Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Narsimha R. Munagala"'
Autor:
Narsimha R. Munagala, Ching C. Wang
Publikováno v:
Molecular and Biochemical Parasitology. 127:143-149
Trichomonas vaginalis, a parasitic protozoan and the causative agent of trichomoniasis, lacks de novo purine nucleotide synthesis and possesses a unique purine salvage pathway, consisting of a bacterial type purine nucleoside phosphorylase and a puri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::158c9df13cfcb6f1c356636cd0d736d1
https://doi.org/10.1016/s0166-6851(02)00330-4
https://doi.org/10.1016/s0166-6851(02)00330-4
Autor:
Narsimha R. Munagala, Ching C. Wang
Publikováno v:
Biochemistry. 41:10382-10389
Trichomonas vaginalis is a parasitic protozoan and the causative agent of trichomoniasis. Its primary purine salvage system, consisting of a purine nucleoside phosphorylase (PNP) and a purine nucleoside kinase, presents potential targets for designin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b28461420e7d4b1eba5412a416444dea
https://doi.org/10.1021/bi026025n
https://doi.org/10.1021/bi026025n
Autor:
Narsimha R. Munagala, Ching C. Wang
Publikováno v:
Molecular Microbiology. 44:1073-1079
Giardia lamblia is an anaerobic binucleate flagellated protozoan known to lack de novo synthesis of purine nucleotides. Our previous metabolic studies indicated two major parallel pathways mediated by adenine phosphoribosyltransferase (APRT) and guan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f52f9bd25063e740570cc80ec06c07b2
https://doi.org/10.1046/j.1365-2958.2002.02942.x
https://doi.org/10.1046/j.1365-2958.2002.02942.x
Publikováno v:
European Journal of Biochemistry. 259:565-571
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97632fc40dff9a211a9408b0ee248960
https://doi.org/10.1111/j.1432-1033.1996.00697.x
https://doi.org/10.1111/j.1432-1033.1996.00697.x
Publikováno v:
Antimicrobial Agents and Chemotherapy. 45:2571-2576
Parasitic protozoa lack the ability to synthesize purine nucleotides de novo, relying instead on purine salvage enzymes for their survival. Guanine phosphoribosyltransferase (GPRT) from the protozoan parasite Giardia lamblia is a potential target for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::814439092869a32bd2fd8c0c95231f3b
https://doi.org/10.1128/aac.45.9.2571-2576.2001
https://doi.org/10.1128/aac.45.9.2571-2576.2001
Autor:
Vern L. Schramm, Richard H. Furneaux, Steven C. Almo, Narsimha R. Munagala, Caroline M. Li, Ching C. Wang, Peter C. Tyler, Charles Grubmeyer, Wuxian Shi
Publikováno v:
Biochemistry. 39:6781-6790
Giardia lamblia, the protozoan parasite responsible for giardiasis, requires purine salvage from its host for RNA and DNA synthesis. G. lamblia expresses an unusual purine phosphoribosyltransferase with a high specificity for guanine (GPRTase). The e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4c3f898e1044de2d1f01695673ba576
https://doi.org/10.1021/bi000128t
https://doi.org/10.1021/bi000128t
Publikováno v:
Biochemistry. 39:4684-4691
All parasitic protozoa lack the ability to synthesize purine nucleotides de novo, relying instead on purine salvage enzymes for their survival. Hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT) from the protozoan parasite Tritrichomona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd21d342d9460da46948b5809265d99a
https://doi.org/10.1021/bi992555g
https://doi.org/10.1021/bi992555g
Autor:
Ching C. Wang, Narsimha R. Munagala
Publikováno v:
Biochemistry. 37:16612-16619
The hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRTase) from Tritrichomonas foetus has been proven to be a target for potential anti-tritrichomonial chemotherapy. Using a structure-based approach, the base-binding region of the active
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f16af35a0bc168d8a07f5b5439cf6a05
https://doi.org/10.1021/bi9818974
https://doi.org/10.1021/bi9818974
Publikováno v:
Biochemistry. 40(14)
The hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRTase), a type I PRTase, from Tritrichomonas foetus, is a potential target for antitritrichomonal chemotherapy. Structural data on all the type I PRTases reveal a highly flexible, 11-14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed647e33be001680e85e413273fa5995
https://pubmed.ncbi.nlm.nih.gov/11284686
https://pubmed.ncbi.nlm.nih.gov/11284686
Autor:
Irwin D. Kuntz, Connie M. Oshiro, Robert J. Fletterick, Solomon Mpoke, A. Geoffrey SkillmanJr., Ronald M. A. Knegtel, Ching C. Wang, Shinichi Katakura, John R. Somoza, Narsimha R. Munagala
Publikováno v:
Molecular Modeling and Prediction of Bioactivity ISBN: 9781461368571
Most protozoan parasites, such as Leishmania, Plasmodium, Toxoplasma and Trypanosoma, rely on a salvage pathway for their supply of purine ribonucleotides (Wang, 1984). Inhibition of this pathway therefore presents an interesting approach in the figh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71ca296113e4619b0ae3f7dae4560421
https://doi.org/10.1007/978-1-4615-4141-7_86
https://doi.org/10.1007/978-1-4615-4141-7_86
