Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Narasimhan Gautam"'
Publikováno v:
ACS Synth Biol
Cleavage furrow formation during cytokinesis involves extensive membrane remodeling. In the absence of methods to exert dynamic control over these processes, it has been a challenge to examine the basis of this remodeling. Here we used a subcellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9e7b77b5d4e39cf12b502478c7c4420
https://doi.org/10.1021/acssynbio.9b00521
https://doi.org/10.1021/acssynbio.9b00521
Publikováno v:
J Cell Sci
Cell shape regulation is important, but the mechanisms that govern shape are not fully understood, in part due to limited experimental models in which cell shape changes and underlying molecular processes can be rapidly and non-invasively monitored i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dfb724d7375a69ba7fb2d94c91264f6
https://europepmc.org/articles/PMC8277139/
https://europepmc.org/articles/PMC8277139/
Autor:
Xenia, Meshik, Narasimhan, Gautam
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2268
GPCRs are responsible for activation of numerous downstream effectors. Live cell imaging of these effectors therefore provides a real-time readout of GPCR activity and allows for better understanding of temporal dynamics of GPCR-mediated signaling. O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cfbcf24133e5683de918bf03cfae7d11
https://pubmed.ncbi.nlm.nih.gov/34085271
https://pubmed.ncbi.nlm.nih.gov/34085271
Autor:
Xenia Meshik, Narasimhan Gautam
Publikováno v:
Methods in Molecular Biology ISBN: 9781071612200
GPCRs are responsible for activation of numerous downstream effectors. Live cell imaging of these effectors therefore provides a real-time readout of GPCR activity and allows for better understanding of temporal dynamics of GPCR-mediated signaling. O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35bb7e3e11388a92b6e1c55ffc9ab156
https://doi.org/10.1007/978-1-0716-1221-7_14
https://doi.org/10.1007/978-1-0716-1221-7_14
Autor:
Kyle E. Parker, Kasey S. Girven, Abigail J. Elerding, Sofia E. Shirley, Robert W. Gereau, Roger K. Sunahara, Alexis M. Vasquez, M. Christine Stander, Kelly K.L. Ma, Patrick R. O’Neill, Jun Nan Li, Tommaso Patriarchi, Vani Kalyanaraman, Narasimhan Gautam, Vijay K. Samineni, Sherri K. Vogt, Lin Tian, Judy J. Yoo, Michael R. Bruchas, Skylar M. Spangler, Bobbie J. Brown, Raaj Gowrishankar, Bryan A. Copits, Xenia Meshik
Publikováno v:
Neuron. 109:1791-1809.e11
Optical manipulations of genetically defined cell types have generated significant insights into the dynamics of neural circuits. While optogenetic activation has been relatively straightforward, rapid and reversible synaptic inhibition has proven mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8ddc3645198435aaeef220256a6eb37
https://doi.org/10.1016/j.neuron.2021.04.026
https://doi.org/10.1016/j.neuron.2021.04.026
Publikováno v:
Optogenetics and Optical Manipulation 2019.
Optogenetics allows for the study of signaling pathways during a variety of cellular processes. Here we use subcellular optogenetics to study the role of vesicular trafficking in cytokinesis. Optogenetically activating RhoA in the cell midline induce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf3f3e594f8eb6618190a025e6231e2c
https://doi.org/10.1117/12.2508792
https://doi.org/10.1117/12.2508792
Cells experience physical deformations to the plasma membrane that can modulate cell behaviors like migration. Understanding the molecular basis for how physical cues affect dynamic cellular responses requires new approaches that can physically pertu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f44cf6328cf07f052e9341d0e09bbba9
https://europepmc.org/articles/PMC7081452/
https://europepmc.org/articles/PMC7081452/
Publikováno v:
Methods in Molecular Biology ISBN: 9781493977000
Subcellular optogenetics allows specific proteins to be optically activated or inhibited at a restricted subcellular location in intact living cells. It provides unprecedented control of dynamic cell behaviors. Optically modulating the activity of si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf34bdf4bf3fd6d174cb044c7e7a0ac6
https://doi.org/10.1007/978-1-4939-7701-7_22
https://doi.org/10.1007/978-1-4939-7701-7_22
Autor:
Narasimhan Gautam, Patrick R. O’Neill
Publikováno v:
Photochemical & Photobiological Sciences. 14:1578-1585
Optogenetic tools have recently been developed that enable dynamic control over the activities of select signaling proteins. They provide the unique ability to rapidly turn signaling events on or off with subcellular control in living cells and organ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4965dc68e22c238ec212a1cc92251536
https://doi.org/10.1039/c5pp00171d
https://doi.org/10.1039/c5pp00171d
Autor:
Devin M. Barry, Shen Bin Liu, Narasimhan Gautam, Qing Tao Meng, Zhong Qiu Zhao, Ping Mo, Zhou-Feng Chen, Jie Zheng, W. K. Ajith Karunarathne, Admire Munanairi, Seung Il Kim, Li Wan, Shijin Yin, Wei Cheng, Kasun Ratnayake, Xian-Yu Liu
Publikováno v:
Science Signaling. 9
The transient receptor potential channels (TRPs) respond to chemical irritants and temperature. TRPV1 responds to the itch-inducing endogenous signal histamine, and TRPA1 responds to the itch-inducing chemical chloroquine. We showed that, in sensory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7f53621b1de5522c8eb82a4fd5142a0
https://doi.org/10.1126/scisignal.aaf1047
https://doi.org/10.1126/scisignal.aaf1047