Zobrazeno 1 - 10 of 203 pro vyhledávání: '"Narain D. Sharma"'
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Akademický článek
Toluene Dioxygenase-Catalyzed cis-Dihydroxylation of Quinolines: A Molecular Docking Study and Chemoenzymatic Synthesis of Quinoline Arene Oxides
Autor: Derek R. Boyd, Narain D. Sharma, Pui L. Loke, Jonathan G. Carroll, Paul J. Stevenson, Patrick Hoering, Christopher C. R. Allen
Publikováno v: Frontiers in Bioengineering and Biotechnology, Vol 8 (2021)
Molecular docking studies of quinoline and 2-chloroquinoline substrates at the active site of toluene dioxygenase (TDO), were conducted using Autodock Vina, to identify novel edge-to-face interactions and to rationalize the observed stereoselective c
Externí odkaz: https://doaj.org/article/b3a14fd3cfda44f0bb47e8ad3393a055
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2
Monooxygenase- and Dioxygenase-Catalyzed Oxidative Dearomatization of Thiophenes by Sulfoxidation, cis-Dihydroxylation and Epoxidation
Autor: Derek R. Boyd, Narain D. Sharma, Paul J. Stevenson, Patrick Hoering, Christopher C. R. Allen, Patrick M. Dansette
Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 909, p 909 (2022)
Boyd, D R, Sharma, N D, Stevenson, P J, Hoering, P, Allen, C C R & Dansette, P M 2022, ' Monooxygenase-and Dioxygenase-Catalyzed Oxidative Dearomatization of Thiophenes by Sulfoxidation, cis-Dihydroxylation and Epoxidation ', International Journal of Molecular Sciences, vol. 23, no. 2, 909 . https://doi.org/10.3390/ijms23020909
International Journal of Molecular Sciences
Enzymatic oxidations of thiophenes, including thiophene-containing drugs, are important for biodesulfurization of crude oil and drug metabolism of mono- and poly-cyclic thiophenes. Thiophene oxidative dearomatization pathways involve reactive metabol
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b74d240ecc404009631677744c2e8ec1
https://www.mdpi.com/1422-0067/23/2/909
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4
Chemoenzymatic Synthesis of (−)-Ribisins A and B from Dibenzo[b,d]furan
Autor: Derek R. Boyd, Christopher J. McGivern, Christopher C. R. Allen, Patrick Hoering, Narain D. Sharma, Paul J. Stevenson
Publikováno v: Boyd, D R, Sharma, N D, McGivern, C J, Stevenson, P J, Hoering, P & Allen, C C R 2019, ' Chemoenzymatic Synthesis of (-)-Ribisins A and B from Dibenzo[b,d]furan ', Journal of Organic Chemistry, vol. 84, pp. 15165-15172 . https://doi.org/10.1021/acs.joc.9b02171
cis-Dihydrodiols, derived from monocyclic aromatic compounds, are valuable chiral pool intermediates for the synthesis of cyclic natural products. A drawback of this approach, to the synthesis of polycyclic secondary metabolites, is that additional r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::116e5cf34ba923309944116d98b55157
https://doi.org/10.1021/acs.joc.9b02171
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5
Toluene Dioxygenase-Catalyzed cis-Dihydroxylation of Quinolines: A Molecular Docking Study and Chemoenzymatic Synthesis of Quinoline Arene Oxides
Autor: Patrick Hoering, Jonathan G. Carroll, Derek R. Boyd, Paul J. Stevenson, Pui L. Loke, Christopher C. R. Allen, Narain D. Sharma
Publikováno v: Frontiers in Bioengineering and Biotechnology, Vol 8 (2021)
Boyd, D, Das Sharma, N, Loke, P L, Carroll, J G, Stevenson, P, Hoering, P & Allen, C C R 2021, ' Toluene Dioxygenase-Catalyzed cis-Dihydroxylation of Quinolines: A Molecular Docking Study and Chemoenzymatic Synthesis of Quinoline Arene Oxides ', Frontiers in Bioengineering and Biotechnology . https://doi.org/10.3389/fbioe.2020.619175
Molecular docking studies of quinoline and 2-chloroquinoline substrates at the active site of toluene dioxygenase (TDO), were conducted using Autodock Vina, to identify novel edge-to-face interactions and to rationalize the observed stereoselective c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a273fdf47f1c25f585df9063d9068dd
https://www.frontiersin.org/articles/10.3389/fbioe.2020.619175/full
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7
cis‐Dihydroxylation of Tricyclic Arenes and Heteroarenes Catalyzed by Toluene Dioxygenase: A Molecular Docking Study and Experimental Validation
Autor: Christopher J. McGivern, Christopher C. R. Allen, Ian N. Brannigan, Derek R. Boyd, Narain D. Sharma, Colin McRoberts, Peter Nockemann, Patrick Hoering, Paul J. Stevenson
Publikováno v: Boyd, D, Sharma, N D, Brannigan, I, McGivern, C, Nockemann, P, Stevenson, P, McRoberts, C, Hoering, P & Allen, C C R 2019, ' cis-Dihydroxylation of Tricyclic Arenes and Heteroarenes Catalyzed by Toluene Dioxygenase: A Molecular Docking Study and Experimental Validation ', Advanced Synthesis & Catalysis . https://doi.org/10.1002/adsc.201900147
Molecular docking studies of toluene dioxygenase (TDO) led to the prediction that angular and lateral cis‐dihydroxylation of tricyclic arene and heteroarene substrates could occur. Biotransformations of biphenylene, dibenzofuran, carbazole and dibe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb12ef426b292992c8055c73cf641007
https://pure.qub.ac.uk/en/publications/cisdihydroxylation-of-tricyclic-arenes-and-heteroarenes-catalyzed-by-toluene-dioxygenase-a-molecular-docking-study-and-experimental-validation(50853b4a-7862-402a-80bc-d5045176e60a).html
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8
Chemoenzymatic synthesis of enantiopure hydroxy sulfoxides derived from substituted arenes
Autor: John F. Malone, Steven D. Shepherd, Derek R. Boyd, Christopher C. R. Allen, Deirdre Murphy, Vera Ljubez, Narain D. Sharma
Publikováno v: Organic & Biomolecular Chemistry. 14:2651-2664
Enantiopure β-hydroxy sulfoxides and catechol sulfoxides were obtained, by chemoenzymatic synthesis, involving dioxygenase-catalysed benzylic hydroxylation or arene cis-dihydroxylation and cis-diol dehydrogenase-catalysed dehydrogenation. Absolute c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71c390cb41dc16af9734b78f9eafa183
https://doi.org/10.1039/c5ob02411k
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9
Arenecis-Diol Dehydrogenase-Catalysed Regio- and Stereoselective Oxidation of Arene-, Cycloalkane- and Cycloalkene-cis-diols to Yield Catechols and Chiral α-Ketols
Autor: Gareth McConville, Derek R. Boyd, Paul J. Stevenson, Christopher Hardacre, Leonid A. Kulakov, M. Victoria Berberian, Christopher C. R. Allen, Narain D. Sharma, Vera Ljubez, Marcel C. Cleij
Publikováno v: Advanced Synthesis & Catalysis. 357:1881-1894
Benzene cis-diol dehydrogenase and naphthalene cis-diol dehydrogenase enzymes, expressed in Pseudomonas putida wild-type and Escherichia coli recombinant strains, were used to investigate regioselectivity and stereoselectivity during dehydrogenations
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::330ee74806b66586571d69c080b5317f
https://doi.org/10.1002/adsc.201500189
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10
Toluene Dioxygenase-Catalyzed Synthesis and Reactions of cis-Diol Metabolites Derived from 2- and 3-Methoxyphenols
Autor: Christopher C. R. Allen, Amit Gohil, Colin McRoberts, Peter B. A. McIntyre, Peter N. Horton, Paul J. Stevenson, John F. Malone, Narain D. Sharma, Simon J. Coles, Stewart Floyd, Derek R. Boyd
Publikováno v: ResearcherID
Using toluene dioxygenase as biocatalyst, enantiopure cis-dihydrodiol and cis-tetrahydrodiol metabolites, isolated as their ketone tautomers, were obtained from meta and ortho methoxyphenols. Although these isomeric phenol substrates are structurally
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfb4cda644f48ed1ab317d1be5408f31
https://doi.org/10.1021/jo5028968
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