Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Naoya Shindo"'
Autor:
Naoya Matsunaga, Eriko Ikeda, Keisuke Kakimoto, Miyako Watanabe, Naoya Shindo, Akito Tsuruta, Hisako Ikeyama, Kengo Hamamura, Kazuhiro Higashi, Tomohiro Yamashita, Hideaki Kondo, Yuya Yoshida, Masaki Matsuda, Takashi Ogino, Kazutaka Tokushige, Kazufumi Itcho, Yoko Furuichi, Takaharu Nakao, Kaori Yasuda, Atsushi Doi, Toshiaki Amamoto, Hironori Aramaki, Makoto Tsuda, Kazuhide Inoue, Akio Ojida, Satoru Koyanagi, Shigehiro Ohdo
Publikováno v:
EBioMedicine, Vol 13, Iss C, Pp 262-273 (2016)
Chronic kidney disease (CKD) is a global health problem, and novel therapies to treat CKD are urgently needed. Here, we show that inhibition of G0/G1 switch 2 (G0s2) ameliorates renal inflammation in a mouse model of CKD. Renal expression of chemokin
Externí odkaz:
https://doaj.org/article/78a7228c8a9c43ea90380dcc86ba6101
Autor:
Yuya Hirose, Naoya Shindo, Makiko Mori, Satsuki Onitsuka, Hikaru Isogai, Rui Hamada, Tadanari Hiramoto, Jinta Ochi, Daisuke Takahashi, Tadashi Ueda, Jose M. M. Caaveiro, Yuya Yoshida, Shigehiro Ohdo, Naoya Matsunaga, Shinsuke Toba, Michihito Sasaki, Yasuko Orba, Hirofumi Sawa, Akihiko Sato, Eiji Kawanishi, Akio Ojida
Publikováno v:
Journal of Medicinal Chemistry. 65:13852-13865
The coronavirus disease 2019 (COVID-19) pandemic has necessitated the development of antiviral agents against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). 3C-like protease (3CL
Autor:
Yuya Hirose, Naoya Shindo, Makiko Mori, Satsuki Onitsuka, Hikaru Isogai, Rui Hamada, Tadanari Hiramoto, Jinta Ochi, Daisuke Takahashi, Tadashi Ueda, Jose M.M. Caaveiro, Yuya Yoshida, Shigehiro Ohdo, Naoya Matsunaga, Shinsuke Toba, Michihito Sasaki, Yasuko Orba, Hirofumi Sawa, Akihiko Sato, Eiji Kawanishi, Akio Ojida
The pandemic of coronavirus disease 2019 (COVID-19) has urgently necessitated the development of antiviral agents against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The 3C-like protease (3CLpro) is a promising target for COVID-19 t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3211d9a85a29f192d163952e4dc2eb41
https://doi.org/10.1101/2022.06.05.494897
https://doi.org/10.1101/2022.06.05.494897
Autor:
Shigehiro Ohdo, Naoya Matsunaga, Naoya Shindo, Keiko Kuwata, Akio Ojida, Keisuke Tokunaga, Mami Sato, Satoru Koyanagi, Hirokazu Fuchida, Chizuru Miura
Publikováno v:
Journal of the American Chemical Society. 142:18522-18531
Expanding the repertoire of electrophiles with unique reactivity features would facilitate the development of covalent inhibitors with desirable reactivity profiles. We herein introduce bicyclo[1.1.0]butane (BCB) carboxylic amide as a new class of th
Autor:
Guo Xiao-Lin, Satoru Koyanagi, Keiko Kuwata, Naoya Shindo, Akio Ojida, Hirokazu Fuchida, Keitaro Hosokawa, Mami Sato, Mayumi Ono, Kosuke Watari, Tomohiro Shibata, Shigehiro Ohdo, Naoya Matsunaga, Keisuke Tokunaga, Ryo Inamori
Publikováno v:
ACS Med Chem Lett
[Image: see text] Covalent modification of disease-associated proteins with small molecules is a powerful approach for achieving an increased and sustained pharmacological effect. To reduce the potential risk of nonselective covalent modification, mo
Autor:
Akio Ojida, Naoya Shindo
Publikováno v:
Handbook of In Vivo Chemistry in Mice
Autor:
Rui Hamada, Kenji Mizuguchi, Tadanari Hiramoto, Akio Ojida, Suyong Re, Hikaru Isogai, Daiki Yamane, Satsuki Onitsuka, Naoya Shindo, Eiji Kawanishi
Publikováno v:
Chemical science. 13(10)
The pandemic of COVID-2019 has urged the development of antiviral agents against its causative pathogen SARS-CoV-2. The main protease (Mpro), a cysteine protease essential for viral replication, is a promising protein target. Here we report an irreve
Autor:
Naoya Shindo, Akio Ojida
Publikováno v:
Bioorganicmedicinal chemistry. 47
Covalent drugs exert potent and durable activity by chemical modification of the endogenous target protein in vivo. To maximize the pharmacological efficacy while alleviating the risk of toxicity due to nonspecific off-target reactions, current coval
Autor:
Yuji Hatsuyama, Satoshi Morimoto, Seiichi Sakamoto, Keiko Kuwata, Satoru Koyanagi, Chizuru Miura, Hirokazu Fuchida, Shigehiro Ohdo, Naoya Shindo, Takaharu Nakao, Tomohiro Shibata, Itaru Hamachi, Jose M. M. Caaveiro, Mami Sato, Tomonori Tamura, Tadashi Ueda, Naoya Matsunaga, Mitsunori Shiroishi, Keisuke Tokunaga, Kosuke Watari, Kei Okamoto, Yasuchika Yamaguchi, Mayumi Ono, Akio Ojida, Yoshito Abe
Publikováno v:
Nature Chemical Biology. 15:250-258
Irreversible inhibition of disease-associated proteins with small molecules is a powerful approach for achieving increased and sustained pharmacological potency. Here, we introduce α-chlorofluoroacetamide (CFA) as a novel warhead of targeted covalen
Publikováno v:
Chemicalpharmaceutical bulletin. 68(11)
Fragment-based approach combined with electrophilic reactive compounds is a powerful strategy to discover novel covalent ligands for protein target. However, the promiscuous reactivity often interferes with identification of the fragments possessing