Výsledky vyhledávání - "Narsimha R Nayini"

Cardiac arrest and resuscitation: Brain iron delocalization during reperfusion

Autor: Blaine C White, Raywin R Huang, Steven D. Aust, Carolynn L Zonia, Richard J Indreri, Gary S Krause, Ann Marie Garritano, Kathleen Joyce, A. Thomas Evans, Narsimha R Nayini, Thomas J Hoehner

Publikováno v: Annals of Emergency Medicine. 14:1037-1043

We hypothesize that brain injury from cardiac arrest occurs during reperfusion and is in part mediated by iron-dependent lipid peroxidation. We conducted a study to examine the time course of brain iron delocalization and lipid peroxidation in an ani

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eb167206176099d62ca21ded9ab2de2
https://doi.org/10.1016/s0196-0644(85)80915-x

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Natural course of iron delocalization and lipid peroxidation during the first eight hours following a 15-minute cardiac arrest in dogs

Autor: Gary S. Krause, Steven D. Aust, Ann Marie Garritano, Narsimha R Nayini, Blaine C. White, Thomas J Hoenher, Brian J. O'Neil

Publikováno v: Annals of Emergency Medicine. 16:1200-1205

Lipid peroxidation is thought to be a major contributing factor in neurological injury following cardiac arrest. Because iron availability is a prerequisite for lipid peroxidation, this experiment was designed to examine the natural time course of ir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dc42ecd44c25b752bc61ec3b36bea5b
https://doi.org/10.1016/s0196-0644(87)80224-x

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Myocardial tissue iron delocalization and evidence for lipid peroxidation after two hours of ischemia

Autor: Steven D. Aust, Steven Holt, Blaine C White, Carolyn Zonia, Narsimha R Nayini, Mark Gunderson, George F Eyster, Gary S Krause, Ann Marie Garitano, Kathleen Joyce

Publikováno v: Annals of Emergency Medicine. 15:1155-1159

Ischemic tissue injury has been proposed to be in part due to oxygen-radical-mediated lipid peroxidation. In vitro studies of such reactions show that they are thermodynamically unfavorable unless catalyzed by transitional metals such as iron in low

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7026c8ea6cd7ec0bb93e52106a4e48dc
https://doi.org/10.1016/s0196-0644(86)80857-5

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Ultrastructural and ionic studies in global ischemic dog brain

Autor: Gary S Krause, Narsimha R Nayini, Kusum Kumar, M. Goosmann, R. Estrada, Blaine C White, Adalbert Koestner, T. J. Hoehner

Publikováno v: Acta Neuropathologica. 73:393-399

A time course of tissue ionic changes, and their relation to ultrastructural findings during reperfusion following a 15-min global ischemic brain insult was studied in a dog model. Parietal cortex was analyzed for Ca, Na, K, Mg and Fe in controls and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07b6d979e2217e2789bbab8eb613c350
https://doi.org/10.1007/bf00688266

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Brain cortex tissue Ca, Mg, Fe, Na, and K following resuscitation from cardiac arrest in dogs

Autor: Kusum Kumar, Brian J. O'Neil, Blaine C. White, Robert A. Dilorenzo, Gary S. Krause, Raywin R Huang, John Koehler, Ann Marie Garritano, Steven D. Aust, Thomas J Hoehner, Narsimha R Nayini

Publikováno v: The American journal of emergency medicine. 5(1)

Recent evidence suggests that ultimate neurologic injury following cardiac arrest and resuscitation may be largely determined by biochemical events occurring during reperfusion. To test this hypothesis and further characterize the time course of some

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50e43aaaed619af4a58dca77addd6653
https://pubmed.ncbi.nlm.nih.gov/3814277

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Effect on biochemical markers of brain injury of therapy with deferoxamine or superoxide dismutase following cardiac arrest

Autor: Steven D. Aust, Narsimha R Nayini, Gary G March, James S Bicknell, Mark Goosmann, Blaine C. White, Gary S. Krause

Publikováno v: The American journal of emergency medicine. 6(6)

Iron-mediated lipid peroxidation by oxygen radical mechanisms is thought to be a contributing factor to neurological injury during reperfusion following resuscitation from cardiac arrest. This study was designed to examine and compare the effects of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9664e54238205a09870e4e49c41ad75
https://pubmed.ncbi.nlm.nih.gov/3178948

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Post resuscitation iron delocalization and malondialdehyde production in the brain following prolonged cardiac arrest

Autor: RJ Indrieri, William A. Jacobs, A. Thomas Evans, Steven D. Aust, Howard Bialek, Raywin R. Huang, James S Komara, Blaine C White, Narsimha R Nayini

Publikováno v: Journal of free radicals in biologymedicine. 1(2)

Assays for brain tissue malondialdehyde (MDA) and low molecular weight chelated (LMWC) iron were used to examine samples of the cerebral cortex obtained from dogs 2 h after resuscitation from a 15-min cardiac arrest. The effect of post-resuscitation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81fb2c4d07cef211abb5c3c3e4e94227
https://pubmed.ncbi.nlm.nih.gov/3836237

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Brain iron delocalization and lipid peroxidation following cardiac arrest

Autor: William A. Jacobs, A. Thomas Evans, Thomas J Hoehner, Raywin R Huang, Gary S. Krause, James S Komara, RJ Indrieri, Ann Marie Garritano, Blaine C. White, Howard A Bialick, Steven D. Aust, Narsimha R Nayini

Publikováno v: Annals of emergency medicine. 15(4)

Brain injury after cardiac arrest and resuscitation may occur, in part, by oxygen radical mechanisms. The availability of a transition metal, such as iron, is essential for in vitro initiation of this type of reaction. The brain has significant store

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffc6c554e5a33cd0e3ffab9489b80a21
https://pubmed.ncbi.nlm.nih.gov/3954169

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