Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Naoyo Sano"'
Publikováno v:
Journal of Gastroenterology and Hepatology. 20:1069-1074
Background and Aims: α-Naphthylisothiocyanate (ANIT) is known to cause cholestasis due to injury of the bile duct epithelial cells. The aim of the present study was to examine the effect of a single dose of ANIT on the biliary excretion of various c
Publikováno v:
Journal of Gastroenterology and Hepatology. 19:1016-1022
Background and Aim: Colchicine, an inhibitor of intracellular vesicular transport, has been reported to inhibit the biliary excretion of bile acids and organic anions, but the previous findings are controversial. In order to systematically evaluate t
Publikováno v:
Journal of Gastroenterology and Hepatology. 18:815-821
Background: Lipopolysaccharide is known to be a cause of cholestasis associated with sepsis. It has also recently been reported to down-regulate the basolateral and canalicular transporters. The aim of the present study was to examine simultaneously
Autor:
Im-Chul Shin, Ki-Wan Oh, Hiroyuki Tanaka, Jin-Tae Hong, Yutaka Terata, M. Zafer Gören, Naoyo Sano, Hiroyuki Watanabe, Hitoshi Hasegawa, Rezzan Aker, Daniel H. Sturn, Filiz Onat, H. Raci Yananlı, Yoshikatsu Chiba, Mamoru Miura, Christian J. Wiedermann, Christian Meierhofer, Arun K. Agrawal, Stefan Dunzendorfer, Yoshimasa Fujiwara, Nicole C. Kaneider, Bernard H. Shapiro, Hyoung-Chun Kim, Satoshi Kibira, Hiroto Miura, Helmut Allmeier, Angela Djanani, Jeffrey W. Swanson, Hajime Takikawa, Takashi Saito
Publikováno v:
Pharmacology. 68:217-220
Publikováno v:
Pharmacology. 68:177-182
Glucuronide and glutathione conjugates have been reported to be substrates of multidrug resistance protein 2 (Mrp2), whereas sulfates of nonbile acid organic anions have never been reported as substrates of Mrp2. To further examine the substrate spec
Autor:
Toshiki Onishi, Kou Nishikawa, Hajime Takikawa, Atsuko Toda, Makoto Hojo, Hiroyuki Tanaka, Tatsuyuki Marumo, Hideki Tachizawa, Naoyo Sano, Naoko Hanawa
Publikováno v:
Hepatology Research. 24:136-140
Down-regulation of multidrug resistance protein 2 (Mrp2), a major canalicular organic anion transporter, has been reported in various cholestatic models and in patients with cholestasis. In the present study, biliary excretion of taurolithocholate-su
Publikováno v:
Hepatology Research. 20:216-220
Temocapril is a prodrug of an angiotensin-converting enzyme inhibitor, temocaprilat, a substrate of multidrug resistance protein 2. Hepatocytes in zone 1 play a role in the uptake and biliary excretion of bile acids under physiological condition, and
Publikováno v:
Hepatology Research. 15:157-162
Biliary organic anion excretion is mediated by an ATP-dependent primary active transporter, canalicular multispecific organic anion transporter/multidrug resistance protein 2. On the other hand, a multiplicity of canalicular organic anion transporter
Publikováno v:
Journal of Gastroenterology and Hepatology. 13:186-191
Several excretory pathways for cholephilic compounds have been known. To examine the changes in excretory pathways in cholestasis induced by ethinyloestradiol, various bile acids, organic anions and organic cations were intravenously administered to
Publikováno v:
Digestive Diseases and Sciences. 43:188-192
Biliary excretion of lithocholate-3-sulfate and ursodeoxycholate 3,7-disulfate is markedly impaired in EHBR. In the present study, the effects of ursodeoxycholate 3,7-disulfate infusion on lithocholate-3-sulfate excretion were studied in EHBR and Spr