Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Narasimha Rao, Krishnamurthy"'
Autor:
Takhi, Mohamed, Sreenivas, Kandepu, Reddy, Chandrashekar K., Munikumar, Mahadari, Praveena, Kolakota, Sudheer, Pabolu, Rao, Bandaru N.V.M., Ramakanth, Gollamudi, Sivaranjani, Jampala, Mulik, Shardaprasad, Reddy, Yeruva R., Narasimha Rao, Krishnamurthy, Pallavi, Rentala, Lakshminarasimhan, Anirudha, Panigrahi, Sunil K., Antony, Thomas, Abdullah, Iskandar, Lee, Yean K., Ramachandra, Murali, Yusof, Rohana, Rahman, Noorsaadah A., Subramanya, Hosahalli
Publikováno v:
In European Journal of Medicinal Chemistry 12 September 2014 84:382-394
Autor:
Manoj Pothuganti, Suraj T Gore, Narasimha Rao Krishnamurthy, Sunil Shivaji More, Sumalatha Rani Talapati, Thomas Antony, Murali Ramachandra, Vijayashankar Nataraj
Publikováno v:
Acta Crystallogr F Struct Biol Commun
CVT-313 is a potent CDK2 inhibitor that was identified by screening a purine-analogue library and is currently in preclinical studies. Since this molecule has the potential to be developed as a CDK2 inhibitor for cancer therapy, the potency of CVT-31
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6858cfcf63b5d46162b270a5fb6d94c9
https://europepmc.org/articles/PMC7397463/
https://europepmc.org/articles/PMC7397463/
Autor:
Bharat Lagu, Eric L. Bell, Effie Tozzo, Nirbhay Kumar Tiwari, Andrew Basinski, Arthur F. Kluge, Matthew M. Goddeeris, Ramesh S. Senaiar, Narasimha Rao Krishnamurthy, Ross Fredenburg, Sunil Kumar Panigrahi, Michael A. Patane, Mahaboobi Jaleel, Taisuke Takahashi, Peter Dwyer
Publikováno v:
ACS Medicinal Chemistry Letters. 9:935-940
The X-ray structure of the previously reported PPARδ modulator 1 bound to the ligand binding domain (LBD) revealed that the amide moiety in 1 exists in the thermodynamically disfavored cis-amide orientation. Isosteric replacement of the cis-amide wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0663921ac4e0f062d40544f2aece30db
https://doi.org/10.1021/acsmedchemlett.8b00287
https://doi.org/10.1021/acsmedchemlett.8b00287
Autor:
Lakshmi Narayan Kaza, Thomas Anthony, Sunil Kumar Pnaigrahi, Aditya Kiran Gatta, Kiran Aithal, Pravin Pise, Vijay Kamal Ahuja, Narasimha Rao Krishnamurthy, Sanjeev Giri, Vinayak Khairnar, Narasimha Raju Kalidindi, Murali Ramachandra, KB Charamannna, Nirbhay Kumar Tiwari, Susanta Samajdar, Vijaya Shankar Nataraj, Dinesh Chikkanna, Shekar Chelur, Kavitha Nellore, Manoj Pothuganti, Sandeep Patil, DS Samiulla, Leena Khare Satyam
Publikováno v:
Cancer Research. 81:1266-1266
Dysregulated fatty acid metabolism is thought to be a hallmark of cancer, wherein fatty acids function both as an energy source and as signals for enzymatic and transcriptional networks contributing to malignancy. Fatty acid-binding protein 5 (FABP5)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0cc315b02b322125cd0c1358d889a71
https://doi.org/10.1158/1538-7445.am2021-1266
https://doi.org/10.1158/1538-7445.am2021-1266
Autor:
Mahaboobi Jaleel, Matthew M. Goddeeris, Ramesh S. Senaiar, Peter Dwyer, Eric L. Bell, Sunil Kumar Panigrahi, Ross Fredenburg, Bharat Lagu, Narasimha Rao Krishnamurthy, Andrew Basinski, Michael A. Patane, Nirbhay Kumar Tiwari, Taisuke Takahashi, Effie Tozzo, Arthur F. Kluge
[Image: see text] The X-ray structure of the previously reported PPARδ modulator 1 bound to the ligand binding domain (LBD) revealed that the amide moiety in 1 exists in the thermodynamically disfavored cis-amide orientation. Isosteric replacement o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6579f783424d3bdf0cdce8fc284c2809
https://europepmc.org/articles/PMC6580794/
https://europepmc.org/articles/PMC6580794/
Autor:
Karthikeyan Narasingapuram Arumugam, Jwala Nagaraj, DS Samiulla, Murali Ramachandra, Rajendra K. Palakurthy, Rajeev Goswami, Olli Törmäkangas, Anirudha Lakshminarasimhan, Narasimha Rao Krishnamurthy, Gerd Wohlfahrt, Anu Moilanen, Subhendu Mukherjee, Mahaboobi Jaleel, Anita R. Chacko
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:5309-5314
Hepsin, a type II transmembrane serine protease, is upregulated in prostate cancer and known to be involved in the progression of metastasis. Here we report a structure-guided approach, which resulted in the discovery of 2-aryl/pyridin-2-yl-1H-indole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e11309c3bb66ab52d9329fa0c0ba4c60
https://doi.org/10.1016/j.bmcl.2015.09.042
https://doi.org/10.1016/j.bmcl.2015.09.042
Autor:
Rajeev Goswami, Subhendu Mukherjee, Gerd Wohlfahrt, Jwala Nagaraj, Krishnaprasad Subbarao, Chakshusmathi Ghadiyaram, Narasimha Rao Krishnamurthy, Leena Khare Satyam, Sreevalsam Gopinath, Hosahalli Subramanya, Murali Ramachandra
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:616-620
Matriptase is a cell-surface trypsin-like serine protease of epithelial origin, which cleaves and activates proteins including hepatocyte growth factor/scatter factor and proteases such as uPA, which are involved in the progression of various cancers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af98eb705b94b9713c1a02f4738d18fb
https://doi.org/10.1016/j.bmcl.2014.12.008
https://doi.org/10.1016/j.bmcl.2014.12.008
Autor:
Sunil Kumar Panigrahi, Effie Tozzo, Narasimha Rao Krishnamurthy, Taisuke Takahashi, Mahaboobi Jaleel, Nirbhay Kumar Tiwari, Bharat Lagu, Michael A. Patane, Ramesh S. Senaiar, Ross Fredenburg, Arthur F. Kluge
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(23)
Optimization of benzamide PPARδ modulator 1 led to (E)-6-(2-((4-(furan-2-yl)-N-methylbenzamido)methyl)phenoxy)-4-methylhex-4-enoic acid (18), a potent selective PPARδ modulator with significantly improved exposure in multiple species following oral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f57037ac6e56607083a4697cf927ed4
https://pubmed.ncbi.nlm.nih.gov/29103972
https://pubmed.ncbi.nlm.nih.gov/29103972
Autor:
Kumari Mahasweta, Manoj Rajappa, Sangeetha Raghuramachandran, Mohammadjavad Paydar, Anirudha Lakshminarasimhan, Sujatha Rajagopalan, Anuradha Ramanathan, Murali Ramachandra, Subramanya Hosahalli, Venkateshwar Rao Gummadi, Sunil Kumar Panigrahi, Bharathi Raja Ainan, Narasimha Rao Krishnamurthy, Srinivas Nanduri, Mohammad Rais Mustafa, Pooi-Fong Wong, Chung Yeng Looi, Girish Aggunda Renukappa
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:4911-4918
We have identified a novel 7-azaindole series of anaplastic lymphoma kinase (ALK) inhibitors. Compounds 7b, 7 m and 7 n demonstrate excellent potencies in biochemical and cellular assays. X-ray crystal structure of one of the compounds (7 k) revealed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1661e6f48afd066e936eb2b3e55a3381
https://doi.org/10.1016/j.bmcl.2013.06.071
https://doi.org/10.1016/j.bmcl.2013.06.071
Autor:
Narasimha Rao, Krishnamurthy, Lakshminarasimhan, Anirudha, Joseph, Sarah, Lekshmi, Swathi U, Lau, Ming-Seong, Takhi, Mohammed, Sreenivas, Kandepu, Nathan, Sheila, Yusof, Rohana, Abd Rahman, Noorsaadah, Ramachandra, Murali, Antony, Thomas, Subramanya, Hosahalli
Melioidosis is a tropical bacterial infection caused by Burkholderia pseudomallei (B. pseudomallei; Bpm), a Gram-negative bacterium. Current therapeutic options are largely limited to trimethoprim-sulfamethoxazole and β-lactam drugs, and the treatme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2355d916ca6b9412bbd5081ea5b579c4
https://europepmc.org/articles/PMC4420531/
https://europepmc.org/articles/PMC4420531/