Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Naoyoshi Yatsuzuka"'
Autor:
Keisuke Nakamura, Katsukuni Fujimoto, Chihiro Hasegawa, Ikuo Aoki, Hiroyuki Yoshitsugu, Hiroyuki Ugai, Naoyoshi Yatsuzuka, Yoshiyuki Tanaka, Kenichi Furihata, Brian M. Maas, Prachi K. Wickremasingha, Kelly E. Duncan, Marian Iwamoto, Selwyn A. Stoch, Naoto Uemura
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 11, Pp 2697-2708 (2022)
Abstract Molnupiravir (MK‐4482) is an oral prodrug of the antiviral ribonucleoside analog, N‐hydroxycytidine (NHC), which has activity against RNA viruses, including severe acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2). We conducted
Externí odkaz:
https://doaj.org/article/6adea459e92c4204accad4b1f01dc2eb
Autor:
Toshihiko Doi, Takashi Ogata, Shirong Han, Tomoko Takami, Toshikazu Moriwaki, Ken Kato, Fumio Nagashima, Naoyoshi Yatsuzuka, Ryu Ishihara, Pooja Bhagia, Kei Muro, Takashi Kojima, Keiichi Iwakami, Taroh Satoh, Hisato Kawakami
Publikováno v:
Esophagus
Background Safe and effective treatments for advanced esophageal cancer are an unmet need in Japan. We report results of a subgroup analysis of Japanese patients enrolled in KEYNOTE-181, a randomized, open-label, phase 3 study of pembrolizumab versus
Autor:
Kan Yonemori, Lance Leopold, Noboru Yamamoto, A. Samkari, Yutaka Fujiwara, Mihaela Munteanu, Takahiro Kogawa, Toshio Shimizu, Toshihiko Doi, Nobuaki Matsubara, Shi Rong Han, Izumi Ohno, Kohei Shitara, Yoichi Naito, Naoyoshi Yatsuzuka
Publikováno v:
Investigational New Drugs. 39:152-162
Part A of the open-label, phase I KEYNOTE-434 study evaluated the safety and tolerability of epacadostat, an indoleamine 2,3-dioxygenase-1 inhibitor, alone and in combination with pembrolizumab in Japanese patients with advanced solid tumors. Japanes
Autor:
Takashi Kojima, Hiroki Hara, Akihito Tsuji, Hisateru Yasui, Kei Muro, Taroh Satoh, Takashi Ogata, Ryu Ishihara, Masahiro Goto, Hideo Baba, Tomohiro Nishina, Shirong Han, Tomoko Sakata, Naoyoshi Yatsuzuka, Toshihiko Doi, Ken Kato
Publikováno v:
Esophagus : official journal of the Japan Esophageal Society. 19(4)
Background The phase 3 KEYNOTE-590 (NCT03189719) study showed first-line pembrolizumab plus chemotherapy significantly prolonged overall survival and progression-free survival versus placebo plus chemotherapy in patients with advanced unresectable or
Autor:
Shintaro Takaki, Yoshiyuki Suzuki, Yoshiyasu Karino, Takashi Iwasa, Luzelena Caro, Norifumi Kawada, Go Fujimoto, Etsuo Yodoya, Takeshi Okanoue, Janice Wahl, Naoyoshi Yatsuzuka, Kazuaki Chayama, Stuart Black, Yoshito Itoh, Hiromitsu Kumada, Hitoshi Yoshiji, Satoshi Mochida, Michael N. Robertson, Hidenori Toyoda
Publikováno v:
Journal of Gastroenterology
Background Elbasvir (EBR) in combination with grazoprevir (GZR) has demonstrated efficacy in patients with hepatitis C virus (HCV) infections in trials primarily conducted in the USA and Europe. We investigated the safety and efficacy of EBR in combi
Autor:
Takashi Shimamoto, Kahori Sasahara, Nobuaki Matsubara, Yoichi Naito, Naoyoshi Yatsuzuka, Noboru Yamamoto, Izumi Ohno, Toshio Shimizu, Yutaka Fujiwara, Kan Yonemori, Lance Leopold, Toshihiko Doi, Tomoko Takami, Kohei Shitara, Takahiro Kogawa
Publikováno v:
Molecular Cancer Therapeutics. 17:A204-A204
Background: INCB024360 (epacadostat) is an oral, potent, selective inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), a tryptophan-catabolizing enzyme that induces immune tolerance by T-cell suppression. Preliminary results from the phase I study of
Autor:
Naoyoshi Yatsuzuka, Emi Takeichi, Taisei Ueda, Kumiko Okada, Jinsaku Sakakibara, Hiromi Segi, Shin-ichi Nagai
Publikováno v:
Journal of Heterocyclic Chemistry. 38:141-145
Oxidation of 7,8-diaminotheophylline (1) with lead tetraacetate in refluxing toluene gave a mixture of 3-amino-5,7-dimethylpyrimido[4,5-e][1,2,4]triazine-6,8-dione (2) and 6-cyanoimino-5-diazo-1,3-dimethylpyrimidine-2,4-dione (4). The latter was tran
Autor:
Shin-ichi Nagai, Naoyoshi Yatsuzuka, Kumiko Okada, Emi Takeichi, Taisei Ueda, Jinsaku Sakakibara, Hiromi Segi
Publikováno v:
ChemInform. 32
Oxidation of 7,8-diaminotheophylline (1) with lead tetraacetate in refluxing toluene gave a mixture of 3-amino-5,7-dimethylpyrimido[4,5-e][1,2,4]triazine-6,8-dione (2) and 6-cyanoimino-5-diazo-1,3-dimethylpyrimidine-2,4-dione (4). The latter was tran