Zobrazeno 1 - 10
of 191
pro vyhledávání: '"Narayan G. Avadhani"'
Autor:
Takashi Kijima, Hiroshi Nakagawa, Masataka Shimonosono, Prasanna M. Chandramouleeswaran, Takeo Hara, Varun Sahu, Yuta Kasagi, Osamu Kikuchi, Koji Tanaka, Veronique Giroux, Amanda B. Muir, Kelly A. Whelan, Shinya Ohashi, Seiji Naganuma, Andres J. Klein-Szanto, Yoshiaki Shinden, Ken Sasaki, Itaru Omoto, Yoshiaki Kita, Manabu Muto, Adam J. Bass, J. Alan Diehl, Gregory G. Ginsberg, Yuichiro Doki, Masaki Mori, Yasuto Uchikado, Takaaki Arigami, Narayan G. Avadhani, Devraj Basu, Anil K. Rustgi, Shoji Natsugoe
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 1, Pp 73-91 (2019)
Background & Aims: Oropharyngeal and esophageal squamous cell carcinomas, especially the latter, are a lethal disease, featuring intratumoral cancer cell heterogeneity and therapy resistance. To facilitate cancer therapy in personalized medicine, thr
Externí odkaz:
https://doaj.org/article/7488edc6ab024bcda04958703e1f2938
Autor:
Anindya Roy Chowdhury, Jacek Zielonka, Balaraman Kalyanaraman, Richard C. Hartley, Michael P. Murphy, Narayan G. Avadhani
Publikováno v:
Redox Biology, Vol 36, Iss , Pp 101606- (2020)
The mitochondrial electron transport chain is a major source of reactive oxygen species (ROS) and is also a target of ROS, with an implied role in the stabilization of hypoxia-inducible factor (HIF) and induction of the AMPK pathway. Here we used var
Externí odkaz:
https://doaj.org/article/58c1fa1d4a5f46729fb31d06fda46e76
Autor:
Anindya Roy Chowdhury, Satish Srinivasan, György Csordás, György Hajnóczky, Narayan G. Avadhani
Publikováno v:
iScience, Vol 23, Iss 8, Pp 101370- (2020)
Summary: This study shows that multiple modes of mitochondrial stress generated by partial mtDNA depletion or cytochrome c oxidase disruption cause ryanodine receptor channel (RyR) dysregulation, which instigates the release of Ca2+ in the cytoplasm
Externí odkaz:
https://doaj.org/article/924abfb694954dbebaa357b1e2bbaf5d
Defects in cytochrome c oxidase expression induce a metabolic shift to glycolysis and carcinogenesis
Publikováno v:
Genomics Data, Vol 6, Iss C, Pp 99-107 (2015)
Mitochondrial metabolic dysfunction is often seen in cancers. This paper shows that the defect in a mitochondrial electron transport component, the cytochrome c oxidase (CcO), leads to increased glycolysis and carcinogenesis. Using whole genome micro
Externí odkaz:
https://doaj.org/article/30cd95efa608444995a74c8620846d3e
Publikováno v:
Redox Biology, Vol 2, Iss C, Pp 273-283 (2014)
The inducible form of Heme Oxygenase-1 (HO-1), a major endoplasmic reticulum (ER) associated heme protein, is known to play important roles in protection against oxidative and chemical stress by degrading free heme released from degradation of heme p
Externí odkaz:
https://doaj.org/article/dc5a04f2c56a4ae88103ac1e02e13f5f
Publikováno v:
International Journal of Molecular Sciences, Vol 12, Iss 5, Pp 3133-3147 (2011)
We have previously shown a tissue-specific increase in oxidative stress in the early stages of streptozotocin (STZ)-induced diabetic rats. In this study, we investigated oxidative stress-related long-term complications and mitochondrial dysfunctions
Externí odkaz:
https://doaj.org/article/1a0dc2c7210c4638b41c94d65eaa0bc3
Autor:
Hiroshi Nakagawa, Takashi Kijima, Andres J. Klein-Szanto, Koji Tanaka, Kelly A. Whelan, Prasanna M. Chandramouleeswaran, Manti Guha, Gordon Ruthel, Satish Srinivasan, Narayan G. Avadhani, Maura M. Sheehan
Publikováno v:
Oncotarget
Esophageal squamous cell carcinoma (ESCC) is an aggressive cancer with late-stage detection and poor prognosis. This emphasizes the need to identify new markers for early diagnosis and treatment. Altered mitochondrial genome (mtDNA) content in primar
Autor:
Narayan G. Avadhani, Takashi Kijima, Jameel Iqbal, Mone Zaidi, Manti Guha, Tony Yuen, Rajesh Angireddy, Satish Srinivasan, Serge Y. Fuchs, Li Sun, Hasan Raza Kazmi
Publikováno v:
FASEB J
The mitochondria-to-nucleus retrograde signaling (MtRS) pathway aids in cellular adaptation to stress. We earlier reported that the Ca(2+)- and calcineurin-dependent MtRS induces macrophage differentiation to bone-resorbing osteoclasts. However, mech
Autor:
Manabu Muto, Masataka Shimonosono, Takaaki Arigami, Amanda B. Muir, Masaki Mori, Takashi Kijima, Yuta Kasagi, Shinya Ohashi, Andres J. Klein-Szanto, Prasanna M. Chandramouleeswaran, Narayan G. Avadhani, Itaru Omoto, Shoji Natsugoe, Gregory G. Ginsberg, Seiji Naganuma, Veronique Giroux, Varun Sahu, Yoshiaki Shinden, Osamu Kikuchi, Devraj Basu, J. Alan Diehl, Yasuto Uchikado, Koji Tanaka, Yoshiaki Kita, Yuichiro Doki, Adam J. Bass, Ken Sasaki, Hiroshi Nakagawa, Anil K. Rustgi, Kelly A. Whelan, Takeo Hara
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 1, Pp 73-91 (2019)
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 1, Pp 73-91 (2019)
Background & Aims Oropharyngeal and esophageal squamous cell carcinomas, especially the latter, are a lethal disease, featuring intratumoral cancer cell heterogeneity and therapy resistance. To facilitate cancer therapy in personalized medicine, thre