Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Narcis Fernandez‐Fuentes"'
Defective ribosome assembly impairs leukemia progression in a murine model of acute myeloid leukemia
Autor:
Daniel Sjövall, Sudip Ghosh, Narcis Fernandez-Fuentes, Talia Velasco-Hernandez, Anna Hogmalm, Pablo Menendez, Jenny Hansson, Carolina Guibentif, Pekka Jaako
Publikováno v:
Cell Reports, Vol 43, Iss 11, Pp 114864- (2024)
Summary: Despite an advanced understanding of disease mechanisms, the current therapeutic regimen fails to cure most patients with acute myeloid leukemia (AML). In the present study, we address the role of ribosome assembly in leukemia cell function.
Externí odkaz:
https://doaj.org/article/7e96c7701be34955b127ae9cdf7969c3
Autor:
José Luis Villanueva-Cañas, Narcis Fernandez-Fuentes, Dominik Saul, Robyn Laura Kosinsky, Catherine Teyssier, Malgorzata Ewa Rogalska, Ferran Pegenaute Pérez, Baldomero Oliva, Cedric Notredame, Miguel Beato, Priyanka Sharma
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109584- (2024)
Summary: Peptidyl arginine deiminases (PADIs) catalyze protein citrullination, a post-translational conversion of arginine to citrulline. The most widely expressed member of this family, PADI2, regulates cellular processes that impact several disease
Externí odkaz:
https://doaj.org/article/dcca59766b1249ce963e9b46e07add27
Autor:
Linda B. Oyama, Hamza Olleik, Ana Carolina Nery Teixeira, Matheus M. Guidini, James A. Pickup, Brandon Yeo Pei Hui, Nicolas Vidal, Alan R. Cookson, Hannah Vallin, Toby Wilkinson, Denise M. S. Bazzolli, Jennifer Richards, Mandy Wootton, Ralf Mikut, Kai Hilpert, Marc Maresca, Josette Perrier, Matthias Hess, Hilario C. Mantovani, Narcis Fernandez-Fuentes, Christopher J. Creevey, Sharon A. Huws
Publikováno v:
npj Biofilms and Microbiomes, Vol 8, Iss 1, Pp 1-14 (2022)
Abstract Here we report two antimicrobial peptides (AMPs), HG2 and HG4 identified from a rumen microbiome metagenomic dataset, with activity against multidrug-resistant (MDR) bacteria, especially methicillin-resistant Staphylococcus aureus (MRSA) str
Externí odkaz:
https://doaj.org/article/c23c7ade54b24fadb7cc4ad66c299983
Publikováno v:
Frontiers in Bioinformatics, Vol 2 (2022)
Drug discovery attrition rates, particularly at advanced clinical trial stages, are high because of unexpected adverse drug reactions (ADR) elicited by novel drug candidates. Predicting undesirable ADRs produced by the modulation of certain protein t
Externí odkaz:
https://doaj.org/article/ada394d460d342ef9ed505ea758039d6
Autor:
Lucy A. Onime, Linda B. Oyama, Benjamin J. Thomas, Jurnorain Gani, Peter Alexander, Kate E. Waddams, Alan Cookson, Narcis Fernandez-Fuentes, Christopher J. Creevey, Sharon A. Huws
Publikováno v:
BMC Microbiology, Vol 21, Iss 1, Pp 1-13 (2021)
Abstract Background The rise of microbial antibiotic resistance is a leading threat to the health of the human population. As such, finding new approaches to tackle these microbes, including development of novel antibiotics is vital. Results In this
Externí odkaz:
https://doaj.org/article/fcc8b0421b594db98e62210df27df62d
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
During pre-Replication Complex, eukaryotic cells load two MCMs into a head-to-head Double Hexamer around duplex DNA (DH). Here the authors preRC assembly assay with purified proteins to reveal insights into S. cerevisiae’s first steps that lead to
Externí odkaz:
https://doaj.org/article/2a3a272cd120490cb93389b9e9ed49dd
Autor:
Joaquim Aguirre-Plans, Alberto Meseguer, Ruben Molina-Fernandez, Manuel Alejandro Marín-López, Gaurav Jumde, Kevin Casanova, Jaume Bonet, Oriol Fornes, Narcis Fernandez-Fuentes, Baldo Oliva
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-13 (2021)
Abstract Background Statistical potentials, also named knowledge-based potentials, are scoring functions derived from empirical data that can be used to evaluate the quality of protein folds and protein–protein interaction (PPI) structures. In prev
Externí odkaz:
https://doaj.org/article/ff7abf755f1547e99688b9b85deb9be8
Autor:
Joaquim Aguirre-Plans, Janet Piñero, Terezinha Souza, Giulia Callegaro, Steven J. Kunnen, Ferran Sanz, Narcis Fernandez-Fuentes, Laura I. Furlong, Emre Guney, Baldo Oliva
Publikováno v:
Biology Direct, Vol 16, Iss 1, Pp 1-14 (2021)
Abstract Background Drug-induced liver injury (DILI) is an adverse reaction caused by the intake of drugs of common use that produces liver damage. The impact of DILI is estimated to affect around 20 in 100,000 inhabitants worldwide each year. Despit
Externí odkaz:
https://doaj.org/article/f3a04f85cfdc43a285f9e1510aef32f2
Autor:
Jose J. De Vega, Robert P. Davey, Jorge Duitama, Dairo Escobar, Marco A. Cristancho‐Ardila, Graham J. Etherington, Alice Minotto, Nelson E. Arenas‐Suarez, Juan D. Pineda‐Cardenas, Javier Correa‐Alvarez, Anyela V. Camargo Rodriguez, Wilfried Haerty, Juan P. Mallarino‐Robayo, Emiliano Barreto‐Hernandez, Monica Muñoz‐Torres, Narcis Fernandez‐Fuentes, Federica Di Palma, the Colombian Cyberinfrastructure Consortium for Biodiversity
Publikováno v:
Plants, People, Planet, Vol 2, Iss 3, Pp 229-236 (2020)
Societal Impact Statement Colombia is a “megadiverse” country with vast natural resources. A history of recent conflict means that information is only now being collected on the natural capital of regions that were previously unexplored. Better a
Externí odkaz:
https://doaj.org/article/7e482cb2bcd3451cb981794321201737
Autor:
Charlotte Jones, Jose De Vega, Margaret Worthington, Ann Thomas, Dagmara Gasior, John Harper, John Doonan, Yuan Fu, Maurice Bosch, Fiona Corke, Jacobo Arango, Juan Andres Cardoso, Juan de la Cruz Jimenez, Ian Armstead, Narcis Fernandez-Fuentes
Publikováno v:
Frontiers in Plant Science, Vol 12 (2021)
Brachiaria (Trin.) Griseb. (syn. Urochloa P. Beauv.) is a C4 grass genus belonging to the Panicoideae. Native to Africa, these grasses are now widely grown as forages in tropical areas worldwide and are the subject of intensive breeding, particularly
Externí odkaz:
https://doaj.org/article/bb3df03eec6541d6a09d0fb54b899dc6