Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Naoya, Asada"'
Autor:
Hirokazu Mishima, Yukihiro Itoh, Takashi Kurohara, Takayoshi Suzuki, Naoya Asada, Ken‐ichi Kusakabe, Yuko Okamoto
Publikováno v:
Journal of Computational Chemistry. 44:1604-1609
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32bb8a93832574088f3e90ab7a2aaec7
https://doi.org/10.1002/jcc.27111
https://doi.org/10.1002/jcc.27111
Autor:
Eiichi Kojima, Atsuhiro Iimuro, Mado Nakajima, Hirotaka Kinuta, Naoya Asada, Yusuke Sako, Zenzaburo Nakata, Kentaro Uemura, Shuhei Arita, Shinobu Miki, Chiaki Wakasa-Morimoto, Yuki Tachibana
Publikováno v:
Journal of Medicinal Chemistry. 65:6157-6170
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47f9735709be42f4cf956b8442fd112d
https://doi.org/10.1021/acs.jmedchem.1c02217
https://doi.org/10.1021/acs.jmedchem.1c02217
Autor:
Naoya Asada, Tatsuhiko Ueno, Shiho Yamamoto, Ken-ichi Kusakabe, Diederik Moechars, Naoki Kanegawa, Harrie J.M. Gijsen, Frederik J. R. Rombouts, Mana Ito, Eriko Matsuoka, Hisanori Ito
Publikováno v:
Journal of Medicinal Chemistry. 64:14165-14174
β-Site amyloid precursor protein-cleaving enzyme 1 (BACE1) is considered to be a promising target for treating Alzheimer's disease. However, all clinical BACE1 inhibitors have failed due to lack of efficacy, and some have even led to cognitive worse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3fba8f14de84d333a48c575bf1fbb2e
https://doi.org/10.1021/acs.jmedchem.1c00359
https://doi.org/10.1021/acs.jmedchem.1c00359
Autor:
Hirokazu Mishima, Takayoshi Suzuki, Yukihiro Itoh, Naoya Asada, Takashi Kurohara, Ken-ichi Kusakabe, Yuko Okamoto
Publikováno v:
Journal of Computational Chemistry; 7/5/2023, Vol. 44 Issue 18, p1604-1609, 6p
Autor:
Yoshifumi Kusumoto, Kyohei Hayashi, Soichiro Sato, Toru Yamada, Iori Kozono, Zenzaburo Nakata, Naoya Asada, Shungo Mitsuki, Ayahisa Watanabe, Chiaki Wakasa-Morimoto, Kentaro Uemura, Shuhei Arita, Shinobu Miki, Tohru Mizutare, Hidenori Mikamiyama
Publikováno v:
ACS medicinal chemistry letters. 13(10)
Human immunodeficiency virus type-1 (HIV-1) protease is essential for viral propagation, and its inhibitors are key anti-HIV-1 drug candidates. In this study, we discovered a novel HIV-1 protease inhibitor (compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce70e02630fb12dc340f6b4e77a44913
https://pubmed.ncbi.nlm.nih.gov/36262395
https://pubmed.ncbi.nlm.nih.gov/36262395
Autor:
Shiho Yamamoto, Hisanori Ito, Takushi Kanazu, Shunsuke Einaru, Shuji Yonezawa, Norihiko Tanimoto, Takahiko Yamamoto, Luc Tritsmans, Takuya Oguma, Akira Kato, Gaku Sakaguchi, Ken-ichi Kusakabe, Katsunori Sakai, Tatsuhiko Ueno, Akihiro Matsuda, Akihiro Hori, Kenji Morimoto, Yoshitaka Yamaguchi, Yoshiyasu Baba, Maarten Timmers, Naoya Asada, Koriyama Yuji
Publikováno v:
Journal of Medicinal Chemistry. 64:1873-1888
Accumulation of amyloid β peptides (Aβ) is thought to be one of the causal factors of Alzheimer's disease (AD). The aspartyl protease β-site amyloid precursor protein cleaving enzyme 1 (BACE1) is the rate-limiting protease for Aβ production, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7261e2c9798f2ee4c20472d855dc9f1
https://doi.org/10.1021/acs.jmedchem.0c01917
https://doi.org/10.1021/acs.jmedchem.0c01917
Autor:
Kazuki Fujimoto, Shigeru Ando, Yutaka Tonomura, Shuhei Yoshida, Harrie J.M. Gijsen, Shiho Yamamoto, Diederik Moechars, Naoki Kanegawa, Frederik J. R. Rombouts, Hisanori Ito, Kouki Fuchino, Shinji Suzuki, Takahiko Yamamoto, Eriko Matsuoka, Genta Tadano, Naoya Asada, Ken-ichi Kusakabe
Publikováno v:
Journal of medicinal chemistry. 64(6)
BACE1 is an attractive target for disease-modifying treatment of Alzheimer's disease. BACE2, having high homology around the catalytic site, poses a critical challenge to identifying selective BACE1 inhibitors. Recent evidence indicated that BACE2 ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b448c0a6e751ca694511c7b88065fd2
https://pubmed.ncbi.nlm.nih.gov/33719429
https://pubmed.ncbi.nlm.nih.gov/33719429
Autor:
Takahiko Yamamoto, Yasuyoshi Iso, Harrie J.M. Gijsen, Tsuyoshi Hasegawa, Tamio Fukushima, Hisanori Ito, Yoshinori Yamano, Ken-ichi Kusakabe, Yasuto Kido, Herman Borghys, Motoko Hosono, Kenji Nakahara, Kouki Fuchino, Yusuke Sako, Shigeru Ando, Naoya Asada, Kazuo Komano, Gaku Sakaguchi, Masayoshi Ogawa, Genta Tadano, Chie Unemura, Deborah Dhuyvetter, Shuichi Ohnishi
Publikováno v:
Journal of Medicinal Chemistry. 61:5525-5546
β-Secretase (BACE1) has an essential role in the production of amyloid β peptides that accumulate in patients with Alzheimer's disease (AD). Thus, inhibition of BACE1 is considered to be a disease-modifying approach for the treatment of AD. Our hit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c0eb137cc2598ec1e3a70b4ec315dc2
https://doi.org/10.1021/acs.jmedchem.8b00011
https://doi.org/10.1021/acs.jmedchem.8b00011
Autor:
Yasuyoshi Iso, Naoki Kanegawa, Vijay Urmaliya, Kazuki Fujimoto, Kazuo Komano, Ard Teisman, An Van Den Bergh, Herman Borghys, Hisanori Ito, Shuhei Yoshida, Shigeru Ando, Yasuto Kido, Nigel E. Austin, Naoya Asada, Shinji Suzuki, Kenji Nakahara, Ken-ichi Kusakabe, Eriko Matsuoka, Harrie J.M. Gijsen, Gaku Sakaguchi, Genta Tadano, Yoshinori Yamano, Tamio Fukushima, Takahiko Yamamoto, Deborah Dhuyvetter, Kouki Fuchino
Publikováno v:
Journal of medicinal chemistry. 62(20)
Genetic evidence points to deposition of amyloid-β (Aβ) as a causal factor for Alzheimer's disease. Aβ generation is initiated when β-secretase (BACE1) cleaves the amyloid precursor protein. Starting with an oxazine lead 1, we describe the discov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b57fbfca1a3d2a869316fa567c087260
https://pubmed.ncbi.nlm.nih.gov/31549838
https://pubmed.ncbi.nlm.nih.gov/31549838
Autor:
Kenji Nakahara, Harrie J.M. Gijsen, Naoki Kanegawa, Genta Tadano, Naoya Asada, Hisanori Ito, Takahiko Yamamoto, Diederik Moechars, Ken-ichi Kusakabe, Eriko Matsuoka, Kouki Fuchino, Kazuki Fujimoto
Publikováno v:
Journal of medicinal chemistry. 62(10)
BACE1 inhibitors hold potential as agents in disease-modifying treatment for Alzheimer's disease. BACE2 cleaves the melanocyte protein PMEL in pigment cells of the skin and eye, generating melanin pigments. This role of BACE2 implies that nonselectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bf16c28ebf3af3e990a7e602dfc9d82
https://pubmed.ncbi.nlm.nih.gov/31021626
https://pubmed.ncbi.nlm.nih.gov/31021626