Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Narek Darabedian"'
Autor:
Narek Darabedian, Bo Yang, Richie Ding, Giuliano Cutolo, Balyn W. Zaro, Christina M. Woo, Matthew R. Pratt
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
Monosaccharide analogs bearing bioorthogonal functionalities, or metabolic chemical reporters (MCRs) of glycosylation, have been used for approximately two decades for the visualization and identification of different glycoproteins. More recently, pr
Externí odkaz:
https://doaj.org/article/9af1763064db4c8484cd82331fd5bd1c
Autor:
Weihai Liu, Yun Wang, Luiz H. M. Bozi, Patrick D. Fischer, Mark P. Jedrychowski, Haopeng Xiao, Tao Wu, Narek Darabedian, Xiadi He, Evanna L. Mills, Nils Burger, Sanghee Shin, Anita Reddy, Hans-Georg Sprenger, Nhien Tran, Sally Winther, Stephen M. Hinshaw, Jingnan Shen, Hyuk-Soo Seo, Kijun Song, Andrew Z. Xu, Luke Sebastian, Jean J. Zhao, Sirano Dhe-Paganon, Jianwei Che, Steven P. Gygi, Haribabu Arthanari, Edward T. Chouchani
Publikováno v:
Nature. 616:790-797
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fefca8c9ca13bceb27fbfc4d2e0b08ed
https://doi.org/10.1038/s41586-023-05939-3
https://doi.org/10.1038/s41586-023-05939-3
Autor:
Nageswari Yarravarapu, Rohit Sai Reddy Konada, Narek Darabedian, Nichole J. Pedowitz, Soumya N. Krishnamurthy, Matthew R. Pratt, Jennifer J. Kohler
Publikováno v:
Bioconjug Chem
Glycan binding often mediates extracellular macromolecular recognition events. Accurate characterization of these binding interactions can be difficult because of dissociation and scrambling that occur during purification and analysis steps. Use of p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::082c6963e2635aa1064f03b98fcdedc0
https://doi.org/10.1021/acs.bioconjchem.2c00037
https://doi.org/10.1021/acs.bioconjchem.2c00037
Autor:
Narek Darabedian, Wenzhi Ji, Mengyang Fan, Shan Lin, Hyuk-Soo Seo, Ekaterina V. Vinogradova, Tomer M. Yaron, Evanna L. Mills, Haopeng Xiao, Kristine Senkane, Emily M. Huntsman, Jared L. Johnson, Jianwei Che, Lewis C. Cantley, Benjamin F. Cravatt, Sirano Dhe-Paganon, Kimberly Stegmaier, Tinghu Zhang, Nathanael S. Gray, Edward T. Chouchani
Publikováno v:
Nature Chemical Biology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ba7707da9908aab038d6465277cffcb
https://doi.org/10.1038/s41589-023-01273-x
https://doi.org/10.1038/s41589-023-01273-x
Publikováno v:
Nature chemical biology
Many intracellular proteins are modified by N-acetylglucosamine, a post-translational modification termed O-GlcNAc. This modification is found on serine and threonine side chains and has the potential to regulate signaling pathways through interplay
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ba6ac0adc4c2c23dc1a9236ed3a2601
https://doi.org/10.1038/s41589-020-0640-8
https://doi.org/10.1038/s41589-020-0640-8
Autor:
Narek Darabedian, S. N. Krishnamurthy, R. S. R. Konada, Jennifer J. Kohler, Matthew R. Pratt, N. Yarravarapu, N. J. Pedowtiz
Glycan binding often mediates extracellular macromolecular recognition events. Accurate characterization of these binding interactions can be difficult because of dissociation and scrambling that occur during purification and analysis steps. Use of p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2aef1b3a620997e23ea5a534efba9c6
https://doi.org/10.1101/2021.10.07.463072
https://doi.org/10.1101/2021.10.07.463072
Autor:
Narek Darabedian, Feimeng Zhou, Ernest Enriquez, Jamil Momand, Wang Zhao, Patrycja Magdziarz, Xiaoying Wang, Chris Quan
Publikováno v:
Analytical Biochemistry. 569:53-58
Docking on the p53-binding site of murine double minute 2 (MDM2) by small molecules restores p53's tumor-suppressor function. We previously assessed 3244 FDA-approved drugs via “computational conformer selection” for inhibiting MDM2 and p53 inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b732e71e558033536f0e481ac5f85501
https://doi.org/10.1016/j.ab.2019.01.012
https://doi.org/10.1016/j.ab.2019.01.012
Autor:
Matthew R. Pratt, Alex Kim, Emily R. Forster, Xinglin Yang, Narek Darabedian, Aimee Shen, Howard C. Hang
Publikováno v:
ACS chemical biology. 15(5)
The discovery of specific microbiota metabolite mechanisms has begun to motivate new therapeutic approaches. Inspired by our mechanistic studies of microbiota-derived short chain fatty acid (SCFA) acylation of bacterial virulence factors, here we exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e91cf51394f43e4124ed82a79792c20
https://pubmed.ncbi.nlm.nih.gov/32091869
https://pubmed.ncbi.nlm.nih.gov/32091869
Publikováno v:
ACS Chemical Biology. 13:3054-3058
3-Bromopyruvate (3BP) is a potential anticancer agent viewed as a glycolytic inhibitor that preferentially kills cancer cells through inhibition of glyceraldehyde 3-phosphate dehydrogenase (GAPDH), resulting in severe energy depletion. We previously
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b3480d1b4e83cf6ec38c7a756b60d2f
https://doi.org/10.1021/acschembio.8b00743
https://doi.org/10.1021/acschembio.8b00743
Publikováno v:
Biochemistry. 57:5769-5774
The dynamic modification of intracellular proteins by O-linked β -N-acetylglucosamine (O-GlcNAcylation) plays critical roles in many cellular processes. Although various methods have been developed for O-GlcNAc detection, there are few techniques fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::555fd3f3d4c00a66a3cbd489693cac9a
https://doi.org/10.1021/acs.biochem.8b00648
https://doi.org/10.1021/acs.biochem.8b00648