Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Naoya KIMOTO"'
Autor:
Masako Uchii, Mariko Sakai, Yuhei Hotta, Satoshi Saeki, Naoya Kimoto, Akinori Hamaguchi, Tetsuya Kitayama, Shunji Kunori
Publikováno v:
Journal of Pharmacological Sciences, Vol 135, Iss 3, Pp 126-130 (2017)
Saxagliptin, a potent and selective DPP-4 inhibitor, exhibits a slow dissociation from DPP-4. We investigated the sustained effects of saxagliptin on renal DPP-4 activity in a washout study using renal tubular (HK-2) cells, and in a pharmacodynamic s
Externí odkaz:
https://doaj.org/article/4850ac17a9bd45a3be39b4af856c75ed
Publikováno v:
Journal of Pharmacological Sciences, Vol 132, Iss 1, Pp 65-70 (2016)
Saxagliptin, a potent and selective DPP-4 inhibitor, is characterized by its slow dissociation from DPP-4 and its long half-life and is expected to have a potent tissue membrane-bound DPP-4-inhibitory effect in various tissues. In the present study,
Externí odkaz:
https://doaj.org/article/ee83464ecfb542cdb2fa467b2c83faa8
Autor:
Yuhei Hotta, Shunji Kunori, Satoshi Saeki, Tetsuya Kitayama, Mariko Sakai, Masako Uchii, Naoya Kimoto, Akinori Hamaguchi
Publikováno v:
Journal of Pharmacological Sciences, Vol 135, Iss 3, Pp 126-130 (2017)
Saxagliptin, a potent and selective DPP-4 inhibitor, exhibits a slow dissociation from DPP-4. We investigated the sustained effects of saxagliptin on renal DPP-4 activity in a washout study using renal tubular (HK-2) cells, and in a pharmacodynamic s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1d0ab5a15e9e53d7cf51eb6bc005312
https://doi.org/10.1016/j.jphs.2017.10.003
https://doi.org/10.1016/j.jphs.2017.10.003
Publikováno v:
European Journal of Pharmacology. 783:56-63
Although previous studies have shown an important role of renal dipeptidyl peptidase-4 (DPP-4) inhibition in ameliorating kidney injury in hypertensive rats, the renal distribution of DPP-4 and mechanisms of renoprotective action of DPP-4 inhibition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b961ec02ae45c354ef46d4165f27b67
Autor:
Naoya Kimoto, Yasunori Endo
Publikováno v:
SCIS&ISIS
Clustering is unsupervised classification method in the field of machine learning. c-varieties (CV) and c-regression (CR) are linear clustering that can find linear structures of a dataset. CV and CR are clustering algorithms that perform principal c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b939d84ffa2bd78b45a9482a48d661d
https://doi.org/10.1109/scis-isis.2018.00137
https://doi.org/10.1109/scis-isis.2018.00137
Autor:
Hiroko Sanada, Jyoji Yamate, Kensuke Myojo, Minami Imaizumi, Chie Takada, Yui Suzuki, Itaru Yamaguchi, Katsumi Takaba, Naoya Kimoto
Publikováno v:
Experimental and Toxicologic Pathology. 67:41-51
Common marmosets (Callithrix jacchus) have become a useful animal model, particularly for development of biopharmaceuticals. While various renal failure models have been established in rodents, there is currently no acceptable model in marmosets. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5928180a78d5a1bef534cc10a0ab475e
https://doi.org/10.1016/j.etp.2014.09.007
https://doi.org/10.1016/j.etp.2014.09.007
Autor:
Kensuke Myojo, Itaru Yamaguchi, Chie Takada, Hiroko Sanada, Katsumi Takaba, Minami Imaizumi, Yui Suzuki, Koji Saeki, Atsuko Takami, Naoya Kimoto, Jyoji Yamate
Publikováno v:
Journal of Toxicologic Pathology. 27:183-195
To assess the relevance and availability of subtotal nephrectomized common marmoset monkeys as a chronic renal failure (CRF) model, we observed for 26 weeks the pathophysiological condition of female marmosets subjected to five-sixth surgical nephrec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00e328f941505e691fe774fd9aba82a7
https://doi.org/10.1293/tox.2013-0055
https://doi.org/10.1293/tox.2013-0055
Autor:
Kensuke Myojo, Minami Imaizumi, Tomomi Yoneshige, Eri Sudo, Yui Suzuki, Hiroshi Okumura, Atsuko Takami, Itaru Yamaguchi, Sayaka Ootsuka, Naoya Kimoto, Chie Takada, Koji Saeki, Katsumi Takaba, Hiroko Sanada
Publikováno v:
Journal of Toxicologic Pathology. 26:301-307
We histopathologically and immunohistochemically investigated a case of malignant lymphoma that spontaneously developed in a male common marmoset at two years of age. Beginning at two years four months of age, the animal had an enlargement of the sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4202aefedd407edf2e68f31679ba597
https://doi.org/10.1293/tox.26.301
https://doi.org/10.1293/tox.26.301
Autor:
Hidenori Yahiro, Takahisa Okuwa, Naoya Kimoto, Hirotoshi Sasagawa, Keiko Takiguchi, Makiko Asamoto, Syuhei Yamaguchi
Publikováno v:
Journal of the Ceramic Society of Japan. 121:84-88
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95ae0757139298ce5e47d61042d1cd2a
https://doi.org/10.2109/jcersj2.121.84
https://doi.org/10.2109/jcersj2.121.84
Publikováno v:
Journal of Pharmacological Sciences, Vol 132, Iss 1, Pp 65-70 (2016)
Saxagliptin, a potent and selective DPP-4 inhibitor, is characterized by its slow dissociation from DPP-4 and its long half-life and is expected to have a potent tissue membrane-bound DPP-4-inhibitory effect in various tissues. In the present study,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf08f9f8f9c65dba3da6f103f60fb6b0
https://pubmed.ncbi.nlm.nih.gov/27666017
https://pubmed.ncbi.nlm.nih.gov/27666017