Výsledky vyhledávání - "Nargisse Nejda"

Autor: NARGISSE NEJDA

Initial version of the RadicalZ DMP (M6)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2d962c05286d652dc07d4d24910589c3

A MLH1 polymorphism that increases cancer risk is associated with better outcome in sporadic colorectal cancer

Autor: Vicente Medina Arana, Antonia M. Fernández-Peralta, Daniel Iglesias, Juan J. González-Aguilera, Mariano Moreno Azcoita, Nargisse Nejda

Publikováno v: Cancer Genetics and Cytogenetics. 193:71-77

Germline mutations or the malfunctioning of postreplicative mismatch repair genes (MMR) are responsible of hereditary nonpolyposis colorectal cancer (HNPCC), and are also implied in some sporadic colorectal cancer (CRC) forms without any familial his

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fec0643c2d2d01de2264e03b27665c8
https://doi.org/10.1016/j.cancergencyto.2009.04.011

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Do MSI-L Sporadic Colorectal Tumors Develop Through 'Mild Mutator Pathway'?

Autor: Carlos Cerquella, Soledad Oliart, Lydia Daimiel, Mariano Moreno-Azcoita, Daniel Iglesias, Juan J. González-Aguilera, Nargisse Nejda, Cristina Martinez-Santos, Antonia M. Fernández-Peralta

Publikováno v: American Journal of Clinical Oncology. 29:364-370

Background: The mutator pathway implied in the development of colorectal cancer (CRC) is characterized by microsatellite instability (MSI). MSI tumors can be subdivided according to the level of instability: MSI-H (high), MSI-L (low) or stable MSS. M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5074dfa27ee669b727d3b16509b4860b
https://doi.org/10.1097/01.coc.0000221428.35366.cb

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RIS1, a gene with trinucleotide repeats, is a target in the mutator pathway of colorectal carcinogenesis

Autor: Soledad Oliart, Juan J. González-Aguilera, Antonia M. Fernández-Peralta, Lidia Daimiel, Nargisse Nejda, Mariano Moreno Azcoita, Daniel Iglesias

Publikováno v: Cancer Genetics and Cytogenetics. 167:138-144

Microsatellite instability (MSI) due to mismatch repair system (MMR) alterations characterizes the mutator pathway implied in colorectal cancer development. In the present study, we have analyzed the gene RIS1 (Ras-induced senescence 1) in relation t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8bbd8a26c387afd90424e0bdade9c51
https://doi.org/10.1016/j.cancergencyto.2005.12.002

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Significance of mutations in TGFBR2 and BAX in neoplastic progression and patient outcome in sporadic colorectal tumors with high-frequency microsatellite instability

Autor: Soledad Oliart, Antonia M. Fernández-Peralta, Mariano Moreno Azcoita, Juan J. González-Aguilera, Vicente Medina, Nargisse Nejda

Publikováno v: Cancer Genetics and Cytogenetics. 157:18-24

The mutator pathway implied in the development of colorectal cancer is characterized by microsatellite instability (MSI), which is determined by alterations of mismatch repair (MMR) genes. Defects in MMR genes affect repetitive DNA tracts intersperse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57fc157ce783778293bde64c28c51dac
https://doi.org/10.1016/j.cancergencyto.2004.05.008

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Association of polymorphisms MTHFR C677T and A1298C with risk of colorectal cancer, genetic and epigenetic characteristic of tumors, and response to chemotherapy

Autor: Lydia Daimiel, Antonia M. Fernández-Peralta, Daniel Iglesias, Juan J. González-Aguilera, Vicente Medina Arana, Nargisse Nejda

Publikováno v: International journal of colorectal disease. 25(2)

The enzyme MTHFR plays an important role in folate metabolism, and folate is implicated in carcinogenesis due to its role in DNA methylation, repair, and synthesis. We analyze the relationship of MTHFR C677T and A1298C polymorphisms with biological,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b56f5367de39145b28c2e7608261818
https://pubmed.ncbi.nlm.nih.gov/19669769

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Effect of COX2 -765GC and c.3618AG polymorphisms on the risk and survival of sporadic colorectal cancer

Autor: Antonia M. Fernández-Peralta, Simó Schwartz, Nargisse Nejda, Daniel Iglesias, Juan J. González-Aguilera, Mariano Moreno Azcoita

Publikováno v: Cancer causescontrol : CCC. 20(8)

The COX2 gene (also known as PTGS2) encodes one of the essential cyclooxygenases for the prostanoid synthesis, and its expression is tightly regulated at both transcriptional and posttranscriptional levels. COX2 overexpression has been detected in up

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39cc68a1279c206fbad1686694a1b16b
https://pubmed.ncbi.nlm.nih.gov/19468846

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Genetic alterations and MSI status in primary, synchronous, and metachronous tumors in a family with hereditary nonpolyposis colorectal cancer (HNPCC)

Autor: Fernando González-Hermoso, Ysamar Barrios, Juan J. González-Aguilera, Francisco J. Fernández, Mariano Moreno Azcoita, Vicente Medina, Antonia M. Fernández-Peralta, Nargisse Nejda

Publikováno v: American journal of clinical oncology. 26(4)

In colorectal cancer, different levels of microsatellite instability (MSI) have been described: high-frequency MSI, low-frequency MSI, and stable microsatellites. MSI-H characterizes a unique clinical and pathologic phenotype known as hereditary nonp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::174032ae23639d2740ecfc808992f53d
https://pubmed.ncbi.nlm.nih.gov/12902892

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