Zobrazeno 1 - 10
of 222
pro vyhledávání: '"Narayan, Shivapurkar"'
Autor:
Victor Ciofoaia, Wenqiang Chen, Bakain W. Tarek, Martha Gay, Narayan Shivapurkar, Jill P. Smith
Publikováno v:
Pharmaceutics, Vol 16, Iss 5, p 611 (2024)
Chronic pancreatitis (CP) is a rare but debilitating condition with an 8-fold increased risk of developing pancreatic cancer. In addition to the symptoms that come from the loss of endocrine and exocrine function in CP, the management of chronic pain
Externí odkaz:
https://doaj.org/article/b4cc7916f9ea4ff38346bfc84275c579
Publikováno v:
Cancer letters [Cancer Lett] 2015 Apr 28; Vol. 360 (1), pp. 87.
Autor:
Narayan Shivapurkar, Martha D. Gay, Aiwu (Ruth) He, Wenqiang Chen, Shermineh Golnazar, Hong Cao, Tetyana Duka, Bhaskar Kallakury, Sona Vasudevan, Jill P. Smith
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3625 (2023)
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-associated deaths worldwide. Treatment with immune checkpoint antibodies has shown promise in advanced HCC, but the response is only 15–20%. We discovered a potential target for th
Externí odkaz:
https://doaj.org/article/19a37e1903aa4685bf1c0db5270a6405
Autor:
Jill P. Smith, Wenqiang Chen, Narayan Shivapurkar, Monica Gerber, Robin D. Tucker, Bhaskar Kallakury, Siva Sai Krishna Dasa, Ruvanthi N. Kularatne, Stephan T. Stern
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 1, p 752 (2023)
Survival from pancreatic cancer is poor because most cancers are diagnosed in the late stages and there are no therapies to prevent the progression of precancerous pancreatic intraepithelial neoplasms (PanINs). Inhibiting mutant KRASG12D, the primary
Externí odkaz:
https://doaj.org/article/1a838750f15e4ec4a8e43ea0fe2a32b3
Autor:
Martha D. Gay, Hong Cao, Narayan Shivapurkar, Sivanesan Dakshanamurthy, Bhaskar Kallakury, Robin D. Tucker, John Kwagyan, Jill P. Smith
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1899 (2022)
Nonalcoholic steatohepatitis (NASH) is associated with obesity, metabolic syndrome, and dysbiosis of the gut microbiome. Cholecystokinin (CCK) is released by saturated fats and plays an important role in bile acid secretion. CCK receptors are express
Externí odkaz:
https://doaj.org/article/af392019a9d643e09082390367ed310d
Autor:
Julian Burks, Sandeep Nadella, Abdullah Mahmud, Charoen Mankongpaisarnrung, Juan Wang, Jong-In Hahm, Robin D. Tucker, Narayan Shivapurkar, Stephan T. Stern, Jill P. Smith
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 6, Iss 1, Pp 17-32 (2018)
Pancreatic ductal adenocarcinoma (PDAC) remains the most aggressive malignancy with the lowest 5-year survival rate of all cancers in part owing to the lack of tumor-specific therapy and the rapid metastatic nature of this cancer. The gastrointestina
Externí odkaz:
https://doaj.org/article/2b74bdbfe6f94384abdd7ecb6ed5e1b1
Autor:
Gurbani Jolly, Tetyana Duka, Narayan Shivapurkar, Wenqiang Chen, Sunil Bansal, Amrita Cheema, Jill P. Smith
Publikováno v:
Cancers; Volume 15; Issue 10; Pages: 2811
CCK receptors are expressed on pancreatic cancer epithelial cells, and blockade with receptor antagonists decreases tumor growth. Activated pancreatic stellate cells or myofibroblasts have also been described to express CCK receptors, but the contrib
Publikováno v:
Physiology. 38
Introduction: Hepatocellular carcinoma (HCC) remains one of the leading causes of cancer-related deaths worldwide. Although the cellular origin of HCC remains uncertain, the self-renewal capacity of the liver after injury suggests that it may arise f
Publikováno v:
Clinical and Translational Medicine, Vol 6, Iss 1, Pp 1-10 (2017)
Abstract Background Serial analysis of biomarkers in the circulation of patients undergoing treatment (“liquid biopsies”) can provide new insights into drug effects. In particular the analysis of cell-free, circulating nucleic acids such as micro
Externí odkaz:
https://doaj.org/article/4e8fe86b0417486c92c79869cb949453
Autor:
Martha Gay, Anita Safronenka, Hong Cao, Robin Tucker, Narayan Shivapurkar, Annie Kruger, Jill Smith
Publikováno v:
Journal of Clinical and Translational Science, Vol 4, Pp 93-94 (2020)
OBJECTIVES/GOALS: NASH increases the risk of cirrhosis and liver cancer. High-fat diets increase CCK levels and CCK receptors have been identified on fibroblasts and immune cells. We hypothesized that CCK receptor blockade could prevent NASH by alter
Externí odkaz:
https://doaj.org/article/72c4cc2b2f2c467bb923e2f67e0773d9