Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Nari Talaty"'
Autor:
Junhai Yang, Lauren Rendino, Steven Cassar, Wayne Buck, James Sawicki, Nari Talaty, David Wagner
Publikováno v:
Pharmaceuticals, Vol 15, Iss 10, p 1230 (2022)
The utility of zebrafish is becoming more frequent due to lower costs and high similarities to humans. Zebrafish larvae are attractive subjects for drug screening and drug metabolism research. However, obtaining good quality zebrafish larvae sections
Externí odkaz:
https://doaj.org/article/eb790bf464644f698dc2fe9f1a8bb21f
Autor:
Nathaniel L. Elsen, Sujatha M. Gopalakrishnan, David Chang-Yen, Andrew J. Radosevich, James W. Sawicki, Jon D. Williams, Fan Pu, Nari Talaty
Publikováno v:
Analytical Chemistry. 93:6792-6800
Mass spectrometry (MS) can provide high sensitivity and specificity for biochemical assays without the requirement of labels, eliminating the risk of assay interference. However, its use had been limited to lower-throughput assays due to the need for
Autor:
Sha Jin, Julie J Purkal, Yu Xiao, Larry R. Solomon, Dan Cojocari, Relja Popovic, Nari Talaty, Erwin R. Boghaert, Darren C. Phillips, Joel D. Leverson
Publikováno v:
Clinical Cancer Research. 26:3371-3383
Purpose: Patients with acute myeloid leukemia (AML) frequently do not respond to conventional therapies. Leukemic cell survival and treatment resistance have been attributed to the overexpression of B-cell lymphoma 2 (BCL-2) and aberrant DNA hypermet
Autor:
Jeffery Y. Pan, James W. Sawicki, Nathaniel L. Elsen, Nari Talaty, Jon D. Williams, Andrew J. Radosevich, Fan Pu, David Chang-Yen
Infrared Matrix-Assisted Laser Desorption Electrospray Ionization (IR-MALDESI) mass spectrometry is an ambient-direct sampling method being developed for high-throughput, label-free, biochemical screening of large-scale compound libraries. Here, we r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfefd4def7d9733737103c54b6fce142
https://doi.org/10.1101/2021.10.25.465730
https://doi.org/10.1101/2021.10.25.465730
Publikováno v:
Reaction Chemistry & Engineering. 4:1589-1594
A detailed overview of a newly developed method for the analysis and processing of chemical library screens is reported. Integration of a DESI 2D source in a pharmaceutical drug discovery setting is accomplished by utilizing this platform on multiple
Publikováno v:
Reaction Chemistry & Engineering. 3:206-209
Electrospray (ES) and paper spray (PS) mass spectrometry were used to create confined liquid volumes in which accelerated air and water sensitive, heterogeneous, copper catalysed C–O and C–N coupling reactions occur. Significant reaction accelera
Autor:
Robert W. Johnson, Nari Talaty
Publikováno v:
ACS medicinal chemistry letters. 10(2)
[Image: see text] Understanding the tissue distribution of therapeutic molecules is often critical for assessing their efficacy and toxicity. Unfortunately, standard methods for monitoring localized drug distribution are resource-intensive and are ty
Autor:
Julie J Purkal, Nari Talaty, Larry R. Solomon, Relja Popovic, Yu Xiao, Erwin R. Boghaert, Dan Cojocari, Sha Jin, Darren C. Phillips, Joel D. Leverson
Publikováno v:
Blood. 132:2644-2644
Acute myeloid leukemia (AML) is a clonal hematologic malignancy characterized by genomic heterogeneity and epigenetic changes, including aberrant DNA hypermethylation. Phase-Ib clinical data in relapsed/refractory AML patients indicate that combining
Publikováno v:
F1000Research
This review covers recent advances in the implementation of enabling chemistry technologies into the drug discovery process. Areas covered include parallel synthesis chemistry, high-throughput experimentation, automated synthesis and purification met
Autor:
Nari Talaty, W. Andy Tao, Yu Xia, R. Graham Cooks, J. Isabella Zhang, Rebecca L. Bell, John H. Callahan, Anthony Costa
Publikováno v:
International Journal of Mass Spectrometry. 301:37-44
Desorption electrospray ionization (DESI) was employed to measure lipids directly from sixteen bacterial samples without extraction or other sample preparation. Differentiation of different bacterial species and some sub-species was achieved using ei