Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Naoyoshi Noguchi"'
Autor:
Ryo Ito, Yoshitomi Yayoi, Koji Watanabe, Teruki Hamada, Yasuhiro Hirata, Yasufumi Miyamoto, Seiji Miwatashi, Nobuyuki Takakura, Kazuaki Takami, Yoshihiko Hirozane, Naoyoshi Noguchi, Yusuke Moritoh, Mitsugi Ookawara, Hideki Furukawa, Jumpei Aida, Masanori Watanabe, Hitomi Yuko, Tsuyoshi Maekawa
Publikováno v:
Journal of Medicinal Chemistry. 63:10352-10379
GPR40/FFAR1 is a G-protein-coupled receptor expressed in pancreatic β-cells and enteroendocrine cells. GPR40 activation stimulates secretions of insulin and incretin, both of which are the pivotal regulators of glycemic control. Therefore, a GPR40 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19e7fd236db873a26ad100c00b8640fa
https://doi.org/10.1021/acs.jmedchem.0c00843
https://doi.org/10.1021/acs.jmedchem.0c00843
Autor:
Yoshiyuki Tsujihata, Hirohisa Miyashita, Kae Matsuda, Masahiro Kamaura, Shin-ichi Abe, Kenjiro Sato, Tomoyuki Odani, Osamu Kubo, Hiromichi Sugimoto, Toshiki Murata, Shinji Iwasaki, Naoyoshi Noguchi
Publikováno v:
Bioorganicmedicinal chemistry. 34
We previously identified a novel series of indolinylpyrimidine derivatives exemplified by 2 in Figure 1, which is an indoline based derivative, as potent GPR119 agonists. Despite the attractive potency of 2, this compound inhibited the human ether-a-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::166ee25c74829d63bf2f8da183f611d5
https://pubmed.ncbi.nlm.nih.gov/33548803
https://pubmed.ncbi.nlm.nih.gov/33548803
Autor:
Hideki, Furukawa, Yasufumi, Miyamoto, Yasuhiro, Hirata, Koji, Watanabe, Yuko, Hitomi, Yayoi, Yoshitomi, Jumpei, Aida, Naoyoshi, Noguchi, Nobuyuki, Takakura, Kazuaki, Takami, Seiji, Miwatashi, Yoshihiko, Hirozane, Teruki, Hamada, Ryo, Ito, Mitsugi, Ookawara, Yusuke, Moritoh, Masanori, Watanabe, Tsuyoshi, Maekawa
Publikováno v:
Journal of medicinal chemistry. 63(18)
GPR40/FFAR1 is a G-protein-coupled receptor expressed in pancreatic β-cells and enteroendocrine cells. GPR40 activation stimulates secretions of insulin and incretin, both of which are the pivotal regulators of glycemic control. Therefore, a GPR40 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cc19a5909e570e30b7f177db3ae7ad96
https://pubmed.ncbi.nlm.nih.gov/32900194
https://pubmed.ncbi.nlm.nih.gov/32900194
Autor:
Naoyoshi Noguchi, Lisa C. Standke, Asano Yasutomi, Derek S. Tan, Nihar Kinarivala, Tezcan Guney, Cheng Ji
Publikováno v:
Methods Enzymol
Salicyl-AMS (1) is a potent inhibitor of salicylate adenylation enzymes used in bacterial siderophore biosynthesis and a promising lead compound for the treatment of tuberculosis. An optimized, multigram synthesis is presented, which provides salicyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::971f7c61c6363b8d6030b9008d470889
https://europepmc.org/articles/PMC7367610/
https://europepmc.org/articles/PMC7367610/
Autor:
Stacia Kargman, Andrew John Jennings, Michael Miller, Andrew Stamford, Damodharan Lakshminarasimhan, Lewis C. Cantley, Anita D. Robin, Mayako Michino, David J. Huggins, Jiayi Xu, Edouard Mullarky, Andrea Olland, Daisuke Tomita, Naoyoshi Noguchi, Guoan Zhang, Peter T. Meinke, Taojunfeng Su
Publikováno v:
Bioorg Med Chem Lett
Cancer cells reprogram their metabolism to support growth and to mitigate cellular stressors. The serine synthesis pathway has been identified as a metabolic pathway frequently altered in cancers and there has been considerable interest in developing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f16e67aacdf7a18e54b2d994c08873d
https://pubmed.ncbi.nlm.nih.gov/31327531
https://pubmed.ncbi.nlm.nih.gov/31327531
Autor:
Mitsuaki Imanishi, Shinichi Masada, Ikuo Miyahisa, Kimio Tohyama, Shuichi Takagahara, Tomohiro Andou, Tetsuji Kawamoto, Hiroki Nagase, Ryouta Hayashi, Jun Fujimoto, Rei Okamoto, Nobuyuki Matsunaga, Kazuki Kubo, Koichi Iida, Naoyoshi Noguchi, Yumiko Okano Tamura, Tsuyoshi Maekawa, Ryoma Hara, Junji Matsui
Publikováno v:
Journal of medicinal chemistry. 60(21)
The discovery and optimization of Δ-5 desaturase (D5D) inhibitors are described. Investigation of the 1,3-oxazolidin-2-one scaffold was inspired by a pharmacophore model constructed from the common features of several hit compounds, resulting in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2d5ba83c7f16226e7e0a3790fed7e31
https://pubmed.ncbi.nlm.nih.gov/29023121
https://pubmed.ncbi.nlm.nih.gov/29023121
Publikováno v:
Tetrahedron: Asymmetry. 24:357-361
The pig liver esterase (PLE)-catalyzed kinetic resolution of half-esters derived from prochiral diesters is described. Generally, the PLE-catalyzed enantioselective hydrolysis of prochiral diesters affords the corresponding half-esters in high yield,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34bd95f11df387372302336a239349b3
https://doi.org/10.1016/j.tetasy.2013.01.019
https://doi.org/10.1016/j.tetasy.2013.01.019
Publikováno v:
Chemistry - A European Journal. 19:5476-5486
The enantioselective total synthesis of (+)-ophiobolin A is described. This total synthesis features the construction of the spiro CD ring of (+)-ophiobolin A through a stereoselective intramolecular Hosomi-Sakurai cyclization reaction, the joining o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0009d01532376201a02fd9639ecfa8ab
https://doi.org/10.1002/chem.201204119
https://doi.org/10.1002/chem.201204119
Publikováno v:
Tetrahedron Letters. 52:7202-7205
Synthesis of medium-sized carbocyclic ketones via the intramolecular B-alkyl Liebeskind–Srogl coupling reaction is described. The sequence of hydroboration of ω-alkenyl thiol ester with 9-BBN and the Liebeskind–Srogl reaction results in the form
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be2c48d072765e56bd1beb715cf2363c
https://doi.org/10.1016/j.tetlet.2011.10.148
https://doi.org/10.1016/j.tetlet.2011.10.148
Publikováno v:
Tetrahedron: Asymmetry. 19:2304-2309
This paper describes the preparation of a new chiral building block containing a benzylic quaternary stereogenic center via the highly enantioselective PLE-mediated hydrolysis of dimethyl 2-(2-chloro-5-methoxyphenyl)-2-methylmalonate, as well as the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::159d0e583345b6be08354f08f907c563
https://doi.org/10.1016/j.tetasy.2008.09.021
https://doi.org/10.1016/j.tetasy.2008.09.021