Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Narender R. Gavva"'
Autor:
Fang-Tsao Hong, Hongyan Li, Derek E. Piper, Leszek Poppe, Philip Wong, Todd Hager, Essa Hu, Jason Long, Jennifer Aral, Narender R. Gavva, Cen Xu, Les P. Miranda, Carl Davis, Dawn Zhu, Sonya G. Lehto, Licheng Shi, Kristin L. Andrews
Publikováno v:
Journal of Medicinal Chemistry. 64:3427-3438
Inhibition of the pituitary adenylate cyclase 1 receptor (PAC1R) is a novel mechanism that could be used for abortive treatment of acute migraine. Our research began with comparative analysis of known PAC1R ligand scaffolds, PACAP38 and Maxadilan, wh
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107151 (2014)
The mammalian transient receptor potential melastatin channel 8 (TRPM8) is highly expressed in trigeminal and dorsal root ganglia. TRPM8 is activated by cold temperature or compounds that cause a cooling sensation, such as menthol or icilin. TRPM8 ma
Externí odkaz:
https://doaj.org/article/bda35a7371e041359f6ffa57a92865c1
Autor:
Kristin Gabriel, Narender R. Gavva, Gabriel Vargas, Gregory E. Arnold, Chi-Ming Li, Robert W Sandrock, Edwin Lamas, Brian Smith, Miroslav Backonja, Michael T. Davis, Chris Lindvay
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Multiple genome-wide association studies have identified non-coding single-nucleotide variants (SNVs) near (e.g., rs10166942[C]) or within (rs17862920[T]) the TRPM8 gene that encodes a cold thermosensor is associated with reduced migraine risk. Furth
Autor:
Jeffrey Clarine, Qingyian Liu, Beth D. Youngblood, Chester Chenguang Yuan, Michelle Horner, James Brown, Jian J. Chen, Michael D. Bartberger, Vu Van Ma, Matthew R. Kaller, Carl D. Davis, Maosheng Zhang, Thomas T. Nguyen, Narender R. Gavva, Scott Harried, Sonya G. Lehto, Jennifer R. Allen, Holger Monenschein, Daniel B. Horne, Vijay Keshav Gore, Wenge Zhong, Kaustav Biswas
Publikováno v:
Journal of medicinal chemistry. 61(18)
Transient-receptor-potential melastatin 8 (TRPM8), the predominant mammalian cold-temperature thermosensor, is a nonselective cation channel expressed in a subpopulation of sensory neurons in the peripheral nervous system, including nerve circuitry i
Autor:
Narender R. Gavva, Gregory Dussor, Christina M. Bischoff, Weiya Wang, Carolina C. Burgos-Vega, David Dong Uk Ahn, Judy Wang, Daniel B. Horne
Publikováno v:
Cephalalgia. 36:185-193
Background Migraine headache is a neurological disorder affecting millions worldwide. However, little is known about the mechanisms contributing to migraine. Recent genome-wide association studies have found single nucleotide polymorphisms in the gen
Autor:
Cheryl L. Stucky, Patrick C. Kerstein, Maosheng Zhang, Kenneth D. Wild, Beth D. Youngblood, Carl Davis, Judy Wang, Weiya Wang, Andy D. Weyer, Sonya G. Lehto, Narender R. Gavva
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology
TRPM8 has been implicated in pain and migraine based on dorsal root- and trigeminal ganglion-enriched expression, upregulation in preclinical models of pain, knockout mouse studies, and human genetics. Here, we evaluated the therapeutic potential in
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 350:223-231
The transient receptor potential ankyrin 1 (TRPA1) channel has been implicated in different pathophysiologies that include asthma, cough, itch, and inflammatory pain. Agonists of TRPA1 such as mustard oil and its key component allyl isothiocyanate (A
Autor:
Bryan D. Moyer, Kenneth D. Wild, Beth D. Youngblood, Ruoyuan Yin, Stephanie D. Geuns-Meyer, Weiya Wang, Narender R. Gavva, Cheryl L. Stucky, Yohannes Teffera, Maosheng Zhang, Andy D. Weyer, Sonya G. Lehto, Laurie B. Schenkel, Melanie Cooke
Publikováno v:
Molecular Pain
The transient receptor potential ankyrin 1 (TRPA1) channel has been implicated in pathophysiological processes that include asthma, cough, and inflammatory pain. Agonists of TRPA1 such as mustard oil and its key component allyl isothiocyanate (AITC)
Autor:
Beth D. Youngblood, Alessandro Boezio, Stephanie D. Geuns-Meyer, Maosheng Zhang, Angel Guzman-Perez, Laurie B. Schenkel, Yohannes Teffera, Weiya Wang, Philip R. Olivieri, Renee Emkey, Hakan Gunaydin, Josie H. Lee, Holly L. Deak, Violeta Yu, Russell Graceffa, Sonya G. Lehto, Narender R. Gavva
Publikováno v:
Journal of medicinal chemistry. 59(6)
There has been significant interest in developing a transient receptor potential A1 (TRPA1) antagonist for the treatment of pain due to a wealth of data implicating its role in pain pathways. Despite this, identification of a potent small molecule to
Autor:
Sonya G. Lehto, Weiya Wang, Narender R. Gavva, Hong Deng, Mark H. Norman, Lana Klionsky, Nobuko Nishimura, Brad Youngblood, Phi Tang, Vu Van Ma, Jiyun Chen, Vijay Keshav Gore, Michael D. Bartberger, Nuria A. Tamayo, Tiffany L. Correll, Yunxin Bo
Publikováno v:
Journal of Medicinal Chemistry. 55:1593-1611
The transient receptor potential melastatin type 8 (TRPM8) is a nonselective cation channel primarily expressed in a subpopulation of sensory neurons that can be activated by a wide range of stimuli, including menthol, icilin, and cold temperatures (