Zobrazeno 1 - 10
of 692
pro vyhledávání: '"Naoyuki, Kamatani"'
Publikováno v:
Journal of Physiological Sciences, Vol 73, Iss 1, Pp 1-9 (2023)
Abstract Duchenne muscular dystrophy (DMD) is an inherited disorder with mutations in the dystrophin gene characterized by progressive muscle degeneration and weakness. Therapy such as administration of glucocorticoids, exon skipping of mutant genes
Externí odkaz:
https://doaj.org/article/85742d7523a34a1fb086c190c2311779
Autor:
Masanari Kuwabara, Michikazu Nakai, Yoko Sumita, Yoshitaka Iwanaga, Ryusuke Ae, Takahide Kodama, Ichiro Hisatome, Naoyuki Kamatani
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2024)
Objectives: This study investigates the impact of xanthine oxidase inhibitors (XOI) on mortality in patients with cardiovascular diseases. XOI withdrawal has been reported to increased mortality risk due to rapid adenosine triphosphate (ATP) deficien
Externí odkaz:
https://doaj.org/article/5082f3bef46c48a2a0e2c657d8119aed
Publikováno v:
Journal of Physiological Sciences, Vol 72, Iss 1, Pp 1-15 (2022)
Abstract Aging is the deterioration of physiological mechanisms that is associated with getting old. There is a link between aging and mitochondrial function. However, there is an unresolved relationship between ATP levels and aging. To address this
Externí odkaz:
https://doaj.org/article/7d50419f8b9f4a5ea6219784e5dd8336
Autor:
Hisashi Yamanaka, Naoyuki Kamatani, Yoshiya Tanaka, Toshihiko Hibino, Edit Drescher, Juan Sánchez-Bursón, Manfred Rettenbacher, Girish Bhatia, Snehal Gadve, Chirag Shah, Dhananjay Bakhle
Publikováno v:
Rheumatology and Therapy, Vol 7, Iss 1, Pp 149-163 (2019)
Abstract Introduction YLB113 is a biosimilar of the reference product (RP), etanercept, under development for treatment of patients with moderate-to-severe rheumatoid arthritis (RA) and other approved indications. A phase 3 study was conducted in Eur
Externí odkaz:
https://doaj.org/article/bfca5c3d52374b569bb7711dacc74cc9
Autor:
Makoto, Kurano, Kazuhisa, Tsukamoto, Shigeo, Kamitsuji, Naoyuki, Kamatani, Koji, Hasegawa, Masumi, Hara, Toshio, Ishikawa, Yutaka, Yatomi, Tamio, Teramoto
Publikováno v:
Inflammation Research. 72:263-280
HDL has been proposed to possess anti-inflammatory properties; however, the detail mechanisms have not been fully elucidated.We investigated the roles of Apolipoprotein D (ApoD) in the pathogenesis of inflammation in the mouse model of diet-induced o
Autor:
Tetsuya Hirata, Kaori Koga, Todd A. Johnson, Ryoko Morino, Kazuyuki Nakazono, Shigeo Kamitsuji, Masanori Akita, Maiko Kawajiri, Azusa Kami, Yuria Hoshi, Asami Tada, Kenichi Ishikawa, Maaya Hine, Miki Kobayashi, Nami Kurume, Tomoyuki Fujii, Naoyuki Kamatani, Yutaka Osuga
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-17 (2018)
Abstract Traits related to primary and secondary sexual characteristics greatly impact females during puberty and day-to-day adult life. Therefore, we performed a GWAS analysis of 11,348 Japanese female volunteers and 22 gynecology-related phenotypic
Externí odkaz:
https://doaj.org/article/d10006041d124978a8403f2f3a20618a
Autor:
Takashi Kido, Weronika Sikora-Wohlfeld, Minae Kawashima, Shinichi Kikuchi, Naoyuki Kamatani, Anil Patwardhan, Richard Chen, Marina Sirota, Keiichi Kodama, Dexter Hadley, Atul J. Butte
Publikováno v:
BMC Medical Genomics, Vol 11, Iss 1, Pp 1-11 (2018)
Abstract Background Genome-wide association studies (GWASs) have revealed relationships between over 57,000 genetic variants and diseases. However, unlike Mendelian diseases, complex diseases arise from the interplay of multiple genetic and environme
Externí odkaz:
https://doaj.org/article/16d4a69f91764aed8a10ed5a6a8133ff
Autor:
Yohei Masunaga, Yasuko Fujisawa, Massart, Francesco, Spinelli, Claudio, Yoshiyuki Kojima, Kentaro Mizuno, Yutaro Hayashi, Isoji Sasagawa, Rie Yoshida, Fumiko Kato, Maki Fukami, Naoyuki Kamatani, Hirotomo Saitsu, Tsutomu Ogata
Publikováno v:
Journal of Clinical Endocrinology & Metabolism; Oct2023, Vol. 108 Issue 10, p2550-2560, 11p
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Germline mutations in cellular-energy associated genes have been shown to lead to various monogenic disorders. Notably, mitochondrial disorders often impact skeletal muscle, brain, liver, heart, and kidneys, which are the body’s top energy-consumin
Externí odkaz:
https://doaj.org/article/5a38c1d4f99f43d8b60ff187abb21f85
Publikováno v:
European Archives of Oto-Rhino-Laryngology. 279:4425-4433
Purpose We report the manufacture of particles containing a mixture of hydroxyapatite–argentum–titanium oxide (HAT), followed by attachment to nonwoven polyester fabrics to produce HAT-coated sheets (HATS) for use in masks. The purpose of the pre