Polymeric micelle mediated follicular delivery of spironolactone: Targeting the mineralocorticoid receptor to prevent glucocorticoid-induced activation and delayed cutaneous wound healing

Autor: Robert Gurny, Francine Behar-Cohen, Doris Gabriel, Yogeshvar N. Kalia, Laura Kowalczuk, Tatiana Favez, Naoual Dahmana, Thibault Mugnier

Publikováno v: International Journal of Pharmaceutics
International Journal of Pharmaceutics, Elsevier, 2021, pp.120773. ⟨10.1016/j.ijpharm.2021.120773⟩
International Journal of Pharmaceutics, 2021, pp.120773. ⟨10.1016/j.ijpharm.2021.120773⟩
International journal of pharmaceutics, vol. 604, pp. 120773

Impaired wound healing in patients receiving glucocorticoid therapy is a serious clinical concern: mineralocorticoid receptor (MR) antagonists can counter glucocorticoid-induced off-target activation of MR receptors. The aim of this study was to inve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c4ab3600839725eea7ce57d7f0b9cd4
https://hal.sorbonne-universite.fr/hal-03252204/document

Topical Administration of Spironolactone-Loaded Nanomicelles Prevents Glucocorticoid-Induced Delayed Corneal Wound Healing in Rabbits

Autor: Doris Gabriel, Thierry Bertaim, Vassilios Kaltsatos, Yogeshvar N. Kalia, Thibault Mugnier, Robert Gurny, Naoual Dahmana, Francine Behar-Cohen

Publikováno v: Molecular Pharmaceutics. 15:1192-1202

The objective was to investigate whether mineralocorticoid receptor antagonism using a novel topical micellar formulation of spironolactone could prevent glucocorticoid-induced delayed corneal wound healing in New Zealand white rabbits. Spironolacton

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0b77e7b6820f0f07a010b96b731d1fc
https://doi.org/10.1021/acs.molpharmaceut.7b01028

Abstract.

Publikováno v: Journal of Interdisciplinary Nanomedicine. Apr2017, Vol. 2 Issue 1, p5-105. 101p.