Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Naroa, Serna"'
Autor:
Rita Sala, Elisa Rioja-Blanco, Naroa Serna, Laura Sánchez-García, Patricia Álamo, Lorena Alba-Castellón, Isolda Casanova, Antonio López-Pousa, Ugutz Unzueta, María Virtudes Céspedes, Esther Vázquez, Antonio Villaverde, Ramon Mangues
Publikováno v:
Drug Delivery, Vol 29, Iss 1, Pp 1384-1397 (2022)
Colorectal cancer (CRC) remains the third cause of cancer-related mortality in Western countries, metastases are the main cause of death. CRC treatment remains limited by systemic toxicity and chemotherapy resistance. Therefore, nanoparticle-mediated
Externí odkaz:
https://doaj.org/article/cd8cbc74b6b642dead764be19bd723bb
Autor:
Carlos Martínez-Torró, Lorena Alba-Castellón, Luis Miguel Carrasco-Díaz, Naroa Serna, Laura Imedio, Alberto Gallardo, Isolda Casanova, Ugutz Unzueta, Esther Vázquez, Ramón Mangues, Antonio Villaverde
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 164, Iss , Pp 114976- (2023)
Two human proteins involved in the inflammatory cell death, namely Gasdermin D (GSDMD) and the Mixed Lineage Kinase Domain-Like (MLKL) protein have been engineered to accommodate an efficient ligand of the tumoral cell marker CXCR4, and a set of addi
Externí odkaz:
https://doaj.org/article/0ce3b8f034ce46aba99a76e5fc14a68d
Autor:
Elisa Rioja-Blanco, Irene Arroyo-Solera, Patricia Álamo, Isolda Casanova, Alberto Gallardo, Ugutz Unzueta, Naroa Serna, Laura Sánchez-García, Miquel Quer, Antonio Villaverde, Esther Vázquez, Ramon Mangues, Lorena Alba-Castellón, Xavier León
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 5, Pp 2578-2591 (2022)
Loco-regional recurrences and distant metastases represent the main cause of head and neck squamous cell carcinoma (HNSCC) mortality. The overexpression of chemokine receptor 4 (CXCR4) in HNSCC primary tumors associates with higher risk of developing
Externí odkaz:
https://doaj.org/article/e50be74c1cc148efa52967136404a5f2
Autor:
Naroa Serna, Hèctor López-Laguna, Patricia Aceituno, Mauricio Rojas-Peña, Eloi Parladé, Eric Voltà-Durán, Carlos Martínez-Torró, Julieta M. Sánchez, Angela Di Somma, Jose Vicente Carratalá, Andrea L. Livieri, Neus Ferrer-Miralles, Esther Vázquez, Ugutz Unzueta, Nerea Roher, Antonio Villaverde
Publikováno v:
Pharmaceutics, Vol 15, Iss 11, p 2632 (2023)
Both nanostructure and multivalency enhance the biological activities of antimicrobial peptides (AMPs), whose mechanism of action is cooperative. In addition, the efficacy of a particular AMP should benefit from a steady concentration at the local pl
Externí odkaz:
https://doaj.org/article/6614a4d6d5cf47b99c1baa1e50c3f41b
CXCR4-targeted nanotoxins induce GSDME-dependent pyroptosis in head and neck squamous cell carcinoma
Autor:
Elisa Rioja-Blanco, Irene Arroyo-Solera, Patricia Álamo, Isolda Casanova, Alberto Gallardo, Ugutz Unzueta, Naroa Serna, Laura Sánchez-García, Miquel Quer, Antonio Villaverde, Esther Vázquez, Xavier León, Lorena Alba-Castellón, Ramon Mangues
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-17 (2022)
Abstract Background Therapy resistance, which leads to the development of loco-regional relapses and distant metastases after treatment, constitutes one of the major problems that head and neck squamous cell carcinoma (HNSCC) patients currently face.
Externí odkaz:
https://doaj.org/article/97f385e1c3e5483b857dd0c10e41d6d9
Autor:
Aïda Falgàs, Annabel Garcia-León, Yáiza Núñez, Naroa Serna, Laura Sánchez-Garcia, Ugutz Unzueta, Eric Voltà-Durán, Marc Aragó, Patricia Álamo, Lorena Alba-Castellón, Jorge Sierra, Alberto Gallardo, Antonio Villaverde, Esther Vázquez, Ramon Mangues, Isolda Casanova
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 150, Iss , Pp 112940- (2022)
High rates of relapsed and refractory diffuse large B-cell lymphoma (DLBCL) patients and life-threatening side effects associated with immunochemotherapy make an urgent need to develop new therapies for DLBCL patients. Immunotoxins seem very potent a
Externí odkaz:
https://doaj.org/article/48b64a5a2e364d00bfca4db18c016d49
Autor:
Victor Pallarès, Ugutz Unzueta, Aïda Falgàs, Laura Sánchez-García, Naroa Serna, Alberto Gallardo, Gordon A. Morris, Lorena Alba-Castellón, Patricia Álamo, Jorge Sierra, Antonio Villaverde, Esther Vázquez, Isolda Casanova, Ramon Mangues
Publikováno v:
Journal of Hematology & Oncology, Vol 13, Iss 1, Pp 1-19 (2020)
Abstract Background Current acute myeloid leukemia (AML) therapy fails to eliminate quiescent leukemic blasts in the bone marrow, leading to about 50% of patient relapse by increasing AML burden in the bone marrow, blood, and extramedullar sites. We
Externí odkaz:
https://doaj.org/article/87ebec6b3f454f2189fdb0bc4e413690
Autor:
Yáiza Núñez, Annabel Garcia-León, Aïda Falgàs, Naroa Serna, Laura Sánchez-García, Ana Garrido, Jorge Sierra, Alberto Gallardo, Ugutz Unzueta, Esther Vázquez, Antonio Villaverde, Ramon Mangues, Isolda Casanova
Publikováno v:
Pharmaceutics, Vol 15, Iss 3, p 727 (2023)
Despite advances in the development of targeted therapies for acute myeloid leukemia (AML), most patients relapse. For that reason, it is still necessary to develop novel therapies that improve treatment effectiveness and overcome drug resistance. We
Externí odkaz:
https://doaj.org/article/64a89ba3101d4368935e446254b12093
Autor:
Eric Voltà-Durán, Julieta M. Sánchez, Eloi Parladé, Naroa Serna, Esther Vazquez, Ugutz Unzueta, Antonio Villaverde
Publikováno v:
Pharmaceutics, Vol 14, Iss 12, p 2644 (2022)
Protein-based materials intended as nanostructured drugs or drug carriers are progressively gaining interest in nanomedicine, since their structure, assembly and cellular interactivity can be tailored by recruiting functional domains. The main bottle
Externí odkaz:
https://doaj.org/article/68e435eea1d840e48f8b7208ac9f765e
Autor:
Eloi Parladé, Eric Voltà-Durán, Olivia Cano-Garrido, Julieta M. Sánchez, Ugutz Unzueta, Hèctor López-Laguna, Naroa Serna, Montserrat Cano, Manuel Rodríguez-Mariscal, Esther Vazquez, Antonio Villaverde
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 9, p 4958 (2022)
Under the need for new functional and biocompatible materials for biomedical applications, protein engineering allows the design of assemblable polypeptides, which, as convenient building blocks of supramolecular complexes, can be produced in recombi
Externí odkaz:
https://doaj.org/article/cd635b35bb45488891f557faff1046a3