Mapping the self-association domains of ataxin-1: identification of novel non overlapping motifs

Autor: Rajesh P. Menon, Daniel Soong, Cesira de Chiara, Mark Holt, John E. McCormick, Narayana Anilkumar, Annalisa Pastore

Publikováno v: PeerJ, Vol 2, p e323 (2014)

The neurodegenerative disease spinocerebellar ataxia type 1 (SCA1) is caused by aggregation and misfolding of the ataxin-1 protein. While the pathology correlates with mutations that lead to expansion of a polyglutamine tract in the protein, other re

Externí odkaz: https://doaj.org/article/fe885deeb75747f499782483eef48fa5

NADPH oxidase 4 regulates homocysteine metabolism and protects against acetaminophen-induced liver damage in mice

Autor: Anna Caldwell, Ralf P. Brandes, John M. Halket, Alison C. Brewer, Tracy Dew, Roy Sherwood, Katrin Schröder, Ajay M. Shah, Thomas V.A. Murray, Daniel Martin, Alberto Quaglia, Rajesh K. Mistry, Robin D. Hughes, Xuebin Dong, Greta J. Sawyer, Narayana Anilkumar, Simon Burr

Publikováno v: Free Radical Biology & Medicine

Glutathione is the major intracellular redox buffer in the liver and is critical for hepatic detoxification of xenobiotics and other environmental toxins. Hepatic glutathione is also a major systemic store for other organs and thus impacts on patholo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::520c717b1d4bf4b2c6a558abecebf0e4
https://doi.org/10.1016/j.freeradbiomed.2015.09.015

Endothelial Nox4 NADPH Oxidase Enhances Vasodilatation and Reduces Blood Pressure In Vivo

Autor: Alexandre Ouattara, David J. Grieve, Robin Ray, Alison C. Brewer, Rebecca L. Charles, Alison C. Cave, Colin E. Murdoch, Ajay M. Shah, Narayana Anilkumar, Min Zhang, Sara P. Alom-Ruiz, Philip Eaton, Minshu Wang, Celio X.C. Santos, Simon Walker

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 31:1368-1376

Objective— Increased reactive oxygen species (ROS) production is involved in the pathophysiology of endothelial dysfunction. NADPH oxidase-4 (Nox4) is a ROS-generating enzyme expressed in the endothelium, levels of which increase in pathological se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d97feb1a9dc56003321153bcbd2b099
https://doi.org/10.1161/atvbaha.110.219238

Cardiomyocytes Sense Matrix Rigidity through a Combination of Muscle and Non-muscle Myosin Contractions

Autor: Liisa M. Hirvonen, Pragati Pandey, Narayana Anilkumar, James Hone, Thomas Iskratsch, Michael P. Sheetz, Elisabeth Ehler, William Megone, William Hawkes, Junquiang Hu, Min Zhang, Julien E. Gautrot, Susan Cox

Publikováno v: Developmental Cell
Pandey, P, Hawkes, W, Hu, J, Megone, W V, Gautrot, J, Anilkumar, N, Zhang, M, Hirvonen, L, Cox, S, Ehler, E, Hone, J, Sheetz, M & Iskratsch, T 2018, ' Cardiomyocytes Sense Matrix Rigidity through a Combination of Muscle and Non-muscle Myosin Contractions ', Developmental Cell, vol. 44, no. 3, pp. 326-336 . https://doi.org/10.1016/j.devcel.2017.12.024

Summary Mechanical properties are cues for many biological processes in health or disease. In the heart, changes to the extracellular matrix composition and cross-linking result in stiffening of the cellular microenvironment during development. Moreo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30addc32b09d5dda706a3e8f4e82b849
http://europepmc.org/articles/PMC5807060

Nox4 and Nox2 NADPH Oxidases Mediate Distinct Cellular Redox Signaling Responses to Agonist Stimulation

Autor: Alison C. Brewer, Ajay M. Shah, Narayana Anilkumar, Min Zhang, Roberta Weber

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 28:1347-1354

Objectives— The NADPH oxidase isoforms Nox2 and Nox4 are coexpressed in many cell types and are implicated in agonist-stimulated redox-sensitive signal transduction. We compared the involvement of Nox2 versus Nox4 in redox-sensitive protein kinase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e1d1c79ae4b8f6d2bd998b2fd877202
https://doi.org/10.1161/atvbaha.108.164277