Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Nareshkumar F. Jain"'
Publikováno v:
Pharmaceutical Research
The list of ADCs in the clinic continues to grow, bolstered by the success of first two marketed ADCs: ADCETRIS® and Kadcyla®. Currently, there are 40 ADCs in various phases of clinical development. However, only 34 of these have published their st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d96fdb2ec365cb21af932b2e714e53b
https://doi.org/10.1007/s11095-015-1657-7
https://doi.org/10.1007/s11095-015-1657-7
Autor:
Dmitry Borkin, Jagath Reddy Junutula, Jianqing Huang, Nareshkumar F. Jain, Jennifer Lu, Ying-Ping Jiang, Vasu Jammalamadaka, Sean W. Smith, Sylvia J. Degrado, Jianyu Zhu
Publikováno v:
ACS medicinal chemistry letters. 9(1)
Antibody–drug conjugates (ADCs) represent an important class of emerging cancer therapeutics. Recent ADC development efforts highlighted the use of pyrrolobenzodiazepine (PBD) dimer payload for the treatment of several cancers. We identified the is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a0badbfd90b1fa8d1b9a4c6d394b4b8
https://pubmed.ncbi.nlm.nih.gov/29348812
https://pubmed.ncbi.nlm.nih.gov/29348812
Autor:
Sylvia Degrado, Kimberly D. Klarmann, Dimiter S. Dimitrov, Julia Scheiermann, Brad St. Croix, Zhongyu Zhu, Dmitry Borkin, Yang Feng, Steven Seaman, Mi Young Yang, Enrique Zudaire, Holly Morris, Yanping Wang, Nareshkumar F. Jain, Karen Morris, Jinyu Li, Mary Beth Hilton, Sean W. Smith, Jonathan R. Keller, Lino Tessarollo, Saurabh Saha, Christopher S. Szot, Amit Chaudhary, Deborah A. Swing, Xiaoyan M. Zhang, Decrescenzo Gary A, Dean Welsch
Publikováno v:
Cancer cell. 31(4)
Targeting the tumor vasculature with antibody-drug conjugates (ADCs) is a promising anti-cancer strategy that in order to be realized must overcome several obstacles, including identification of suitable targets and optimal warheads. Here, we demonst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::257e54fd4eb07b60c386f5f0fcd573a3
https://pubmed.ncbi.nlm.nih.gov/28399405
https://pubmed.ncbi.nlm.nih.gov/28399405
Autor:
Dominique Depré, Wim Albert Alex Aelterman, Zhihua Sui, Xun Li, Dominic Ormerod, Andras Horvath, Nareshkumar F. Jain, Ronald K. Russell
Publikováno v:
Organic Process Research & Development. 13:102-105
A novel and economical process was developed for recycling the undesired enantiomer, (S)-2,8-dimethoxy-5-{4-[2-(1-piperidinyl)ethoxy]phenyl}-11,12-dihydro-5H-6,13-dioxabenzo[3,4]cyclohepta[1,2-a]naphthalene (1b) obtained from chiral chromatographic s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8f8e82beeee259d1ad9404fc112ffaf
https://doi.org/10.1021/op800237y
https://doi.org/10.1021/op800237y
Autor:
Nareshkumar F. Jain, Xin Chen, Pamela Tannenbaum, Zhihua Sui, Fu-An Kang, Scott G. Lundeen, George F. Allan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:3687-3690
Replacement of the 7-CH2 group of natural steroid with an oxygen atom led to identification of unnatural 7-oxa-steroids as potent and selective progesterone receptor antagonists. The unnatural 7-oxa-steroids exhibited a different structure–activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d81228f8b511ad9201d867e2a05bbb6
https://doi.org/10.1016/j.bmcl.2008.05.070
https://doi.org/10.1016/j.bmcl.2008.05.070
Autor:
Shawn Branum, Ramesh M. Kanojia, Xun Li, Robert Ma, Ronald K. Russell, Nareshkumar F. Jain, Scott Youells, Sandra Beish, Richard E. Adams, Michael Reuman, Zhihua Sui, Jerry R. Roberts
Publikováno v:
Organic Process Research & Development. 11:414-421
Unsymmetrical benzopyranobenzopyran compounds are novel selective estrogen receptor modulators (SERMs). A reproducible and nonchromatographic process was developed to prepare multihundred gram quan...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f4cb618e3ea2c58fe9d5bdadb95eb45
https://doi.org/10.1021/op700020f
https://doi.org/10.1021/op700020f
Autor:
George F. Allan, Peifang Zhu, Joseph W. Gunnet, Olivia Linton, Nareshkumar F. Jain, Keith T. Demarest, Scott G. Lundeen, Jihua Guan, Pamela Tannenbaum, Xin Chen, Fu-An Kang, Jun Xu, Zhihua Sui
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:907-910
A novel series of oxa-steroids 6 derived from (8S, 13S, 14R)-7-oxa-estra-4,9-diene-3,17-dione 1 have been synthesized and identified as potent and selective progesterone receptor antagonists. These novel oxa-steroids showed similar potency to mifepri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1159f96481f08897c9d24f53de4a2ce7
https://doi.org/10.1016/j.bmcl.2006.11.062
https://doi.org/10.1016/j.bmcl.2006.11.062
Publikováno v:
Tetrahedron Letters. 48:193-197
The first enantioselective synthesis of (8 S ,13 S ,14 R )-7-oxa-estra-4,9-diene-3,17-dione with the trans -C/D ring junction is described. Key features of the synthesis include Ag 2 O-mediated C–O bond formation, thermodynamically controlled axial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::adf8f93ab34bfea143678e5552ef0e4d
https://doi.org/10.1016/j.tetlet.2006.11.042
https://doi.org/10.1016/j.tetlet.2006.11.042
Publikováno v:
Tetrahedron Letters. 47:9021-9024
The first synthesis of a novel oxa-steroid, rac-(8R,13S,14S)-7-oxa-estra-4,9-diene-3,17-dione has been achieved via stereoselective catalytic hydrogenation of the tetra-substituted indene intermediate, whose structure was confirmed by X-ray crystallo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25f7454e5d9d0ea73403eb8c20538e8d
https://doi.org/10.1016/j.tetlet.2006.10.098
https://doi.org/10.1016/j.tetlet.2006.10.098
Autor:
Zhihua Sui, Ronald K. Russell, Ningyi Chen, Michael Reuman, Nareshkumar F. Jain, Jiayi Xu, Xun Li
Publikováno v:
Tetrahedron Letters. 47:5909-5913
Various substituents were introduced onto the methyl group in 4-methyl coumarins through lithiation, followed by reactions with a wide range of electrophiles. The presence of an alkoxy group on 6′-phenyl ring was found to be pivotal for the success
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdce82ef1aca86157743675b7d05ba68
https://doi.org/10.1016/j.tetlet.2006.06.047
https://doi.org/10.1016/j.tetlet.2006.06.047