Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Narese/24"'
Publikováno v:
Nucleic Acids Research
Pseudotime analysis from scRNA-seq data enables to characterize the continuous progression of various biological processes, such as the cell cycle. Cell cycle plays an important role in cell fate decisions and differentiation and is often regarded as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::456b09acb274ce01714e236221132ae9
https://doi.org/10.1093/nar/gkab1236
https://doi.org/10.1093/nar/gkab1236
Autor:
Richard Heery, Martin H Schaefer
Publikováno v:
Nucleic Acids Research
While large-scale studies applying various statistical approaches have identified hundreds of mutated driver genes across various cancer types, the contribution of epigenetic changes to cancer remains more enigmatic. This is partly due to the fact th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e01b77b0c5cc009859cd4667689b3f12
https://doi.org/10.1093/nar/gkab1167
https://doi.org/10.1093/nar/gkab1167
Autor:
Lang Zeng, Zhiyuan Yuan, Min-Ping Qian, Minglei Shi, Zhen-Yi Wang, Yang Chen, Michael Q. Zhang, Qiming Zhou, Yanjie Zhong, Zhaofeng Ye
Publikováno v:
Nucleic Acids Research
Clustering cells and depicting the lineage relationship among cell subpopulations are fundamental tasks in single-cell omics studies. However, existing analytical methods face challenges in stratifying cells, tracking cellular trajectories, and ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bd9203d3313fca02752d04f54285b75
http://europepmc.org/articles/PMC8754642
http://europepmc.org/articles/PMC8754642
Publikováno v:
Nucleic Acids Research
Synonymous single nucleotide variants (sSNVs) are common in the human genome but are often overlooked. However, sSNVs can have significant biological impact and may lead to disease. Existing computational methods for evaluating the effect of sSNVs su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fa88bebab0309294a7e5d757f707a84
https://doi.org/10.1093/nar/gkab1159
https://doi.org/10.1093/nar/gkab1159
Autor:
Sarah Adi Eisdorfer, Morya Ifrach, Stefan Ilic, Dan Vilenchik, Ariel Afek, Barak Akabayov, Adam Soffer, Hallel Schussheim
Publikováno v:
Nucleic Acids Research
DNA–protein interactions play essential roles in all living cells. Understanding of how features embedded in the DNA sequence affect specific interactions with proteins is both challenging and important, since it may contribute to finding the means
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::450a9124e653dc776605a3004b789195
https://doi.org/10.1093/nar/gkab956
https://doi.org/10.1093/nar/gkab956
Publikováno v:
Nucleic Acids Research
Large indels greatly impact the observable phenotypes in different organisms including plants and human. Hence, extracting large indels with high precision and sensitivity is important. Here, we developed IndelEnsembler to detect large indels in 1047
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3821f0a18969bcce944f81308b71e1a5
https://doi.org/10.1093/nar/gkab904
https://doi.org/10.1093/nar/gkab904
Autor:
Douglas J. Hartman, Zengbiao Qi, Hatice U. Osmanbeyoglu, Harinder Singh, Xiaojun Ma, Ashwin Somasundaram
Publikováno v:
Nucleic Acids Research
The identity and functions of specialized cell types are dependent on the complex interplay between signaling and transcriptional networks. Recently single-cell technologies have been developed that enable simultaneous quantitative analysis of cell-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec8f6a27c216105e035176e6241d5197
https://doi.org/10.1093/nar/gkab745
https://doi.org/10.1093/nar/gkab745
Publikováno v:
Nucleic Acids Research
Long-range regulation by distal enhancers plays critical roles in cell-type specific transcriptional programs. Computational predictions of genome-wide enhancer–promoter interactions are still challenging due to limited accuracy and the lack of kno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1d79e715cf475555a72fd6b618e6e9d
http://europepmc.org/articles/PMC8501976
http://europepmc.org/articles/PMC8501976
Autor:
Andrew M. Watkins, Po-Ssu Huang, Hannah K. Wayment-Steele, John J Nicol, Eterna Participants, Roger Wellington-Oguri, Do Soon Kim, Rhiju Das, Christian A Choe, R Andres Parra Sperberg
Publikováno v:
Nucleic Acids Research
bioRxiv
article-version (status) pre
article-version (number) 1
bioRxiv
article-version (status) pre
article-version (number) 1
RNA hydrolysis presents problems in manufacturing, long-term storage, world-wide delivery, and in vivo stability of messenger RNA (mRNA)-based vaccines and therapeutics. A largely unexplored strategy to reduce mRNA hydrolysis is to redesign RNAs to f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df3ccd11ba7fe72a76cf66277a3633e3
http://europepmc.org/articles/PMC8499941
http://europepmc.org/articles/PMC8499941
Autor:
Joanna Sarzynska, Ryszard W. Adamiak, Agnieszka Korpeta, Marta Szachniuk, Mariusz Popenda, Tomasz Zok, Maciej Antczak
Publikováno v:
Nucleic Acids Research
Computational methods to predict RNA 3D structure have more and more practical applications in molecular biology and medicine. Therefore, it is crucial to intensify efforts to improve the accuracy and quality of predicted three-dimensional structures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ac3d8cbca37034aaaf57b76d20f51a2
http://europepmc.org/articles/PMC8464073
http://europepmc.org/articles/PMC8464073