Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Naresh Chadha"'
Autor:
Carl L. Manthey, Nand Baindur, Ioanna Petrounia, Celine Schalk-Hihi, Naresh Chadha, Christian Andrew Baumann, Heidi Ott, Benjamin M. Brandt, Raymond J. Patch, Mark R. Player, Davoud Asgari, Barry A. Springer, Theodore E. Carver
Publikováno v:
Journal of Medicinal Chemistry. 48:1717-1720
2-Hydroxy-4,6-diamino-[1,3,5]triazines are described which are a novel class of potent inhibitors of the VEGF-R2 (flk-1/KDR) tyrosine kinase. 4-(Benzothiazol-6-ylamino)-6-(benzyl-isopropyl-amino)-[1,3,5]triazin-2-ol (14d) exhibited low nanomolar pote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b94f50d28b146febb8ae2b013be4b1ff
https://doi.org/10.1021/jm049372z
https://doi.org/10.1021/jm049372z
Publikováno v:
Journal of Combinatorial Chemistry. 6:414-419
Primary amines were immobilized on (4-formyl-3,5-dimethoxyphenoxy)methylpolystyrene resin via reductive amination. Attachment of two different 4-chloro-2-methylthiopyrimidines, followed by sulfide oxidation, led to their corresponding sulfone interme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cf98dd12d2653a43d9438ae3db2bf58
https://doi.org/10.1021/cc049956m
https://doi.org/10.1021/cc049956m
Publikováno v:
Journal of Combinatorial Chemistry. 5:653-659
An efficient solution-phase parallel synthesis of a library of 3,5,7-trisubstituted [1,2,3]triazolo[4,5-d]pyrimidines is described. Monosubstituted amidines may be converted to 2-substituted 5-amino-4,6-dihydroxypyrimidines in four steps. Treatment w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7bdecf1440329252017c2f34f4ae2a8
https://doi.org/10.1021/cc020110x
https://doi.org/10.1021/cc020110x
Autor:
Mark R. Player, Richard S. Pottorf, Vita Ozola, Naresh Chadha, Hadi Ghane, Martins Katkevics, Edgars Suna, Tor Regberg
Publikováno v:
Tetrahedron Letters. 44:175-178
A facile route to benzoxazoles has been developed using microwave-assisted dielectric heating. The ease of synthesis and workup allowed the parallel synthesis of a 48-membered library of benzoxazoles quickly and efficiently.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76aa4b01c27f2c1bba46263959d2c4df
https://doi.org/10.1016/s0040-4039(02)02495-4
https://doi.org/10.1016/s0040-4039(02)02495-4
Autor:
Andrew D. Batcho, Charles M. Cook, L. F. Courtney, Milan R. Uskokovic, P. C. Tang, Naresh Chadha, Peter M. Wovkulich
Publikováno v:
ChemInform. 22
An asymmetric synthesis of tetrahydrolipstatin (4) is described. Application of our previously described in situ cyclopentadiene alkylation-asymmetric hydroboration protocol provided the key chiral alcohol 9. In the course of this work, the presence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b6cdce93dbe941ff4d5ac672e66c6c9
https://doi.org/10.1002/chin.199152163
https://doi.org/10.1002/chin.199152163
Autor:
P. C. Tang, Naresh Chadha, Andrew D. Batcho, L. F. Courtney, Charles M. Cook, Milan R. Uskokovic, Peter M. Wovkulich
Publikováno v:
The Journal of Organic Chemistry. 56:4714-4718
An asymmetric synthesis of tetrahydrolipstatin (4) is described. Application of our previously described in situ cyclopentadiene alkylation-asymmetric hydroboration protocol provided the key chiral alcohol 9. In the course of this work, the presence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba23aa3e57b98f794354dc1ba7105406
https://doi.org/10.1021/jo00015a027
https://doi.org/10.1021/jo00015a027
Autor:
Nand Baindur, Margery A. Chaikin, Davoud Asgari, Wing S. Cheung, Ioanna Petrounia, Robert R. Donatelli, Taxiarchis Georgiadis, Naresh Chadha, Raymond J. Patch, Mark R. Player, Benjamin M. Brandt
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(22)
A series of 2′-aminoanilides have been identified which exhibit potent and selective inhibitory activity against the cFMS tyrosine kinase. Initial SAR studies within this series are described which examine aroyl and amino group substitutions, as we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b254ce72dd5d6d9327f28dd38d984ba2
https://pubmed.ncbi.nlm.nih.gov/17904845
https://pubmed.ncbi.nlm.nih.gov/17904845
Publikováno v:
ChemInform. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::117bcf8c365b7d8fa40be11068ba55f6
https://doi.org/10.1002/chin.200403157
https://doi.org/10.1002/chin.200403157
Publikováno v:
Journal of the American Chemical Society. 95:532-540
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e37ab5bd22c72420db689f1e3e77da36
https://doi.org/10.1021/ja00783a037
https://doi.org/10.1021/ja00783a037
Autor:
Naresh Chadha, John Joseph Partridge, John F. Blount, Enrico G. Baggiolini, Shian Jan Shiuey, Milan R. Uskokovic
Publikováno v:
Journal of the American Chemical Society. 103:1253-1255
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7caa915c5e71654bbeb42ce6c9fdd8d
https://doi.org/10.1021/ja00395a061
https://doi.org/10.1021/ja00395a061