Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Nariman Naber"'
Publikováno v:
Metabolism Open, Vol 9, Iss , Pp 100068- (2021)
Background: The super-relaxed state of myosin (SRX) plays a fundamental role in maintaining the low resting metabolic rate of skeletal muscle. Our previous work on this state has been in animal models. Piperine is a small molecule that has been shown
Externí odkaz:
https://doaj.org/article/92fd8ac1ff7449c0849df5557a9649fb
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0160100 (2016)
In the super-relaxed state of myosin, ATPase activity is strongly inhibited by binding of the myosin heads to the core of the thick filament in a structure known as the interacting-heads motif. In the disordered relaxed state myosin heads are not bou
Externí odkaz:
https://doaj.org/article/e838070331224fc9a216b9b490681edd
Publikováno v:
eLife, Vol 3 (2014)
Hsp90 is a conserved chaperone that facilitates protein homeostasis. Our crystal structure of the mitochondrial Hsp90, TRAP1, revealed an extension of the N-terminal β-strand previously shown to cross between protomers in the closed state. In this s
Externí odkaz:
https://doaj.org/article/bc528b39f216455e85ca326e00eb0884
Autor:
Leonardo Nogara, Kenny Haak, Ryan Meech, Thu Ly, Daniel Elnatan, Alla S. Kostyukova, Nariman Naber, Roger Cooke, Dmitri Tolkatchev
Publikováno v:
Archives of Biochemistry and Biophysics. 659:75-84
Piperine, an alkaloid from black pepper, was found to inhibit the super-relaxed state (SRX) of myosin in fast-twitch skeletal muscle fibers. In this work we report that the piperine molecule binds heavy meromyosin (HMM), whereas it does not interact
Publikováno v:
Metabolism Open, Vol 9, Iss, Pp 100068-(2021)
Metabolism Open
Metabolism Open
Background The super-relaxed state of myosin (SRX) plays a fundamental role in maintaining the low resting metabolic rate of skeletal muscle. Our previous work on this state has been in animal models. Piperine is a small molecule that has been shown
Publikováno v:
Biophysical Journal. 118:120a
Publikováno v:
Biophysical Journal. 114:644a-645a
Autor:
Adam G. Larson, Edward Pate, Hiten D. Madhani, Jennifer F. Garcia, Geeta J. Narlikar, Shenping Wu, Diana B. Marina, Daniele Canzio, Nariman Naber, Roger Cooke, Maofu Liao, Yifan Cheng, Peter Schuck
Publikováno v:
Nature. 496:377-381
The Schizosaccharomyces pombe HP1 protein, Swi6, is shown to exist in an auto-inhibited state when unbound to chromatin, switching to a spreading-competent state upon binding to the HK9 methyl mark; disrupting this switch affects heterochromatin asse
Publikováno v:
Journal of Muscle Research and Cell Motility. 34:35-42
The conformational changes in myosin associated with ADP release and their influence on actin sliding velocity are not understood. Following actin binding, the myosin active site is in equilibrium between a closed and open ADP bound state, with the o
Destabilizing the Super Relaxed State of Skeletal Muscle Myosin to Treat Obesity and Type 2 Diabetes
Publikováno v:
Biophysical Journal. 110(3)
In resting skeletal muscle, myosin is found in 2 states, the super-relaxed state (SRX) and the disordered relaxed state (DRX). In the SRX the ATPase activity is strongly inhibited by binding of the myosin heads to the core of the thick filament; in t