Genomic landscape of single-stranded DNA gapped intermediates inEscherichia coli

Autor: Phuong Pham, Yijun Shao, Michael M Cox, Myron F Goodman

Publikováno v: Nucleic Acids Research

Single-stranded (ss) gapped regions in bacterial genomes (gDNA) are formed on W- and C-strands during replication, repair, and recombination. Using non-denaturing bisulfite treatment to convert C to U on ssDNA, combined with deep sequencing, we have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5e25f857df1a7e0f50daa536d3d22ec
https://doi.org/10.1093/nar/gkab1269

DrugCentral 2021 supports drug discovery and repositioning

Autor: Ramona Curpan, Sorin Avram, Alina Bora, Giovanni Bocci, Cristian Bologa, Thomas B Wilson, Jeffrey Knockel, Jayme Holmes, Oleg Ursu, Jeremy J. Yang, Suman Sirimulla, Tudor I. Oprea, Liliana Halip, Dac-Trung Nguyen

Publikováno v: Nucleic Acids Research
Avram, S, Bologa, C G, Holmes, J, Bocci, G, Wilson, T B, Nguyen, D T, Curpan, R, Halip, L, Bora, A, Yang, J J, Knockel, J, Sirimulla, S, Ursu, O & Oprea, T I 2021, ' DrugCentral 2021 supports drug discovery and repositioning ', Nucleic Acids Research, vol. 49, no. D1, pp. D1160-D1169 . https://doi.org/10.1093/nar/gkaa997

DrugCentral is a public resource (http://drugcentral.org) that serves the scientific community by providing up-to-date drug information, as described in previous papers. The current release includes 109 newly approved (October 2018 through March 2020

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71e94c21cf7ef8a42154a7f3ca47611a
http://europepmc.org/articles/PMC7779058

HI-NESS: a family of genetically encoded DNA labels based on a bacterial nucleoid-associated protein

Autor: Patrick Voskamp, Daphne E. C. Boer, Monica Varela Alvarez, Martijn S. Luijsterburg, Fatema-Zahra M Rashid, Frédéric Crémazy, Daan J.W. Brocken, Thomas S Shimizu, Joachim Goedhart, Remus T. Dame, Annemarie H. Meijer, Michiel van der Vaart, Eike K. Mahlandt, Anneloes Blok, Bram Henneman

Publikováno v: Nucleic Acids Research, 50(2). OXFORD UNIV PRESS
Nucleic Acids Research, 50(2). Oxford University Press (OUP)
Nucleic Acids Research, 50(2)
Nucleic Acids Research, 50(2):e10. Oxford University Press
Nucleic Acids Research

The interplay between three-dimensional chromosome organisation and genomic processes such as replication and transcription necessitates in vivo studies of chromosome dynamics. Fluorescent organic dyes are often used for chromosome labelling in vivo.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fba901b9bbc62518f82a6e59a9e16dd8
http://hdl.handle.net/1887/3563888

H2A mono-ubiquitination differentiates FACT's functions in nucleosome assembly and disassembly

Autor: Yi-Zhou Wang, Cuifang Liu, Jicheng Zhao, Juan Yu, Anfeng Luo, Xue Xiao, Shuo-Xing Dou, Lu Ma, Peng-Ye Wang, Ming Li, Guohong Li, Jianbin Yan, Ping Chen, Wei Li

Publikováno v: Nucleic Acids Research

The histone chaperone FACT (FAcilitates Chromatin Transcription) plays an essential role in transcription and DNA replication by its dual functions on nucleosome assembly to maintain chromatin integrity and nucleosome disassembly to destabilize nucle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::583bdd683d1eaf6ca258d0b51ed3d5ee
https://pubmed.ncbi.nlm.nih.gov/34951461

Multiplexed single-cell profiling of chromatin states at genomic loci by expansion microscopy

Autor: Hao Yuan Kueh, Phuc H.B. Nguyen, Nicholas A. Pease, Kenneth K.H. Ng, Marcus A. Woodworth, Aaron R. Halpern, Joshua C. Vaughan

Publikováno v: Nucleic Acids Research

Proper regulation of genome architecture and activity is essential for the development and function of multicellular organisms. Histone modifications, acting in combination, specify these activity states at individual genomic loci. However, the metho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcf71e7b89e01e9da6c34f28a27bd54f
https://pubmed.ncbi.nlm.nih.gov/34048564