Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Narendra M Dixit"'
Publikováno v:
PLoS Pathogens, Vol 18, Iss 6, p e1010630 (2022)
SARS-CoV-2 infection results in highly heterogeneous outcomes, from cure without symptoms to acute respiratory distress and death. Empirical evidence points to the prominent roles of innate immune and CD8 T-cell responses in determining the outcomes.
Externí odkaz:
https://doaj.org/article/bd6c6d7f648f4065b8ff5c66d090c50b
Autor:
Ananthu James, Narendra M Dixit
Publikováno v:
PLoS Pathogens, Vol 18, Iss 3, p e1010319 (2022)
Transmission bottlenecks introduce selection pressures on HIV-1 that vary with the mode of transmission. Recent studies on small cohorts have suggested that stronger selection pressures lead to fitter transmitted/founder (T/F) strains. Manifestations
Externí odkaz:
https://doaj.org/article/12706792c6ae4a8d9535c59ae4b2f82b
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 12, p e1008461 (2020)
The entry of SARS-CoV-2 into target cells requires the activation of its surface spike protein, S, by host proteases. The host serine protease TMPRSS2 and cysteine proteases Cathepsin B/L can activate S, making two independent entry pathways accessib
Externí odkaz:
https://doaj.org/article/e5860727306041d4bb2452a7dad55582
Autor:
Ananya Saha, Narendra M Dixit
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 11, p e1008434 (2020)
Passive immunization with broadly neutralizing antibodies (bNAbs) of HIV-1 appears a promising strategy for eliciting long-term HIV-1 remission. When administered concomitantly with the cessation of antiretroviral therapy (ART) to patients with estab
Externí odkaz:
https://doaj.org/article/4542bb6ecfe64c76a89344b7e8add5ce
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 8, p e1008064 (2020)
Antiretroviral therapy (ART) for HIV-1 infection is life-long. Stopping therapy typically leads to the reignition of infection and progressive disease. In a major breakthrough, recent studies have shown that early initiation of ART can lead to sustai
Externí odkaz:
https://doaj.org/article/7fd34ff8fc544c6c96f0422f739e6b2d
Publikováno v:
PLoS Pathogens, Vol 15, Iss 4, p e1007701 (2019)
Knowledge of the within-host frequencies of resistance-associated amino acid variants (RAVs) is important to the identification of optimal drug combinations for the treatment of hepatitis C virus (HCV) infection. Multiple RAVs may exist in infected i
Externí odkaz:
https://doaj.org/article/9c61c03d1d1245588d38785bebbc7328
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 7, p e1006335 (2018)
Direct-acting antiviral agents (DAAs) for hepatitis C treatment tend to fare better in individuals who are also likely to respond well to interferon-alpha (IFN), a surprising correlation given that DAAs target specific viral proteins whereas IFN trig
Externí odkaz:
https://doaj.org/article/779f40c2c40b44dca06f51eb6b4e0be6
Autor:
Vipul Gupta, Narendra M Dixit
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 2, p e1006004 (2018)
Eradicating HIV-1 infection is difficult because of the reservoir of latently infected cells that gets established soon after infection, remains hidden from antiretroviral drugs and host immune responses, and retains the capacity to reignite infectio
Externí odkaz:
https://doaj.org/article/4d759b337dbf42b58333e43b41df2b0f
Publikováno v:
npj Systems Biology and Applications, Vol 10, Iss 1, Pp 1-11 (2024)
Abstract Remarkable advances are being made in developing interventions for eliciting long-term remission of HIV-1 infection. The success of these interventions will obviate the need for lifelong antiretroviral therapy, the current standard-of-care,
Externí odkaz:
https://doaj.org/article/a6be965183f14f9dbca5d219b535efbc
Publikováno v:
PLoS Computational Biology, Vol 3, Iss 10, Pp 2003-2018 (2007)
The ability to accelerate the accumulation of favorable combinations of mutations renders recombination a potent force underlying the emergence of forms of HIV that escape multi-drug therapy and specific host immune responses. We present a mathematic
Externí odkaz:
https://doaj.org/article/6272fd0628874d9aa19261db8898619a