Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Narelle Keating"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The Suppressor of Cytokine Signaling (SOCS) family proteins are important negative regulators of cytokine signaling. SOCS1 is the prototypical member of the SOCS family and functions in a classic negative-feedback loop to inhibit signaling in respons
Externí odkaz:
https://doaj.org/article/f1e2b2e01d894fef83112e58a14d5310
Autor:
Rhiannon Morris, Narelle Keating, Cyrus Tan, Hao Chen, Artem Laktyushin, Tamanna Saiyed, Nicholas P. D. Liau, Nicos A. Nicola, Tony Tiganis, Nadia J. Kershaw, Jeffrey J. Babon
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-11 (2023)
Abstract Protein Tyrosine Phosphatase 1B (PTP1B) is the prototypical protein tyrosine phosphatase and plays an essential role in the regulation of several kinase-driven signalling pathways. PTP1B displays a preference for bisphosphorylated substrates
Externí odkaz:
https://doaj.org/article/fe7ce3bae9694500a0f1ccbffabd3899
Autor:
Edmond M. Linossi, Kunlun Li, Gianluca Veggiani, Cyrus Tan, Farhad Dehkhoda, Colin Hockings, Dale J. Calleja, Narelle Keating, Rebecca Feltham, Andrew J. Brooks, Shawn S. Li, Sachdev S. Sidhu, Jeffrey J. Babon, Nadia J. Kershaw, Sandra E. Nicholson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-2 (2023)
Externí odkaz:
https://doaj.org/article/3771a83e093b48e7a5c69cac8e14f288
Autor:
Edmond M. Linossi, Kunlun Li, Gianluca Veggiani, Cyrus Tan, Farhad Dehkhoda, Colin Hockings, Dale J. Calleja, Narelle Keating, Rebecca Feltham, Andrew J. Brooks, Shawn S. Li, Sachdev S. Sidhu, Jeffrey J. Babon, Nadia J. Kershaw, Sandra E. Nicholson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Abstract Suppressor of cytokine signaling (SOCS)2 protein is a key negative regulator of the growth hormone (GH) and Janus kinase (JAK)-Signal Transducers and Activators of Transcription (STAT) signaling cascade. The central SOCS2-Src homology 2 (SH2
Externí odkaz:
https://doaj.org/article/c6fcc1c1f3344e70a63c5dfee1ef2786
Publikováno v:
Cancers, Vol 12, Iss 4, p 952 (2020)
Natural killer (NK) cells play a pivotal role in cancer immunotherapy due to their innate ability to detect and kill tumorigenic cells. The decision to kill is determined by the expression of a myriad of activating and inhibitory receptors on the NK
Externí odkaz:
https://doaj.org/article/24ca4be184294780884e225d160fe914
Autor:
Karen Doggett, Narelle Keating, Farhad Dehkhoda, Grace M. Bidgood, Evelyn Leong, Andrew Kueh, Nicos A. Nicola, Nadia J. Kershaw, Jeffrey J. Babon, Warren S. Alexander, Sandra E. Nicholson
Suppressor Of Cytokine Signaling (SOCS) 1 is a critical negative regulator of cytokine signaling and required to protect against an excessive inflammatory response. Genetic deletion ofSocs1results in unrestrained cytokine signaling and neonatal letha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fcf366146a4af56198ad20f6a8376616
https://doi.org/10.1101/2022.12.20.521329
https://doi.org/10.1101/2022.12.20.521329
Autor:
Hao Chen, Yuntong Wu, Kunlun Li, Iain Currie, Narelle Keating, Farhad Dehkhoda, Christoph Grohmann, Jeffrey J. Babon, Sandra E. Nicholson, Brad E. Sleebs
Publikováno v:
ACS Chemical Biology. 17:449-462
Suppressor of cytokine signaling 1 (SOCS1) has emerged as a potential therapeutic target in inflammatory and viral diseases. SOCS1 operates via its kinase inhibitory region, Src homology 2 (SH2) domain, and SOCS box to negatively regulate the Janus k
Autor:
Karen Doggett, Narelle Keating, Farhad Dehkhoda, Grace M. Bidgood, Lizeth G. Meza Guzman, Evelyn Leong, Andrew Kueh, Nicos A. Nicola, Nadia J. Kershaw, Jeffrey J. Babon, Warren S. Alexander, Sandra E. Nicholson
Publikováno v:
Cytokine. 165:156167
Autor:
Masato Ogishi, Andrés Augusto Arias, Rui Yang, Ji Eun Han, Peng Zhang, Darawan Rinchai, Joshua Halpern, Jeanette Mulwa, Narelle Keating, Maya Chrabieh, Candice Lainé, Yoann Seeleuthner, Noé Ramírez-Alejo, Nioosha Nekooie-Marnany, Andrea Guennoun, Ingrid Muller-Fleckenstein, Bernhard Fleckenstein, Sara S. Kilic, Yoshiyuki Minegishi, Stephan Ehl, Petra Kaiser-Labusch, Yasemin Kendir-Demirkol, Flore Rozenberg, Abderrahmane Errami, Shen-Ying Zhang, Qian Zhang, Jonathan Bohlen, Quentin Philippot, Anne Puel, Emmanuelle Jouanguy, Zahra Pourmoghaddas, Shahrzad Bakhtiar, Andre M. Willasch, Gerd Horneff, Genevieve Llanora, Lynette P. Shek, Louis Y.A. Chai, Sen Hee Tay, Hamid H. Rahimi, Seyed Alireza Mahdaviani, Serdar Nepesov, Aziz A. Bousfiha, Emine Hafize Erdeniz, Adem Karbuz, Nico Marr, Carmen Navarrete, Mehdi Adeli, Lennart Hammarstrom, Hassan Abolhassani, Nima Parvaneh, Saleh Al Muhsen, Mohammed F. Alosaimi, Fahad Alsohime, Maryam Nourizadeh, Mostafa Moin, Rand Arnaout, Saad Alshareef, Jamila El-Baghdadi, Ferah Genel, Roya Sherkat, Ayça Kiykim, Esra Yücel, Sevgi Keles, Jacinta Bustamante, Laurent Abel, Jean-Laurent Casanova, Stéphanie Boisson-Dupuis
Human cells homozygous for rare loss-of-expression (LOE) TYK2 alleles have impaired, but not abolished, cellular responses to IFN-alpha/beta (underlying viral diseases in the patients) and to IL-12 and IL-23 (underlying mycobacterial diseases). Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b84d9e1175645fc685895f3e5322af7
https://hdl.handle.net/20.500.12511/10166
https://hdl.handle.net/20.500.12511/10166
Autor:
Sandra E. Nicholson, Rebecca Feltham, Andrew J. Brooks, Nadia J. Kershaw, Colin Hockings, Cyrus Tan, Sachdev S. Sidhu, Kunlun Li, Shawn S.-C. Li, Dale J. Calleja, Farhad Dehkhoda, Narelle Keating, Edmond M. Linossi, Gianluca Veggiani, Jeffrey J. Babon
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Paediatrics Publications
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Paediatrics Publications
Suppressor of cytokine signaling (SOCS)2 protein is a key negative regulator of the growth hormone (GH) and Janus kinase (JAK)-Signal Transducers and Activators of Transcription (STAT) signaling cascade. The central SOCS2-Src homology 2 (SH2) domain