Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Naresh Kandakatla"'
Autor:
Rajasekhar Chekkara, Naresh Kandakatla, Venkata Reddy Gorla, Sobha Rani Tenkayala, E Susithra
Publikováno v:
Journal of Saudi Chemical Society, Vol 21, Iss S1, Pp S311-S321 (2017)
Molecular modeling studies were carried out on a series of benzimidazole and imidazo[1,2-a]pyridines as Plk1 inhibitors. Based on the pharmacophore model, we obtained a five-featured hypothesis AADRR, with two hydrogen bond acceptors, one hydrogen bo
Externí odkaz:
https://doaj.org/article/c2065fe1d55f4a47939a11f8f5d9c92d
Publikováno v:
Bangladesh Journal of Pharmacology, Vol 8, Iss 3, Pp 328-335 (2013)
Histone deacetylases2, Class 1 HDAC family are emerged as an important therapeutic target for the treatment of various cancers. HDAC2 inhibitors are potent anti-cancer agents. Two inhibitors of HDAC2 are Hydroxamic acid and Valporic acid which are po
Externí odkaz:
https://doaj.org/article/2b3726f5d2da449e856acad529291f93
Autor:
Venkatesan Srinivasadesikan, Srinivasa Rao Bolla, Murad Alsawalha, Vishnu Priya Veeraraghavan, Naresh Kandakatla, Krishna Mohan Surapaneni
Publikováno v:
Bioinformation
Histone deacetylase (HDAC2) belongs to the hydrolase family and a promising target for cancers. We reported 96 hydroxamic compounds optimized using hydrogen-donors, hydrophobic and electron withdrawing groups followed by molecular docking studies. Th
Publikováno v:
Interdisciplinary Sciences: Computational Life Sciences. 8:303-311
Glycogen synthase kinase-3β (GSK-3β) is a kinase family enzyme and an emerged target for the treatment of various diseases. A total of 23 structurally diverse flavonoid inhibitors were used to generate pharmacophore models using HypoGen algorithm.
Publikováno v:
Oriental Journal of Chemistry. 30:1083-1098
Tubulin is attractive target for anticancer drug design and their inhibitors are useful in treatment of various cancers. Pharmacophore and Atom based QSAR studies were carried out for series of Chalcone derivatives. Pharmacophore model was developed
Publikováno v:
Frontiers in Biology. 9:410-421
Niemann-Pick disease type C1 (NPC1), caused by mutations of NPC1 gene, is an inherited lysosomal lipid storage disorder. Loss of functional NPC1 causes the accumulation of free cholesterol (FC) in endocytic organelles that comprised the characteristi
Autor:
Geetha Ramakrishnan, Naresh Kandakatla
Publikováno v:
Advances in Bioinformatics, Vol 2014 (2014)
Advances in Bioinformatics
Advances in Bioinformatics
Histone deacetylases 2 (HDAC2), Class I histone deacetylase (HDAC) family, emerged as an important therapeutic target for the treatment of various cancers. A total of 48 inhibitors of two different chemotypes were used to generate pharmacophore model
Publikováno v:
Bangladesh Journal of Pharmacology. 8
Histone deacetylases2, Class 1 HDAC family are emerged as an important therapeutic target for the treatment of various cancers. HDAC2 inhibitors are potent anti-cancer agents. Two inhibitors of HDAC2 are Hydroxamic acid and Valporic acid which are po
Autor:
Rajasekhar Chekkara, Sobha Rani Tenkayala, Venkata Reddy Gorla, Naresh Kandakatla, E Susithra
Publikováno v:
Journal of Saudi Chemical Society. :S311-S321
Molecular modeling studies were carried out on a series of benzimidazole and imidazo[1,2-a]pyridines as Plk1 inhibitors. Based on the pharmacophore model, we obtained a five-featured hypothesis AADRR, with two hydrogen bond acceptors, one hydrogen bo
Publikováno v:
Scopus-Elsevier
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::78173d1accd476077ee0ca672e5caa54
http://www.scopus.com/inward/record.url?eid=2-s2.0-84897138379&partnerID=MN8TOARS
http://www.scopus.com/inward/record.url?eid=2-s2.0-84897138379&partnerID=MN8TOARS