Isoform-selective HDAC1/6/8 inhibitors with an imidazo-ketopiperazine cap containing stereochemical diversity

Autor: Lecointre, Bertrand, Narozny, Remy, Borrello, Maria Teresa, Senger, Johanna, Chakrabarti, Alokta, Jung, Manfred, Marek, Martin, Romier, Christophe, Melesina, Jelena, Sippl, Wolfgang, Bischoff, Laurent, Ganesan, A.

Publikováno v: Philosophical Transactions: Biological Sciences, 2018 Jun 01. 373(1748), 1-7.

Externí odkaz: https://www.jstor.org/stable/26486268

Design and synthesis of novel classes of HDACs and KMTs inhibitors

Autor: Narozny, Remy

For long, scientists thought that our body was driven only by our genetic code that we inherited at birth. However, this determinism was shattered entirely and proven as false in the second half of the 21st century with the discovery of epigenetics.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1366::8be3cd1a7d06502f91f06063a4a31885
https://ueaeprints.uea.ac.uk/71385/

Isoform-selective HDAC1/6/8 inhibitors with an imidazo-ketopiperazine cap containing stereochemical diversity.

Autor: Lecointre B; Normandie University, INSA Rouen, UNIROUEN, CNRS, COBRA (UMR 6014), 76000 Rouen, France., Narozny R; School of Pharmacy, University of East Anglia, Norwich NR4 7TJ, UK., Borrello MT; INSERM U1068 Cellular Stress Group, Cancer Research Center of Marseille, Parc scientifique de Luminy, 163 avenue de Luminy, 13288 Marseille Cedex 9, France., Senger J; Institut für Pharmazeutische Wissenschaften, Albert-Ludwigs-Universität Freiburg, Albertstraße 25, Freiburg 79104, Germany., Chakrabarti A; Institut für Pharmazeutische Wissenschaften, Albert-Ludwigs-Universität Freiburg, Albertstraße 25, Freiburg 79104, Germany., Jung M; Institut für Pharmazeutische Wissenschaften, Albert-Ludwigs-Universität Freiburg, Albertstraße 25, Freiburg 79104, Germany., Marek M; Département de Biologie Structurale Intégrative, Institut de Génétique et Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg, CNRS, INSERM, 1 rue Laurent Fries, 67404 Illkirch Cedex, France., Romier C; Département de Biologie Structurale Intégrative, Institut de Génétique et Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg, CNRS, INSERM, 1 rue Laurent Fries, 67404 Illkirch Cedex, France., Melesina J; Institute of Pharmacy, Martin-Luther University of Halle-Wittenberg, 06120 Halle/Saale, Germany., Sippl W; Institute of Pharmacy, Martin-Luther University of Halle-Wittenberg, 06120 Halle/Saale, Germany., Bischoff L; Normandie University, INSA Rouen, UNIROUEN, CNRS, COBRA (UMR 6014), 76000 Rouen, France., Ganesan A; School of Pharmacy, University of East Anglia, Norwich NR4 7TJ, UK a.ganesan@uea.ac.uk.

Publikováno v: Philosophical transactions of the Royal Society of London. Series B, Biological sciences [Philos Trans R Soc Lond B Biol Sci] 2018 Jun 05; Vol. 373 (1748).