Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Narasimha M. Midde"'
Autor:
Yuqing Gong, Pallabita Chowdhury, Narasimha M. Midde, Mohammad A. Rahman, Murali M. Yallapu, Santosh Kumar
Publikováno v:
Biochemistry and Biophysics Reports, Vol 12, Iss C, Pp 214-219 (2017)
Purpose: Monocytes serve as sanctuary sites for HIV-1 from which virus is difficult to be eliminated. Therefore, an effective viral suppression in monocytes is critical for effective antiretroviral therapy (ART). This study focuses on a new strategy
Externí odkaz:
https://doaj.org/article/7dd7733deeb64b64a39a9add8d800ef3
Autor:
Narasimha M Midde, Mohammad A Rahman, Chetan Rathi, Junhao Li, Bernd Meibohm, Weihua Li, Santosh Kumar
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0149225 (2016)
Elvitegravir (EVG), an integrase inhibitor for the treatment HIV infection, is increasingly becoming the part of first-line antiretroviral therapy (ART) regimen. EVG is mainly metabolized through cytochrome P450 (CYP) 3A4. Previously, we have shown t
Externí odkaz:
https://doaj.org/article/f45591a32d0849008998d363b5ec4645
Autor:
Sabina Ranjit, Narasimha M Midde, Namita Sinha, Benjamin J Patters, Mohammad A Rahman, Theodore J Cory, P S S Rao, Santosh Kumar
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0163827 (2016)
BACKGROUND:Benzo(a)pyrene (BaP), naphthalene (NPh), phenanthrene (Phe), benzo(a)antharacene (BeA), and benzo(b)fluoranthene (BeF) are known carcinogenic polyaryl hydrocarbons (PAHs) present in cigarette smoke. This study was designed to examine the r
Externí odkaz:
https://doaj.org/article/7316863366a54653ae5df3173134faec
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e44149 (2012)
Exposure within an environmental enrichment paradigm results in neurobiological adaptations and decreases the baseline of locomotor activity. The current study determined activation of DARPP-32 (dopamine- and cAMP-regulated phosphoprotein-32) and CRE
Externí odkaz:
https://doaj.org/article/a492eef80d24471b8ec332e87b7e196f
Publikováno v:
Current HIV Research
Background: Cigarette smoking increases systemic oxidative stress, inflammation, and viral replication in individuals with HIV. Macrophages are infected during HIV infection and serve as an important reservoir throughout the process. Macrophages exis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b4cc5fd8d07ad7e5f42ea09fc67cf65
http://europepmc.org/articles/PMC6446460
http://europepmc.org/articles/PMC6446460
Autor:
Murali M. Yallapu, Pallabita Chowdhury, Narasimha M. Midde, Santosh Kumar, Mohammad A. Rahman, Yuqing Gong
Publikováno v:
Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports, Vol 12, Iss C, Pp 214-219 (2017)
Biochemistry and Biophysics Reports, Vol 12, Iss C, Pp 214-219 (2017)
Purpose Monocytes serve as sanctuary sites for HIV-1 from which virus is difficult to be eliminated. Therefore, an effective viral suppression in monocytes is critical for effective antiretroviral therapy (ART). This study focuses on a new strategy u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33396be2a94bae75517f746b51ee1b93
https://doi.org/10.1016/j.bbrep.2017.10.005
https://doi.org/10.1016/j.bbrep.2017.10.005
Autor:
Sabina Ranjit, Sanjana Haque, Fatah Kashanchi, Namita Sinha, Narasimha M. Midde, Santosh Kumar
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Scientific Reports
Scientific Reports
Smoking is known to exacerbate HIV-1 pathogenesis, especially in monocytes, through the oxidative stress pathway. Exosomes are known to alter HIV-1 pathogenesis through inter-cellular communication. However, the role of exosomes in smoking-mediated H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcf822963b603a92ec1567805dea9c86
http://link.springer.com/article/10.1038/s41598-017-16301-9
http://link.springer.com/article/10.1038/s41598-017-16301-9
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:5573-5579
Using molecular modeling and rationally designed structural modifications, the multi-target structure–activity relationship for a series of ranitidine analogs has been investigated. Incorporation of a variety of isosteric groups indicated that appr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f3d03cba187de18f7e3315dacc37f6f
https://doi.org/10.1016/j.bmcl.2016.09.072
https://doi.org/10.1016/j.bmcl.2016.09.072
Publikováno v:
Expert Opinion on Investigational Drugs. 25:1189-1200
Highly Active Antiretroviral Therapy (HAART) has tremendously improved the life expectancy of the HIV-infected population over the past three decades. Protease inhibitors have been one of the major classes of drugs in HAART regimens that are effectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33624315bd3ddff7f0efa0a50de113b4
https://doi.org/10.1080/13543784.2016.1212837
https://doi.org/10.1080/13543784.2016.1212837
Autor:
Wei-Lun Sun, Chang-Guo Zhan, Adrian M. Gomez, Yaxia Yuan, Pamela M. Quizon, Narasimha M. Midde, Jun Zhu
Publikováno v:
Journal of NeuroVirology. 22:282-292
HIV viral proteins within the central nervous system are associated with the development of neurocognitive impairments in HIV-infected individuals. Dopamine transporter (DAT)-mediated dopamine transport is critical for normal dopamine homeostasis. Ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b54889320d92079e46eaf3b73e15b6a9
https://doi.org/10.1007/s13365-015-0391-6
https://doi.org/10.1007/s13365-015-0391-6