Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Narda Mertens"'
Autor:
Wim Albert Alex Aelterman, Dominic Ormerod, Albert Willemsens, Carlos Perez-Balado, Narda Mertens
Publikováno v:
Organic Process Research & Development. 11:237-240
A practical and scaleable synthesis of 2-chloro-5-(pyridin-2-yl) pyrimidine, an intermediate in the synthesis of a selective PDE-V inhibitor, was developed. A Negishi cross-coupling between the in situ prepared 2-pyridylzinc chloride and 5-iodo-2-chl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d014898583a6c8ff0e850f2a759b7b60
https://doi.org/10.1021/op060241c
https://doi.org/10.1021/op060241c
Autor:
István E. Markó, Dominique Ormerod, Sébastien Lemaire, Wim Albert Alex Aelterman, Ivan Vervest, Christine Fannes, Narda Mertens, Bert Willemsens
Publikováno v:
Organic Process Research & Development. 10:1275-1281
A scalable and safe process for the oxidative rearrangement of beta-carboline to quinolone derivatives, intermediates in the synthesis of PDE-V inhibitors RWJ387273 (R301249) and RWJ444772 (R290629), has been developed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4301e5bd6254f68a0e94dd00fbc55cb7
https://doi.org/10.1021/op060099f
https://doi.org/10.1021/op060099f
Publikováno v:
Organic Process Research & Development; Mar2007, Vol. 11 Issue 2, p237-240, 4p