Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Naoya Takayama"'
Autor:
Kentaro Kosaka, Naoya Takayama, Sudip Kumar Paul, Maria Alejandra Kanashiro, Motohiko Oshima, Masaki Fukuyo, Bahityar Rahmutulla, Ikuko Tajiri, Michiaki Mukai, Yoshitaka Kubota, Shinsuke Akita, Nobutaka Furuyama, Atsushi Kaneda, Atsushi Iwama, Koji Eto, Nobuyuki Mitsukawa
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Background Platelet-rich plasma (PRP), which is prepared by concentrating platelets in autologous blood, shows efficacy in chronic skin wounds via multiple growth factors. However, it exhibits heterogeneity across patients, leading to unstab
Externí odkaz:
https://doaj.org/article/39c0ece38100428681a107924e92574f
Autor:
Takahito Arai, Yasuhiro Shiga, Michiaki Mukai, Naoya Takayama, Susumu Tashiro, Ikuko Tajiri, Kentaro Kosaka, Masashi Sato, Sou Nakamura, Haruki Okamoto, Seiji Kimura, Kazuhide Inage, Miyako Suzuki-Narita, Yawara Eguchi, Sumihisa Orita, Koji Eto, Seiji Ohtori
Publikováno v:
Regenerative Therapy, Vol 26, Iss , Pp 850-858 (2024)
Introduction: Platelet-rich plasma obtained by centrifuging peripheral blood can promote osteogenesis owing to its abundant growth factors but has drawbacks, including rapid growth factor loss and inconsistent effects depending on donor factors. To o
Externí odkaz:
https://doaj.org/article/9de9395c9657460aae1449c10d2616de
Autor:
Haruki Okamoto, Kosuke Fujio, Sou Nakamura, Yasuo Harada, Hideki Hayashi, Natsumi Higashi, Atsushi Ninomiya, Ryota Tanaka, Naoshi Sugimoto, Naoya Takayama, Atsushi Kaneda, Akira Sawaguchi, Yoshikazu Kato, Koji Eto
Publikováno v:
Communications Engineering, Vol 3, Iss 1, Pp 1-12 (2024)
Abstract To complement donor-dependent platelets supplies, we previously developed an ex vivo manufacturing system using induced pluripotent stem cell (iPSC)-derived expandable immortalized megakaryocyte progenitor cell lines (imMKCLs), and a turbule
Externí odkaz:
https://doaj.org/article/63fcf19140a243b786caa7c95234af29
Autor:
Sudip Kumar Paul, Motohiko Oshima, Ashwini Patil, Masamitsu Sone, Hisaya Kato, Yoshiro Maezawa, Hiyori Kaneko, Masaki Fukuyo, Bahityar Rahmutulla, Yasuo Ouchi, Kyoko Tsujimura, Mahito Nakanishi, Atsushi Kaneda, Atsushi Iwama, Koutaro Yokote, Koji Eto, Naoya Takayama
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract The underlying mechanisms of atherosclerosis, the second leading cause of death among Werner syndrome (WS) patients, are not fully understood. Here, we establish an in vitro co-culture system using macrophages (iMφs), vascular endothelial c
Externí odkaz:
https://doaj.org/article/4b3e5780bad44b1cb65ac33d2b450617
Autor:
Si Jing Chen, Kazuya Hashimoto, Kosuke Fujio, Karin Hayashi, Sudip Kumar Paul, Akinori Yuzuriha, Wei-Yin Qiu, Emiri Nakamura, Maria Alejandra Kanashiro, Mio Kabata, Sou Nakamura, Naoshi Sugimoto, Atsushi Kaneda, Takuya Yamamoto, Hirohide Saito, Naoya Takayama, Koji Eto
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract We recently achieved the first-in-human transfusion of induced pluripotent stem cell-derived platelets (iPSC-PLTs) as an alternative to standard transfusions, which are dependent on donors and therefore variable in supply. However, heterogen
Externí odkaz:
https://doaj.org/article/e076073440bb424492d68b3e50922502
Autor:
Takuma Otagiri, Yasuhiro Shiga, Takashi Hozumi, Yusuke Matsuura, Ikuko Tajiri, Naoya Takayama, Maria Alejandra, Yuki Shiko, Sumihisa Orita, Kazuhide Inage, Yawara Eguchi, Takane Suzuki, Miyako Suzuki-Narita, Michiaki Mukai, Tomohito Mukaihata, Ryuto Tsuchiya, Soichiro Tokeshi, Kohei Okuyama, Takahito Arai, Noriyasu Toshi, Takeo Furuya, Satoshi Maki, Yasuchika Aoki, Seiji Ohtori
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Platelet-rich plasma (PRP) promotes bone union through osteoinduction. We investigated whether adding demineralized bone matrix (DBM), derived naturally from biomaterial and with various growth factors, for osteoconductivity and bone marrow
Externí odkaz:
https://doaj.org/article/74487a78907149d194eaa032ff9002fc
Autor:
Naoya Takayama, Sachiyo Arai
Publikováno v:
IEEE Access, Vol 11, Pp 58532-58538 (2023)
Several real-world problems are modeled as multi-objective sequential decision-making problems with multiple competing objectives, and multi-objective reinforcement learning (MORL) has garnered attention as a solution to this problem. One of the chal
Externí odkaz:
https://doaj.org/article/a57c072d417c4ae59bfd2506960c5619
Autor:
Naoki Itokawa, Motohiko Oshima, Shuhei Koide, Naoya Takayama, Wakako Kuribayashi, Yaeko Nakajima-Takagi, Kazumasa Aoyama, Satoshi Yamazaki, Kiyoshi Yamaguchi, Yoichi Furukawa, Koji Eto, Atsushi Iwama
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Haematopoietic stem cells (HSCs) exhibit considerable cell-intrinsic changes with age. Here the authors demonstrate that differentially accessible regions in aged HSC chromatin are enriched for stress-responsive enhancers and act as an epigenetic hub
Externí odkaz:
https://doaj.org/article/ab77cfdec83c409e9e21ac09da3b7aa9
Autor:
Masashi Sato, Yasuhiro Shiga, Naoya Takayama, Masamitsu Sone, Kentaro Kosaka, Itsuro Motegi, Norichika Mizuki, Kazuhide Inage, Yawara Eguchi, Miyako Narita, Sumihisa Orita, Koji Eto, Seiji Ohtori
Publikováno v:
Spine Surgery and Related Research, Vol 5, Iss 3, Pp 196-204 (2021)
Introduction: Platelet-rich plasma (PRP) is drawing attention as a substance that can promote bone formation. The growth factors present in PRP are stable for a long time after freeze-drying. However, the effects of PRP are inconsistent, and its effe
Externí odkaz:
https://doaj.org/article/4a7606e248c3411596e3d8d96b8a0b01
Autor:
Hisaya Kato, Yoshiro Maezawa, Yasuo Ouchi, Naoya Takayama, Masamitsu Sone, Kanako Sone, Aki Takada-Watanabe, Kyoko Tsujimura, Masaya Koshizaka, Sayaka Nagasawa, Hisako Saitoh, Manami Ohtaka, Mahito Nakanishi, Hidetoshi Tahara, Akira Shimamoto, Atsushi Iwama, Koji Eto, Koutaro Yokote
Publikováno v:
Stem Cell Research, Vol 53, Iss , Pp 102360- (2021)
Adult progeria Werner syndrome (WS), a rare autosomal recessive disorder, is characterized by accelerated aging symptoms after puberty. The causative gene, WRN, is a member of the RecQ DNA helicase family and is predominantly involved in DNA replicat
Externí odkaz:
https://doaj.org/article/6287b5f3d3414ecf8b91e3511ecf13b2