraperitoneal (IP) injection accumulates in bone to
Previous studies have demonstrated that the bone targeting agent BT2-peg2 (BT2-minipeg2, 9), when conjugated to vancomycin and delivered systemically by intravenous (IV) or intraperitoneal (IP) injection accumulates in bone to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::059f2b5101e3ad8933e56eabb203750f
https://doi.org/10.1016/j.toxrep.2021.02.002
https://doi.org/10.1016/j.toxrep.2021.02.002
Autor:
Narsimha Reddy Penthala, Peter A. Crooks, Paul L. Prather, Alexander H. Williams, Chang-Guo Zhan, Jing-Fang Yang
Publikováno v:
ACS Chem Neurosci
The cannabinoid (CB) receptors (CB(1)R and CB(2)R) represent a promising therapeutic target for several indications such as nociception and obesity. The ligands with non-selectivity can be traced to the high similarity in the binding sites of both ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24d0d1f828ec772eaac24d36d4b40282
https://doi.org/10.1021/acschemneuro.0c00551
https://doi.org/10.1021/acschemneuro.0c00551