Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Naoya Kakutani"'
Autor:
Takaaki Furihata, Satoshi Maekawa, Shingo Takada, Naoya Kakutani, Hideo Nambu, Ryosuke Shirakawa, Takashi Yokota, Shintaro Kinugawa
Publikováno v:
BMC Pharmacology and Toxicology, Vol 22, Iss 1, Pp 1-10 (2021)
Abstract Background Doxorubicin (DOX) is widely used as an effective chemotherapeutic agent for cancers; however, DOX induces cardiac toxicity, called DOX-induced cardiomyopathy. Although DOX-induced cardiomyopathy is known to be associated with a hi
Externí odkaz:
https://doaj.org/article/8b024ed27fa14a9cafdeeb5dc80db7df
Autor:
Takaaki Furihata, Shingo Takada, Naoya Kakutani, Satoshi Maekawa, Masaya Tsuda, Junichi Matsumoto, Wataru Mizushima, Arata Fukushima, Takashi Yokota, Nobuyuki Enzan, Shouji Matsushima, Haruka Handa, Yoshizuki Fumoto, Junko Nio-Kobayashi, Toshihiko Iwanaga, Shinya Tanaka, Hiroyuki Tsutsui, Hisataka Sabe, Shintaro Kinugawa
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Takaaki Furihata et al. report a new mouse model with heart-specific deletion of the mitochondrial protein, mitoNEET. Their results suggest that loss of mitoNEET expression may contribute to age-associated heart failure in older adults.
Externí odkaz:
https://doaj.org/article/3f63983eae254d919bb87225d2d4c10c
Autor:
Takahiro Abe, Takashi Yokota, Arata Fukushima, Naoya Kakutani, Takashi Katayama, Ryosuke Shirakawa, Satoshi Maekawa, Hideo Nambu, Yoshikuni Obata, Katsuma Yamanashi, Ippei Nakano, Shingo Takada, Isao Yokota, Koichi Okita, Shintaro Kinugawa, Toshihisa Anzai
Publikováno v:
Cardiovascular Diabetology, Vol 19, Iss 1, Pp 1-10 (2020)
Abstract Background Although type 2 diabetes mellitus (T2DM) is one of the most frequent comorbidities in patients with chronic heart failure (CHF), the effects of T2DM on the exercise capacity of CHF patients are fully unknown. Here, we tested the h
Externí odkaz:
https://doaj.org/article/55907e3e25c64eb583466ef8482f1d7b
Autor:
Naoya Kakutani, Shingo Takada, Hideo Nambu, Junichi Matsumoto, Takaaki Furihata, Takashi Yokota, Arata Fukushima, Shintaro Kinugawa
Publikováno v:
Skeletal Muscle, Vol 10, Iss 1, Pp 1-10 (2020)
Abstract Background Transforming growth factor beta (TGF-β)-Smad2/3 is the major signaling pathway of fibrosis, which is characterized by the excessive production and accumulation of extracellular matrix (ECM) components, including collagen. Althoug
Externí odkaz:
https://doaj.org/article/9f3ea013100c4153ba258f1957e6b740
Autor:
Satoshi Maekawa, Shingo Takada, Hideo Nambu, Takaaki Furihata, Naoya Kakutani, Daiki Setoyama, Yasushi Ueyanagi, Dongchon Kang, Hisataka Sabe, Shintaro Kinugawa
Publikováno v:
Cell Communication and Signaling, Vol 17, Iss 1, Pp 1-11 (2019)
Abstract Background Linoleic acid is the major fatty acid moiety of cardiolipin, which is central to the assembly of components involved in mitochondrial oxidative phosphorylation (OXPHOS). Although linoleic acid is an essential nutrient, its excess
Externí odkaz:
https://doaj.org/article/811987f1e75241fc8d0468896cd1625a
Autor:
Masaya Tsuda, Arata Fukushima, Junichi Matsumoto, Shingo Takada, Naoya Kakutani, Hideo Nambu, Katsuma Yamanashi, Takaaki Furihata, Takashi Yokota, Koichi Okita, Shintaro Kinugawa, Toshihisa Anzai
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 9, Iss 5, Pp 844-859 (2018)
Abstract Background Exercise intolerance is a common clinical feature and is linked to poor prognosis in patients with heart failure (HF). Skeletal muscle dysfunction, including impaired energy metabolism in the skeletal muscle, is suspected to play
Externí odkaz:
https://doaj.org/article/5be7a25d485d48ddbf56d267d0f98d0c
Autor:
Naoya Kakutani, Takashi Yokota, Arata Fukushima, Yoshikuni Obata, Taisuke Ono, Takeshi Sota, Yoshiharu Kinugasa, Masashige Takahashi, Hisashi Matsuo, Ryuichi Matsukawa, Ichiro Yoshida, Shigeo Kakinoki, Kazuya Yonezawa, Yoshihiro Himura, Isao Yokota, Kazuhiro Yamamoto, Miyuki Tsuchihashi-Makaya, Shintaro Kinugawa
Publikováno v:
Journal of Cardiology. 79:719-726
Background: The full impact of the intake of citrus fruits on the risk of depression in individuals with chronic heart failure (HF) is unknown. Here, we examined the associations between the estimated habitual intakes of citrus fruits and depressive
Publikováno v:
YAKUGAKU ZASSHI. 142:279-287
The use of flame retardants, namely bis(2,3-dibromopropyl) phosphate (BDBPP) and tris(2,3-dibromopropyl) phosphate (TDBPP), in textile products such as curtains, carpets and sleeping clothes is banned in Japan under the 'Act on the Control of Househo
Autor:
Shigeru, Makita, Takanori, Yasu, Yoshihiro J, Akashi, Hitoshi, Adachi, Hideo, Izawa, Shunichi, Ishihara, Yoshitaka, Iso, Hideo, Ohuchi, Kazuto, Omiya, Yusuke, Ohya, Koichi, Okita, Yutaka, Kimura, Akira, Koike, Masahiro, Kohzuki, Shinji, Koba, Masataka, Sata, Kazunori, Shimada, Tomoki, Shimokawa, Hirokazu, Shiraishi, Naokata, Sumitomo, Tetsuya, Takahashi, Tomoyuki, Takura, Hiroyuki, Tsutsui, Masatoshi, Nagayama, Emiko, Hasegawa, Yoshihiro, Fukumoto, Yutaka, Furukawa, Shin-Ichiro, Miura, Satoshi, Yasuda, Sumio, Yamada, Yuichiro, Yamada, Dai, Yumino, Toshiko, Yoshida, Takuji, Adachi, Toshimi, Ikegame, Kazuhiro P, Izawa, Takeshi, Ishida, Neiko, Ozasa, Naohiko, Osada, Hiroaki, Obata, Naoya, Kakutani, Yusuke, Kasahara, Masaaki, Kato, Kentaro, Kamiya, Shintaro, Kinugawa, Yuji, Kono, Yasuyuki, Kobayashi, Teruyuki, Koyama, Kazuhiro, Sase, Shinji, Sato, Tatsuhiro, Shibata, Norio, Suzuki, Daisuke, Tamaki, Minako, Yamaoka-Tojo, Michio, Nakanishi, Eisaku, Nakane, Mari, Nishizaki, Taiki, Higo, Kanta, Fujimi, Tasuku, Honda, Yasuharu, Matsumoto, Noriko, Matsumoto, Ikuko, Miyawaki, Makoto, Murata, Shusuke, Yagi, Masanobu, Yanase, Midori, Yamada, Miho, Yokoyama, Noboru, Watanabe, Haruki, Ito, Takeshi, Kimura, Syunei, Kyo, Yoichi, Goto, Ryuji, Nohara, Ken-Ichi, Hirata
Publikováno v:
Circulation journal : official journal of the Japanese Circulation Society.
Autor:
Shingo Takada, Satoshi Maekawa, Takaaki Furihata, Naoya Kakutani, Daiki Setoyama, Koji Ueda, Hideo Nambu, Hikaru Hagiwara, Haruka Handa, Yoshizuki Fumoto, Soichiro Hata, Tomoka Masunaga, Arata Fukushima, Takashi Yokota, Dongchon Kang, Shintaro Kinugawa, Hisataka Sabe
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Heart failure (HF) is a leading cause of death and repeated hospitalizations and often involves cardiac mitochondrial dysfunction. However, the underlying mechanisms largely remain elusive. Here, using a mouse model in which myocardial infarction (MI