Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Narese/7"'
Autor:
Richard Heery, Martin H Schaefer
Publikováno v:
Nucleic Acids Research
While large-scale studies applying various statistical approaches have identified hundreds of mutated driver genes across various cancer types, the contribution of epigenetic changes to cancer remains more enigmatic. This is partly due to the fact th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e01b77b0c5cc009859cd4667689b3f12
https://doi.org/10.1093/nar/gkab1167
https://doi.org/10.1093/nar/gkab1167
Autor:
Lang Zeng, Zhiyuan Yuan, Min-Ping Qian, Minglei Shi, Zhen-Yi Wang, Yang Chen, Michael Q. Zhang, Qiming Zhou, Yanjie Zhong, Zhaofeng Ye
Publikováno v:
Nucleic Acids Research
Clustering cells and depicting the lineage relationship among cell subpopulations are fundamental tasks in single-cell omics studies. However, existing analytical methods face challenges in stratifying cells, tracking cellular trajectories, and ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bd9203d3313fca02752d04f54285b75
http://europepmc.org/articles/PMC8754642
http://europepmc.org/articles/PMC8754642
Publikováno v:
Nucleic Acids Research
Synonymous single nucleotide variants (sSNVs) are common in the human genome but are often overlooked. However, sSNVs can have significant biological impact and may lead to disease. Existing computational methods for evaluating the effect of sSNVs su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fa88bebab0309294a7e5d757f707a84
https://doi.org/10.1093/nar/gkab1159
https://doi.org/10.1093/nar/gkab1159
Publikováno v:
Nucleic Acids Research
Large indels greatly impact the observable phenotypes in different organisms including plants and human. Hence, extracting large indels with high precision and sensitivity is important. Here, we developed IndelEnsembler to detect large indels in 1047
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3821f0a18969bcce944f81308b71e1a5
https://doi.org/10.1093/nar/gkab904
https://doi.org/10.1093/nar/gkab904
Publikováno v:
Nucleic Acids Research
Long-range regulation by distal enhancers plays critical roles in cell-type specific transcriptional programs. Computational predictions of genome-wide enhancer–promoter interactions are still challenging due to limited accuracy and the lack of kno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1d79e715cf475555a72fd6b618e6e9d
http://europepmc.org/articles/PMC8501976
http://europepmc.org/articles/PMC8501976
Autor:
Jiazhi Hu, Mengzhu Liu, Chen Ai, Changchang Xin, Jiaxin Li, Weiwei Zhang, Fei-Long Meng, Yafang Shang, Jianhang Yin
Publikováno v:
Nucleic Acids Research
CRISPR–Cas9 generates double-stranded DNA breaks (DSBs) to activate cellular DNA repair pathways for genome editing. The repair of DSBs leads to small insertions or deletions (indels) and other complex byproducts, including large deletions and chro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90d605afa77a8f17ec6c9f7ae5889508
https://doi.org/10.1093/nar/gkab686
https://doi.org/10.1093/nar/gkab686
Autor:
Graham McVicker, Yi Fu, Sélène T. Tyndale, Arya R. Massarat, Galina Erikson, Arko Sen, Jeff Jaureguy
Publikováno v:
Nucleic Acids Research
Genetic variants and de novo mutations in regulatory regions of the genome are typically discovered by whole-genome sequencing (WGS), however WGS is expensive and most WGS reads come from non-regulatory regions. The Assay for Transposase-Accessible C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4de649ca162f28f8eb8a8154450b036
https://doi.org/10.1093/nar/gkab621
https://doi.org/10.1093/nar/gkab621
Publikováno v:
Nucleic Acids Research
Chromatin is a tightly packaged structure of DNA and protein within the nucleus of a cell. The arrangement of different protein complexes along the DNA modulates and is modulated by gene expression. Measuring the binding locations and occupancy level
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d5d19380d7ca75d3a09df97d5744766
https://doi.org/10.1093/nar/gkab553
https://doi.org/10.1093/nar/gkab553
Autor:
Rebeca Queiroz Figueiredo, Tamara Raschka, Martin Hofmann-Apitius, Sarah Mubeen, Alpha Tom Kodamullil, Daniel Domingo-Fernández
Publikováno v:
Nucleic Acids Research
In this work, we attempt to address a key question in the joint analysis of transcriptomic data: can we correlate the patterns we observe in transcriptomic datasets to known molecular interactions and pathway knowledge to broaden our understanding of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b1836a3970e80278ec04512d5c90da6
https://doi.org/10.1093/nar/gkab556
https://doi.org/10.1093/nar/gkab556
Publikováno v:
Nucleic Acids Research
There is a pressing need today to mechanistically interpret sets of genomic variants associated with diseases. Here we present a tool called ‘VarSAn’ that uses a network analysis algorithm to identify pathways relevant to a given set of variants.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17776b8856ad9106bd33f8d1182bdaed
http://europepmc.org/articles/PMC8421213
http://europepmc.org/articles/PMC8421213