Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Naoyuki Kotoku"'
Publikováno v:
Molecules, Vol 29, Iss 17, p 4058 (2024)
A novel and concise synthetic method for arenastatin A, a cytotoxic cyclic depsipeptide of marine origin, was developed in this study. The convergent assembly of the four segments, including the cross-metathesis reaction, gave a cyclization precursor
Externí odkaz:
https://doaj.org/article/bfa2bdacf0044f8987207c4e830c3e72
Publikováno v:
Molecules, Vol 29, Iss 6, p 1389 (2024)
Makaluvamine J, a pyrroloiminoquinone alkaloid of marine sponge origin, and its analogs were synthesized and assessed for their potential to develop as a novel and selective growth inhibitor targeting human pancreatic cancer PANC-1 cells. Ts-damirone
Externí odkaz:
https://doaj.org/article/d58e9ac208d54d97abc5b30539cc7b3b
Publikováno v:
Marine Drugs, Vol 21, Iss 5, p 311 (2023)
A shorter synthesis of the demethyl(oxy)aaptamine skeleton was developed via oxidative intramolecular cyclization of 1-(2-azidoethyl)-6-methoxyisoquinolin-7-ol followed by dehydrogenation with a hypervalent iodine reagent. This is the first example o
Externí odkaz:
https://doaj.org/article/de48a0f904374e7ca06dec301bb7bcc1
Autor:
Man Hagiyama, Takahiro Mimae, Akihiro Wada, Fuka Takeuchi, Azusa Yoneshige, Takao Inoue, Naoyuki Kotoku, Hironobu Hamada, Yoshitaka Sekido, Morihito Okada, Akihiko Ito
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Malignant pleural mesothelioma (MPM) is a highly aggressive malignant tumor, and the effective therapeutic drugs are limited. Thus, the establishment of novel therapeutic method is desired. Considerable proportion of MPMs are shown to express cell ad
Externí odkaz:
https://doaj.org/article/257be0bb6f184393914785936f0d9ed4
Publikováno v:
Molecules, Vol 27, Iss 24, p 8701 (2022)
The synthesis and evaluation of simplified analogs of marine sponge-derived alkaloid 3-(phenethylamino)demethyl(oxy)aaptamine were performed to develop novel anti-mycobacterial substances. Ring truncation of the tricyclic benzo[de][1,6]-naphthyridine
Externí odkaz:
https://doaj.org/article/6a7015302fb949fcb12279afa65ef0a3
Autor:
Yuji Sumii, Kentaro Kamiya, Takehiko Nakamura, Kenta Tanaka, Takumi Kaji, Junya Mukomura, Naoyuki Kotoku, Masayoshi Arai
Publikováno v:
Marine Drugs, Vol 20, Iss 2, p 98 (2022)
The current tuberculosis treatment regimen is long and complex, and its failure leads to relapse and emergence of drug resistance. One of the major reasons underlying the extended chemotherapeutic regimen is the ability of Mycobacterium tuberculosis
Externí odkaz:
https://doaj.org/article/4a00fe0bf4fa40088e321a4ac0270441
Autor:
Yuji Sumii, Naoyuki Kotoku, Akinori Fukuda, Takashi Kawachi, Masayoshi Arai, Motomasa Kobayashi
Publikováno v:
Marine Drugs, Vol 13, Iss 12, Pp 7419-7432 (2015)
Oral dictyoceratin-C (1) and A (2), hypoxia-selective growth inhibitors, showed potent in vivo antitumor effects in mice subcutaneously inoculated with sarcoma S180 cells. Structurally modified analogs were synthesized to assess the structure–activ
Externí odkaz:
https://doaj.org/article/f8242298903e409b80bf8067d59277cd
Autor:
Junya, Mukomura, Hiroki, Nonaka, Hiromasa, Sato, Maho, Kishimoto, Masayoshi, Arai, Naoyuki, Kotoku
Publikováno v:
Molecules (Basel, Switzerland). 27(24)
The synthesis and evaluation of simplified analogs of marine sponge-derived alkaloid 3-(phenethylamino)demethyl(oxy)aaptamine were performed to develop novel anti-mycobacterial substances. Ring truncation of the tricyclic benzo[
Autor:
Takashi Kawachi, Shun Tanaka, Akinori Fukuda, Yuji Sumii, Andi Setiawan, Naoyuki Kotoku, Motomasa Kobayashi, Masayoshi Arai
Publikováno v:
Marine Drugs, Vol 17, Iss 3, p 163 (2019)
Hypoxia-adapted cancer cells in tumors contribute to the pathological progression of cancer. The marine spongean sesquiterpene phenols dictyoceratin-A (1) and -C (2) have been shown to induce hypoxia-selective growth inhibition in cultured cancer cel
Externí odkaz:
https://doaj.org/article/0a4a25132b2d40dd8b57ba9d903c6c0d
Autor:
Yuji Sumii, Kentaro Kamiya, Takehiko Nakamura, Kenta Tanaka, Takumi Kaji, Junya Mukomura, Naoyuki Kotoku, Masayoshi Arai
Publikováno v:
Marine Drugs; Volume 20; Issue 2; Pages: 98
The current tuberculosis treatment regimen is long and complex, and its failure leads to relapse and emergence of drug resistance. One of the major reasons underlying the extended chemotherapeutic regimen is the ability of Mycobacterium tuberculosis