Výsledky vyhledávání - "Naoual Dahmana"

Polymeric micelle mediated follicular delivery of spironolactone: Targeting the mineralocorticoid receptor to prevent glucocorticoid-induced activation and delayed cutaneous wound healing

Autor: Robert Gurny, Francine Behar-Cohen, Doris Gabriel, Yogeshvar N. Kalia, Laura Kowalczuk, Tatiana Favez, Naoual Dahmana, Thibault Mugnier

Publikováno v: International Journal of Pharmaceutics
International Journal of Pharmaceutics, Elsevier, 2021, pp.120773. ⟨10.1016/j.ijpharm.2021.120773⟩
International Journal of Pharmaceutics, 2021, pp.120773. ⟨10.1016/j.ijpharm.2021.120773⟩
International journal of pharmaceutics, vol. 604, pp. 120773

Impaired wound healing in patients receiving glucocorticoid therapy is a serious clinical concern: mineralocorticoid receptor (MR) antagonists can counter glucocorticoid-induced off-target activation of MR receptors. The aim of this study was to inve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c4ab3600839725eea7ce57d7f0b9cd4
https://hal.sorbonne-universite.fr/hal-03252204/document

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Ocular Biodistribution of Spironolactone after a Single Intravitreal Injection of a Biodegradable Sustained-Release Polymer in Rats

Autor: Naoual Dahmana, Yogeshvar N. Kalia, Laura Kowalczuk, Francine Behar-Cohen, Robert Gurny, Doris Gabriel

Publikováno v: Molecular Pharmaceutics, Vol. 17, No 1 (2020) pp. 59-69

Sustained-release formulations for ocular delivery are of increasing interest given their potential to significantly improve treatment efficacy and patient adherence. The objectives of this study were (i) to develop a sustained-release formulation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02e076219ac88db91770d186cb735533
https://archive-ouverte.unige.ch/unige:138463

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Topical Administration of Spironolactone-Loaded Nanomicelles Prevents Glucocorticoid-Induced Delayed Corneal Wound Healing in Rabbits

Autor: Doris Gabriel, Thierry Bertaim, Vassilios Kaltsatos, Yogeshvar N. Kalia, Thibault Mugnier, Robert Gurny, Naoual Dahmana, Francine Behar-Cohen

Publikováno v: Molecular Pharmaceutics. 15:1192-1202

The objective was to investigate whether mineralocorticoid receptor antagonism using a novel topical micellar formulation of spironolactone could prevent glucocorticoid-induced delayed corneal wound healing in New Zealand white rabbits. Spironolacton

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0b77e7b6820f0f07a010b96b731d1fc
https://doi.org/10.1021/acs.molpharmaceut.7b01028

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Development and validation of a fast and sensitive UHPLC-ESI-MS method for the simultaneous quantification of spironolactone and its metabolites in ocular tissues

Autor: Robert Gurny, Naoual Dahmana, Yogeshvar N. Kalia, Doris Gabriel

Publikováno v: Biomedical Chromatography. 32:e4287

Glucocorticoids are a mainstay for the treatment of immune-mediated conditions and inflammatory diseases. However, their chronic use causes numerous side-effects including delays in corneal and cutaneous wound healing. This is attributed to off-targe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::868d234faabaa0b53874bcf901ff320c
https://doi.org/10.1002/bmc.4287

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