Early enterovirus translation deficits extend viral RNA replication and elicit sustained MDA5-directed innate signaling.

Autor: Dobrikov MI; Department of Neurosurgery, Duke University Medical School, Durham, North Carolina, USA., Dobrikova EY; Department of Neurosurgery, Duke University Medical School, Durham, North Carolina, USA., Nardone-White DT; Department of Neurosurgery, Duke University Medical School, Durham, North Carolina, USA.; Department of Molecular Genetics and Microbiology, Duke University Medical School, Durham, North Carolina, USA., McKay ZP; Department of Neurosurgery, Duke University Medical School, Durham, North Carolina, USA., Brown MC; Department of Neurosurgery, Duke University Medical School, Durham, North Carolina, USA., Gromeier M; Department of Neurosurgery, Duke University Medical School, Durham, North Carolina, USA.; Department of Molecular Genetics and Microbiology, Duke University Medical School, Durham, North Carolina, USA.

Publikováno v: MBio [mBio] 2023 Dec 19; Vol. 14 (6), pp. e0191523. Date of Electronic Publication: 2023 Nov 14.

Detoxication versus Bioactivation Pathways of Lapatinib In Vitro: UGT1A1 Catalyzes the Hepatic Glucuronidation of Debenzylated Lapatinib.

Autor: Nardone-White DT; Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (D.T.N.-W., K.D.J.) and Department of Pharmaceutical Sciences, Lipscomb University College of Pharmacy and Health Sciences, Nashville, Tennessee (J.E.B., A.A.A.)., Bissada JE; Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (D.T.N.-W., K.D.J.) and Department of Pharmaceutical Sciences, Lipscomb University College of Pharmacy and Health Sciences, Nashville, Tennessee (J.E.B., A.A.A.)., Abouda AA; Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (D.T.N.-W., K.D.J.) and Department of Pharmaceutical Sciences, Lipscomb University College of Pharmacy and Health Sciences, Nashville, Tennessee (J.E.B., A.A.A.)., Jackson KD; Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (D.T.N.-W., K.D.J.) and Department of Pharmaceutical Sciences, Lipscomb University College of Pharmacy and Health Sciences, Nashville, Tennessee (J.E.B., A.A.A.) klarissa.jackson@unc.edu.

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2021 Mar; Vol. 49 (3), pp. 233-244. Date of Electronic Publication: 2020 Dec 29.