Zobrazeno 1 - 10
of 9 654
pro vyhledávání: '"Narasimhan P"'
Autor:
Christopher S. Hackett, Daniel Hirschhorn, Meixian S. Tang, Terence J. Purdon, Yacine Marouf, Alessandra Piersigilli, Narasimhan P. Agaram, Cailian Liu, Sara E. Schad, Elisa de Stanchina, Sarwish Rafiq, Sebastien Monette, Jedd D. Wolchok, Taha Merghoub, Renier J. Brentjens
Publikováno v:
Molecular Therapy: Oncology, Vol 32, Iss 3, Pp 200862- (2024)
Despite therapeutic efficacy observed with immune checkpoint blockade in advanced melanoma, many tumors do not respond to treatment, representing a need for new therapies. Here, we have generated chimeric antigen receptor (CAR) T cells targeting TYRP
Externí odkaz:
https://doaj.org/article/50d77f52a8984498bb99701a99596c2c
Autor:
Benjamin A. Nacev, Francisco Sanchez-Vega, Shaleigh A. Smith, Cristina R. Antonescu, Evan Rosenbaum, Hongyu Shi, Cerise Tang, Nicholas D. Socci, Satshil Rana, Rodrigo Gularte-Mérida, Ahmet Zehir, Mrinal M. Gounder, Timothy G. Bowler, Anisha Luthra, Bhumika Jadeja, Azusa Okada, Jonathan A. Strong, Jake Stoller, Jason E. Chan, Ping Chi, Sandra P. D’Angelo, Mark A. Dickson, Ciara M. Kelly, Mary Louise Keohan, Sujana Movva, Katherine Thornton, Paul A. Meyers, Leonard H. Wexler, Emily K. Slotkin, Julia L. Glade Bender, Neerav N. Shukla, Martee L. Hensley, John H. Healey, Michael P. La Quaglia, Kaled M. Alektiar, Aimee M. Crago, Sam S. Yoon, Brian R. Untch, Sarah Chiang, Narasimhan P. Agaram, Meera R. Hameed, Michael F. Berger, David B. Solit, Nikolaus Schultz, Marc Ladanyi, Samuel Singer, William D. Tap
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Sarcomas are rare tumours with many different subtypes and clinical outcomes; a broader knowledge of their genetic features is required. Here, the authors analyse 2138 soft tissue and bone sarcomas across 45 subtypes using MSK-IMPACT targeted sequenc
Externí odkaz:
https://doaj.org/article/89c42dddd0f647ee90d7805699d564f6
Autor:
Sandra P. D’Angelo, Allison L. Richards, Anthony P. Conley, Hyung Jun Woo, Mark A. Dickson, Mrinal Gounder, Ciara Kelly, Mary Louise Keohan, Sujana Movva, Katherine Thornton, Evan Rosenbaum, Ping Chi, Benjamin Nacev, Jason E. Chan, Emily K. Slotkin, Hannah Kiesler, Travis Adamson, Lilan Ling, Pavitra Rao, Shreyaskumar Patel, Jonathan A. Livingston, Samuel Singer, Narasimhan P. Agaram, Cristina R. Antonescu, Andrew Koff, Joseph P. Erinjeri, Sinchun Hwang, Li-Xuan Qin, Mark T. A. Donoghue, William D. Tap
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
The activity of PD-1 blockade in patients with sarcoma has been modest so far. Here, the authors report the results of a pilot clinical trial to assess the efficacy and safety of bempegaldesleukin, a CD122-preferential interleukin-2 (IL-2) pathway ag
Externí odkaz:
https://doaj.org/article/b6788f9bd032450d95559d4440fb175b
Autor:
Mrinal M. Gounder, Narasimhan P. Agaram, Sally E. Trabucco, Victoria Robinson, Richard A. Ferraro, Sherri Z. Millis, Anita Krishnan, Jessica Lee, Steven Attia, Wassim Abida, Alexander Drilon, Ping Chi, Sandra P. D’ Angelo, Mark A. Dickson, Mary Lou Keohan, Ciara M. Kelly, Mark Agulnik, Sant P. Chawla, Edwin Choy, Rashmi Chugh, Christian F. Meyer, Parvathi A. Myer, Jessica L. Moore, Ross A. Okimoto, Raphael E. Pollock, Vinod Ravi, Arun S. Singh, Neeta Somaiah, Andrew J. Wagner, John H. Healey, Garrett M. Frampton, Jeffrey M. Venstrom, Jeffrey S. Ross, Marc Ladanyi, Samuel Singer, Murray F. Brennan, Gary K. Schwartz, Alexander J. Lazar, David M. Thomas, Robert G. Maki, William D. Tap, Siraj M. Ali, Dexter X. Jin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Comprehensive molecular profiles are required to understand and treat sarcomas, which comprise more than 70 different subtypes. Here, the authors profile the genomic landscape of 7494 sarcomas across 44 histologies using targeted panel sequencing and
Externí odkaz:
https://doaj.org/article/ded28dd2538e4114ba7de3e78b153f38
Autor:
Jain, Sparsh, Sankar, Ashwin, Choudhary, Devilal, Suman, Dhairya, Narasimhan, Nikhil, Khan, Mohammed Safi Ur Rahman, Kunchukuttan, Anoop, Khapra, Mitesh M, Dabre, Raj
Automatic Speech Translation (AST) datasets for Indian languages remain critically scarce, with public resources covering fewer than 10 of the 22 official languages. This scarcity has resulted in AST systems for Indian languages lagging far behind th
Externí odkaz:
http://arxiv.org/abs/2411.04699
Autor:
Prabhakar, Akshara, Li, Yuanzhi, Narasimhan, Karthik, Kakade, Sham, Malach, Eran, Jelassi, Samy
Low-Rank Adaptation (LoRA) is a popular technique for parameter-efficient fine-tuning of Large Language Models (LLMs). We study how different LoRA modules can be merged to achieve skill composition -- testing the performance of the merged model on a
Externí odkaz:
http://arxiv.org/abs/2410.13025
Autor:
Chattopadhyay, Sameep, Paliwal, Pulkit, Narasimhan, Sai Shankar, Agarwal, Shubhankar, Chinchali, Sandeep P.
Time series forecasts are often influenced by exogenous contextual features in addition to their corresponding history. For example, in financial settings, it is hard to accurately predict a stock price without considering public sentiments and polic
Externí odkaz:
http://arxiv.org/abs/2410.12672
Autor:
Narasimhan, Sai Shankar, Agarwal, Shubhankar, Rout, Litu, Shakkottai, Sanjay, Chinchali, Sandeep P.
Generating realistic time series samples is crucial for stress-testing models and protecting user privacy by using synthetic data. In engineering and safety-critical applications, these samples must meet certain hard constraints that are domain-speci
Externí odkaz:
http://arxiv.org/abs/2410.12652
Autor:
Brooks, Creston, Haubold, Johannes, Cowen-Breen, Charlie, White, Jay, DeVaul, Desmond, Riemenschneider, Frederick, Narasimhan, Karthik, Graziosi, Barbara
As premodern texts are passed down over centuries, errors inevitably accrue. These errors can be challenging to identify, as some have survived undetected for so long precisely because they are so elusive. While prior work has evaluated error detecti
Externí odkaz:
http://arxiv.org/abs/2410.11071
Autor:
Chakraborty, Nilanjan, Kasthurirangan, Prahlad Narasimhan, Mitchell, Joseph S. B., Nguyen, Linh, Perk, Michael
Assume that a target is known to be present at an unknown point among a finite set of locations in the plane. We search for it using a mobile robot that has imperfect sensing capabilities. It takes time for the robot to move between locations and sea
Externí odkaz:
http://arxiv.org/abs/2410.06069