Výsledky vyhledávání - "Narasimhulu Simma"

Immunosuppression by N-Methyl-d-Aspartate Receptor Antagonists Is Mediated through Inhibition of Kv1.3 and KCa3.1 Channels in T Cells

Autor: Rolf Sprengel, Narasimhulu Simma, Ursula Bommhardt, Theresa Lowinus, Judith Mankiewicz, Martin Heine, Stefan Klein-Hessling, Sascha Kahlfuß, Tanima Bose, Burkhart Schraven

N-methyl-D-aspartate receptors (NMDARs) are ligand-gated ion channels that play an important role in neuronal development, plasticity, and excitotoxicity. NMDAR antagonists are neuroprotective in animal models of neuronal diseases, and the NMDAR open

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cf22f372063470506441cccb466643d
https://europepmc.org/articles/PMC4023824/

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Constitutive Akt1 signals attenuate B-cell receptor signaling and proliferation, but enhance B-cell migration and effector function

Autor: Mandy, Pierau, Shin-Young, Na, Narasimhulu, Simma, Theresa, Lowinus, Alexander, Marx, Burkhart, Schraven, Ursula H, Bommhardt

Publikováno v: European journal of immunology. 42(12)

Ligation of the BCR induces a complex signaling network that involves activation of Akt, a family of serine/threonine protein kinases associated with B-cell development, proliferation, and tumor formation. Here, we analyzed the effect of enhanced Akt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3e0c67baa49914f0b2f29c7b65c87b80
https://pubmed.ncbi.nlm.nih.gov/22930469

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