Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Narottam, Acharya"'
Autor:
Bhabasha Gyanadeep Utkalaja, Shraddheya Kumar Patel, Satya Ranjan Sahu, Abinash Dutta, Narottam Acharya
Publikováno v:
mBio, Vol 15, Iss 10 (2024)
ABSTRACT DNA polymerase ε (Polε) is an essential replicative polymerase consisting of Pol2, Dpb2, Dpb3, and Dpb4 subunits and has not been explored in the pathogenic yeast Candida albicans. C. albicans is accountable for >40% of deaths due to syste
Externí odkaz:
https://doaj.org/article/7a65ca77fdbf43d880b232a912af2f3a
Autor:
Satya Ranjan Sahu, Abinash Dutta, Doureradjou Peroumal, Premlata Kumari, Bhabasha Gyanadeep Utakalaja, Shraddheya Kumar Patel, Narottam Acharya
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 6, Pp 1254-1283 (2024)
Abstract Disseminated fungal infections account for ~1.5 million deaths per year worldwide, and mortality may increase further due to a rise in the number of immunocompromised individuals and drug-resistance fungal species. Since an approved antifung
Externí odkaz:
https://doaj.org/article/b93bc1c0f9664b2b9dc23a43d020d6e8
Publikováno v:
eLife, Vol 13 (2024)
Despite current antifungal therapy, invasive candidiasis causes >40% mortality in immunocompromised individuals. Therefore, developing an antifungal vaccine is a priority. Here, we could for the first time successfully attenuate the virulence of Cand
Externí odkaz:
https://doaj.org/article/1ff0dacc6043431aa5c4e020bcde8d6e
Autor:
Shraddheya Kumar Patel, Satya Ranjan Sahu, Bhabasha Gyanadeep Utkalaja, Swagata Bose, Narottam Acharya
Publikováno v:
Gut Microbes, Vol 15, Iss 1 (2023)
ABSTRACTCandida albicans is a pathobiont that inflicts serious bloodstream fungal infections in individuals with compromised immunity and gut dysbiosis. Genomic diversity in the form of copy number alteration, ploidy variation, and loss of heterozygo
Externí odkaz:
https://doaj.org/article/4096e3b998dd4ba995d0f0ba7a9d723f
Publikováno v:
Journal of Fungi, Vol 10, Iss 3, p 222 (2024)
The incidence of infections caused by Candida species, specifically by drug-resistant isolates, is a major health concern as they can disseminate to and colonize most vital organs, enhancing morbidity and mortality. Several molecular mechanisms have
Externí odkaz:
https://doaj.org/article/f3403095b96443f3a6d63c619d0b6e4e
Autor:
Satya Ranjan Sahu, Shweta Thakur, Doureradjou Peroumal, Bhabasha Gyanadeep Utkalaja, Abinash Dutta, Premlata Kumari, Ipsita Subhadarsini, Narottam Acharya
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
4-Nitroquinoline N-oxide (4-NQO) and its derivatives react with genomic DNA to form stable quinolone monoadducts, which are highly mutagenic and genotoxic. While the chronic high-dose exposure of epithelial cells to a carcinogen such as 4-NQO leads t
Externí odkaz:
https://doaj.org/article/b2c206f1a0b34090be16b413996bc2b8
Autor:
Doureradjou Peroumal, Satya Ranjan Sahu, Premlata Kumari, Bhabasha Gyanadeep Utkalaja, Narottam Acharya
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 5 (2022)
ABSTRACT Candida albicans survives as a commensal fungus in the gastrointestinal tract, and that its excessive growth causes infections in immunosuppressed individuals is widely accepted. However, any mutualistic relationship that may exist between C
Externí odkaz:
https://doaj.org/article/a79d0309c15f4bcf934dcb18c1b26412
Autor:
Satya Ranjan Sahu, Swagata Bose, Manish Singh, Premlata Kumari, Abinash Dutta, Bhabasha Gyanadeep Utkalaja, Shraddheya Kumar Patel, Narottam Acharya
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Candidiasis is a mycosis caused by opportunistic Candida species. The occurrence of fungal infections has considerably increased in the last few years primarily due to an increase in the number of immune-suppressed individuals. Alarming bloodstream i
Externí odkaz:
https://doaj.org/article/3238cda19b4d4db5aeb3da941c744618
Publikováno v:
Microbial Cell, Vol 7, Iss 12, Pp 312-322 (2020)
Extracellular vesicles (EV), also known as membrane vesicles, are produced as an end product of secretion by both pathogenic and non-pathogenic bacteria. Several reports suggest that archaea, gram-negative bacteria, and eukaryotic cells secrete membr
Externí odkaz:
https://doaj.org/article/1736bd03a91241fb966b83c16b930454
Publikováno v:
Journal of Fungi, Vol 9, Iss 3, p 286 (2023)
Humans are colonized by diverse populations of microbes. Infections by Candida albicans, an opportunistic fungal pathogen, are a result of imbalances in the gut microbial ecosystem and are due to the suppressed immunity of the host. Here, we explored
Externí odkaz:
https://doaj.org/article/79926660961042c6989a27d89c364ece