Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Narender, Puli"'
Autor:
Adeniyi Michael, Adebesin, Tim, Wesser, Jonnalagadda, Vijaykumar, Anne, Konkel, Mahesh P, Paudyal, Janine, Lossie, Chen, Zhu, Christina, Westphal, Narender, Puli, Robert, Fischer, Wolf-Hagen, Schunck, John R, Falck
Publikováno v:
Journal of medicinal chemistry. 62(22)
17(
Autor:
Narender Puli, Tim Wesser, Janine Lossie, Jonnalagadda Vijaykumar, John R. Falck, Christina Westphal, Wolf-Hagen Schunck, Adeniyi Michael Adebesin, Chen Zhu, Anne Konkel, Robert Fischer, Mahesh P. Paudyal
Publikováno v:
Journal of Medicinal Chemistry.
17(R),18(S)-Epoxyeicosatetraenoic acid (EEQ) is a cytochrome P450 metabolite of eicosapentaenoic acid (EPA) and a powerful negative chronotrope with low nanomolar activity in a neonatal rat cardiomyocyte (NRCM) arrhythmia model. Prior studies identif
Autor:
Kathryn M. Gauthier, Daniel Goldman, Lawan Siangjong, John R. Falck, Ganesh Kumar, Narender Puli, William B. Campbell, Tamas Kriska, Emer M. Smyth
Publikováno v:
Acta Physiologica. 219:188-201
Aim 12/15-lipoxygenase (12/15-LO) metabolizes arachidonic acid (AA) into several vasoactive eicosanoids. In mouse arteries, we previously characterized the enzyme's 15-LO metabolites 12(S)-hydroxyeicosatetraenoic acid (HETE), 15-HETE, hydroxyepoxyeic
Autor:
Saori Inafuku, Diane R. Bielenberg, Kin Sing Stephen Lee, Deeba Husain, Bruce D. Hammock, Kaylee E. Smith, Eiichi Hasegawa, Joan W. Miller, Narender Puli, Kip M. Connor, Garrett Klokman, Wolf-Hagen Schunck, John R. Falck, Lama Mulki, Darryl C. Zeldin, Matthew L. Edin, Clifford Kim, Yoko Okunuki, Ryoji Yanai
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 114, iss 36
Age-related macular degeneration (AMD) is the most common cause of blindness for individuals age 50 and above in the developed world. Abnormal growth of choroidal blood vessels, or choroidal neovascularization (CNV), is a hallmark of the neovascular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8588a2cf79f9852dd886e79747c29bc
https://escholarship.org/uc/item/79t3243z
https://escholarship.org/uc/item/79t3243z
Autor:
Narender Puli, Jawahar L. Jat, Saroj Ranjan De, Rajkumar Manne, John R. Falck, Biao Lu, Ganesh Kumar, Adeniyi Michael Adebesin, Saritha Birudaraju
Publikováno v:
The Journal of Organic Chemistry
Methyltrioxorhenium (MTO) complexed with pyridine was shown to be a highly effective catalyst for the regioselective monoepoxidation of conjugated di- and trienes using 30% H2O2 at or below room temperature. The resultant allylic epoxides, and the tr
Publikováno v:
European Journal of Organic Chemistry. 2010:1869-1874
Nucleophilic mixed chromium(II) and chromium(III) acetylides are generated from the smooth reduction of primary 1,1,1-trichloroalkanes with chromium(II) chloride in the presence of an excess amount of triethylamine at room temperature. These species
Autor:
John R. Falck, Rajkumar Manne, William B. Campbell, Krishnam Raju Atcha, Bruce D. Hammock, Ravinder Kodela, Daniel Goldman, Narsimhaswamy Dubasi, Narender Puli, Christophe Morisseau, Jorge H. Capdevila, Vijay L. Manthati, Xiu Yu Yi
Publikováno v:
Journal of Medicinal Chemistry. 52:5069-5075
All-cis-14,15-epoxyeicosa-5,8,11-trienoic acid (14,15-EET) is a labile, vasodilatory eicosanoid generated from arachidonic acid by cytochrome P450 epoxygenases. A series of robust, partially saturated analogues containing epoxide bioisosteres were sy
Autor:
Narender Puli, John R. Falck, Hongming Zhang, Rachid Baati, D. K. Barma, Abhijit Kundu, Anyu He, Dhurke Kashinath, L. Manmohan Reddy, Anish Bandyopadhyay
Publikováno v:
Organic Letters. 11:4764-4766
A facile, one-pot reaction cascade condenses 1,1,1-trichloroalkanes with alpha,beta-unsaturated ketones to unexpectedly furnish moderate to good yields of (E)-2-alkylidenecyclobutanols.
Autor:
Narender Puli, Wolf-Hagen Schunck, Michael Rothe, Mohan Goli, Cosima Arnold, Dominik N. Müller, John R. Falck, Robert Fischer, Anne Konkel, Gerd Wallukat
17(R),18(S)-epoxyeicosatetraenoic acid [17(R),18(S)-EETeTr], a cytochrome P450 epoxygenase metabolite of eicosapentaenoic acid (EPA), exerts negative chronotropic effects and protects neonatal rat cardiomyocytes against Ca(2+)-overload with EC(50)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c07d38df4f4ef2a7fb3080c97dc221e5
https://europepmc.org/articles/PMC3122156/
https://europepmc.org/articles/PMC3122156/
Autor:
Ian A. Blair, Jatinder K. Lamba, Xianghua Luo, Julia Nguyen, David Potter, Zhijun Guo, David B. Donner, John R. Falck, Mariangellys Rodriguez, Duncan J. Clarke, Clementina Mesaros, Erin G. Schuetz, Narender Puli, Ranjana Mitra, Kalpna Gupta, Monica Milani, Jorge H. Capdevila
Publikováno v:
The Journal of biological chemistry. 286(20)
CYP3A4 expression in breast cancer correlates with decreased overall survival, but the mechanisms are unknown. Cytochrome P450 gene profiling by RNAi silencing demonstrates that CYP3A or 2C8 gene expression is specifically required for growth of the