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Publikováno v:
iScience, Vol 24, Iss 3, Pp 102138- (2021)
Summary: Broad evidence in the literature supports double-strand breaks (DSBs) as initiators of mitochondrial DNA (mtDNA) deletion mutations. While DNA misalignment during DSB repair is commonly proposed as the mechanism by which DSBs cause deletion
Externí odkaz:
https://doaj.org/article/bd7b4659737640a7abdaa97799015f18
Autor:
Johann S, Hawe, Rory, Wilson, Katharina T, Schmid, Li, Zhou, Lakshmi Narayanan, Lakshmanan, Benjamin C, Lehne, Brigitte, Kühnel, William R, Scott, Matthias, Wielscher, Yik Weng, Yew, Clemens, Baumbach, Dominic P, Lee, Eirini, Marouli, Manon, Bernard, Liliane, Pfeiffer, Pamela R, Matías-García, Matias I, Autio, Stephane, Bourgeois, Christian, Herder, Ville, Karhunen, Thomas, Meitinger, Holger, Prokisch, Wolfgang, Rathmann, Michael, Roden, Sylvain, Sebert, Jean, Shin, Konstantin, Strauch, Weihua, Zhang, Wilson L W, Tan, Stefanie M, Hauck, Juliane, Merl-Pham, Harald, Grallert, Eudes G V, Barbosa, Thomas, Illig, Annette, Peters, Tomas, Paus, Zdenka, Pausova, Panos, Deloukas, Roger S Y, Foo, Marjo-Riitta, Jarvelin, Jaspal S, Kooner, Marie, Loh, Matthias, Heinig, Christian, Gieger, Melanie, Waldenberger, Krina T, Zondervan
Publikováno v:
Nat. Genet. 54, 18–29 (2022)
We determined the relationships between DNA sequence variation and DNA methylation using blood samples from 3,799 Europeans and 3,195 South Asians. We identify 11,165,559 SNP-CpG associations (methylation quantitative trait loci (meQTL), P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f854cdd047ff8e3bf4d76fef7f78d2a7
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=64018
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=64018
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35271 (2012)
Deletion mutations within mitochondrial DNA (mtDNA) have been implicated in degenerative and aging related conditions, such as sarcopenia and neuro-degeneration. While the precise molecular mechanism of deletion formation in mtDNA is still not comple
Externí odkaz:
https://doaj.org/article/316a80c621c04442a4cb787dd0ba1918
Autor:
Rudiyanto Gunawan, Barry Halliwell, Lakshmi Narayanan Lakshmanan, Suresh Poovathingal, Jan Gruber
Publikováno v:
Biogerontology, 13 (5)
Biogerontology, 13 (5)
ISSN:1389-5729
ISSN:1573-6768
ISSN:1389-5729
ISSN:1573-6768
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72432890e52412c224c14b571982757d
http://doc.rero.ch/record/315112/files/10522_2012_Article_9390.pdf
http://doc.rero.ch/record/315112/files/10522_2012_Article_9390.pdf
Broad evidence support double-strand breaks (DSBs) as initiators of mitochondrial DNA (mtDNA) deletion mutations. But the mechanism of DSB-induced deletions, including the DSB repair pathway(s) involved, remains to be established. Here, we used DNA h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c78123e7dbfffbada9c1295c51b990c
https://doi.org/10.1101/254631
https://doi.org/10.1101/254631
Autor:
Zhuangli Yee, Lakshmi Narayanan Lakshmanan, Jan Gruber, Rudiyanto Gunawan, Barry Halliwell, Li Fang Ng
Publikováno v:
Aging Cell, 17 (5)
Aging Cell
Aging Cell
Disruption of mitochondrial metabolism and loss of mitochondrial DNA (mtDNA) integrity are widely considered as evolutionarily conserved (public) mechanisms of aging (López‐Otín et al., Cell, 153, 2013 and 1194). Human aging is associated with lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ac0ecd04c69d4e27aa6ddf2adddf8be
https://doi.org/10.1111/acel.12814
https://doi.org/10.1111/acel.12814
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35271 (2012)
PLoS ONE
PLoS ONE
Deletion mutations within mitochondrial DNA (mtDNA) have been implicated in degenerative and aging related conditions, such as sarcopenia and neuro-degeneration. While the precise molecular mechanism of deletion formation in mtDNA is still not comple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78fdcd4f1823ef57c77035eb3f1cc6ac
https://doi.org/10.1371/journal.pone.0035271
https://doi.org/10.1371/journal.pone.0035271
Publikováno v:
Journal of the Structural Division. 102:1337-1352
An analysis for predicting the torsional capacity of reinforced concrete beams has been developed based on consideration of deformations and equilibrium at failure. Three main factors are identified as contributing to the torque capacity of a section
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f451ea996ca97c780bffc52cca4e76f
https://doi.org/10.1061/jsdeag.0004385
https://doi.org/10.1061/jsdeag.0004385
Publikováno v:
Journal of the Geotechnical Engineering Division. 103:662-663
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::479e0796d0c64d73566e0b20162af3df
https://doi.org/10.1061/ajgeb6.0000444
https://doi.org/10.1061/ajgeb6.0000444