Over-Expression of Hypochlorite Inducible Major Facilitator Superfamily (MFS) Pumps Reduces Antimicrobial Drug Susceptibility by Increasing the Production of MexXY Mediated by ArmZ in Pseudomonas aeruginosa

Autor: Punyawee Dulyayangkul, Naphat Satapoomin, Matthew B. Avison, Nisanart Charoenlap, Paiboon Vattanaviboon, Skorn Mongkolsuk

Publikováno v: Frontiers in Microbiology, Vol 11 (2021)

Pseudomonas aeruginosa, a well-known cause of nosocomial infection, is frequently antibiotic resistant and this complicates treatment. Links between oxidative stress responses inducing antibiotic resistance through over-production of RND-type efflux

Externí odkaz: https://doaj.org/article/a88cd7a9227e497992b2c3e7de91715b

OmpF Downregulation Mediated by Sigma E or OmpR Activation Confers Cefalexin Resistance in Escherichia coli in the Absence of Acquired β-Lactamases

Autor: Kate J. Heesom, Naphat Satapoomin, Maryam Alzayn, Punyawee Dulyayangkul, Matthew B. Avison

Publikováno v: Avison, M B, Dulyayangkul, P, Alzayn, M M A, Satapoomin, A & Heesom, K J 2021, ' OmpF Downregulation Mediated by Sigma E or OmpR Activation Confers Cefalexin Resistance in Escherichia coli in the Absence of Acquired β-Lactamases. ', Antimicrobial Agents and Chemotherapy, vol. 65, no. 11 . https://doi.org/10.1128/AAC.01004-21
Antimicrob Agents Chemother

Cefalexin is a widely used first-generation cephalosporin, and resistance in Escherichia coli is caused by extended-spectrum (e.g., CTX-M) and AmpC β-lactamase production and therefore frequently coincides with third-generation cephalosporin resista

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d439b8df41f69957bc86c22845ce6d70
https://doi.org/10.1128/aac.01004-21