Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Narmada Fernando"'
Autor:
Dakshika Gangani, Wathsala Dissanayake, Rajiva de Silva, Kaushalya Anuradha, Lilani Karunanayake, Narmada Fernando, Senaka Rajapakse, Sunil Premawansa, Shiroma Handunnetti
Publikováno v:
BMC Immunology, Vol 24, Iss 1, Pp 1-11 (2023)
Abstract Background Leptospirosis is a zoonotic disease caused by Leptospira species. Variations in lipopolysaccharide (LPS) structure in Leptospira are known to be associated with the serovar diversity and antigenicity. Development of immunodiagnost
Externí odkaz:
https://doaj.org/article/aa179668147b42e2a02cdec405f4628b
Autor:
Pierre Celestin Munezero, Shiroma Handunnetti, Narmada Fernando, Loshini Ranaweera, Swarna Damayanthi Hapuarachchi, Boniface Makori Nyamweya, Joseph Ndacyayisenga
Publikováno v:
Scientific African, Vol 21, Iss , Pp e01861- (2023)
Infection of endothelial cells (ECs) and their dysfunction has been implicated in the immunopathogenesis leading to severity in dengue virus (DENV) disease and rationalize the therapeutic targeting of the endothelium. Munronia pinnata is a rare medic
Externí odkaz:
https://doaj.org/article/d3d5d83a7e4141fbaf9202f5c9ff84a5
Autor:
Boniface Nyamweya BSc, MSc, Dilani Rukshala BSc, MSc, Narmada Fernando PhD, Rajiva de Silva MBBS, MD, Sunil Premawansa PhD, Shiroma Handunnetti PhD
Publikováno v:
Journal of Evidence-Based Integrative Medicine, Vol 28 (2023)
There has been accumulating interest in the application of medicinal plants as alternative medicine to treat various diseases and/or to develop modern medicines. Vitex negundo is one of such medicinal plants that has been of interest to many research
Externí odkaz:
https://doaj.org/article/eb2d7c31ff424d76bf908d19c8eebbe5
Ion Transport Modulators Differentially Modulate Inflammatory Responses in THP-1-Derived Macrophages
Autor:
Steven C. Mitini-Nkhoma, Narmada Fernando, G. K. D. Ishaka, Shiroma M. Handunnetti, Sisira L. Pathirana
Publikováno v:
Journal of Immunology Research, Vol 2021 (2021)
Ion transport modulators are most commonly used to treat various noncommunicable diseases including diabetes and hypertension. They are also known to bind to receptors on various immune cells, but the immunomodulatory properties of most ion transport
Externí odkaz:
https://doaj.org/article/9d9d715dbe434b72b282d4da2bdddb72
Autor:
Senaka Rajapakse, Praveen N Weeratunga, Krishan Balaji, Kyra Charmaine Ramchandani, Udani Savbhagya de Silva, Shenali Avishka Ranasinghe, Dinesh Gunarathne, Pasindu P B Wijerathne, Narmada Fernando, Shiroma M Handunnetti, Sumadhya Deepika Fernando
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 5, p e0008309 (2020)
Leptospirosis is endemic in Sri Lanka. There is a need for updated seroprevalence studies in endemic areas, to improve the understanding of disease dynamics, risk factors, control methods, and for clinical diagnosis. The cut-off titres for the micros
Externí odkaz:
https://doaj.org/article/9d1386f46b7f4e358e8e8f3d51908a8f
Autor:
Steven C. Mitini-Nkhoma, Narmada Fernando, G. K. D. Ishaka, Shiroma M. Handunnetti, Sisira L. Pathirana
Publikováno v:
Tuberculosis Research and Treatment, Vol 2020 (2020)
There is an urgent need for better and safer therapeutic interventions for tuberculosis (TB). We assessed the effects of FDA-approved ion transport modulators, namely, ambroxol HCl, amiloride HCl, diazoxide, digoxin, furosemide, hydrochlorothiazide (
Externí odkaz:
https://doaj.org/article/d68941a5a616416b9172601876e163fb
Autor:
Senaka Rajapakse, Praveen Weeratunga, Roshan Niloofa, Narmada Fernando, Nipun Lakshitha de Silva, Chaturaka Rodrigo, Sachith Maduranga, Nuwanthi Nandasiri, Sunil Premawansa, Lilani Karunanayake, H Janaka de Silva, Shiroma Handunnetti
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 6, p e0004513 (2016)
Leptospirosis is a zoonotic infection with significant morbidity and mortality. The clinical presentation of leptospirosis is known to mimic the clinical profile of other prevalent tropical fevers. Laboratory confirmation of leptospirosis is based on
Externí odkaz:
https://doaj.org/article/dc3f58dfbefd49c8b8f863390d456d63
Autor:
Narmada Fernando, Shalini Wickremesinghe, Roshan Niloofa, Chaturaka Rodrigo, Lilani Karunanayake, H Janaka de Silva, A R Wickremesinghe, Sunil Premawansa, Senaka Rajapakse, Shiroma M Handunnetti
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0156085 (2016)
Pathogenesis of disease severity in leptospirosis is not clearly understood whether it is due to direct damage by pathogen or by adverse immune responses. Knowledge on biomarkers of oxidative stress which could be used in identifying patients with se
Externí odkaz:
https://doaj.org/article/7a093782234a4982bfcca316d8e7902c
Autor:
Roshan Niloofa, Narmada Fernando, Nipun Lakshitha de Silva, Lilani Karunanayake, Hasith Wickramasinghe, Nandana Dikmadugoda, Gayani Premawansa, Rajitha Wickramasinghe, H Janaka de Silva, Sunil Premawansa, Senaka Rajapakse, Shiroma Handunnetti
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129236 (2015)
BackgroundLeptospirosis is diagnosed on clinical grounds, and confirmed by microscopic agglutination test (MAT). IgM-ELISA (Serion-Virion) and immunochromatography test (Leptocheck-WB) are two immunodiagnostic assays for leptospirosis. Their sensitiv
Externí odkaz:
https://doaj.org/article/e11faf98a8c6429ca28dccd894b36d51
Autor:
SChrishan Jude Jayamaha, AK.D Varuni Yashodha Ratnayake, Narmada Fernando, Thusitha Gajanayake, ShiromaMangalika Handunnetti
Publikováno v:
The Indian journal of medical research.
BK virus (BKV) is a polyomavirus and cause of a common infection after renal transplantation which could be preceded to BKV-associated nephropathy. It has four main subtypes (I-IV). BKV subtypes II and III are rare, whereas subtype I shows a ubiquito