Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Naoto TOYOTA"'
Autor:
Hirofumi Minomo, Yoshimi Inoue, Takako Iwachido, Hiromi Oota, Koji Otabe, Katsuo Kubono, Satoshi Kondo, Daisuke Sasaki, Yusuke Suzuki, Yuta Nakamura, Hitoshi Naraoka, Masumi Higashiyama, Nozomi Fujisawa, Kumi Honda, Tadao Matsumoto, Hideki Yasui, Yoshiro Saito, Naoto Toyota
Publikováno v:
Bioanalysis. 14:1337-1348
In new drug development, cells or animals are treated with the selected candidate compound to confirm its efficacy and safety in nonclinical studies. Clinical laboratory tests are carried out using samples from experimental animals in these studies.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::100c96c527a4f845ecc2badbf203d45a
https://doi.org/10.4155/bio-2022-0178
https://doi.org/10.4155/bio-2022-0178
Autor:
Nozomi FUJISAWA, Tomochika MATSUSHITA, Saori MATSUO, Mayumi HIRANUMA, Hiroko AZABU, Ryota SAITO, Shun-Ichiro KOMATSU, Atsuhiko KATO, Naoto TOYOTA, Junko TAKETO, Hiromi SUZUKI
Publikováno v:
Experimental Animals; 2024, Vol. 73 Issue 1, p73-82, 10p
Autor:
Naoto Toyota, Mio Hiramatsu, Kazuto Yamashita, Toshihiko Watanabe, Yuichiro Ochiai, Hidetomo Iwano, Atushi Baba, Hiroshi Yokota
Publikováno v:
The Journal of Veterinary Medical Science
Currently, given the concerns regarding animal welfare, it is required that anesthesia or analgesia be used during surgery in experimental animals. Therefore, it is important to understand how anesthesia affects the health conditions of experimental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a74b272c2e2e9e0811a21ca281c214c0
http://hdl.handle.net/10659/00005944
http://hdl.handle.net/10659/00005944
Autor:
Minoru Tsuchitani, Nobuhito Hoshino, Masato Namiki, Hiroshi Iwata, Yumi Wako, Tetsuji Saitoh, Yasuo Ikeda, Ikuo Matsuura, Naoto Toyota, Yoshihito Ishizuka, Einosuke Tani
Publikováno v:
The Journal of Toxicological Sciences. 30:S163-188
A two-generation reproduction toxicity study in rats adding extra endpoints to detect endocrine disrupting activity was conducted using vinclozolin by dietary administration at 0, 40, 200, and 1000 ppm, for investigation of its utility. The extra end
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd80a5dd092bd2dc07c887e730e4f90b
https://doi.org/10.2131/jts.30.s163
https://doi.org/10.2131/jts.30.s163
Autor:
Ikuo, Matsuura, Tetsuji, Saitoh, Einosuke, Tani, Yumi, Wako, Hiroshi, Iwata, Naoto, Toyota, Yoshihito, Ishizuka, Masato, Namiki, Nobuhito, Hoshino, Minoru, Tsuchitani, Yasuo, Ikeda
Publikováno v:
The Journal of Toxicological Sciences. 30:S135-161
A two-generation reproduction toxicity study in rats adding extra endpoints to detect endocrine disrupting activity was conducted using lindane by dietary administration at 0, 10, 60, and 300 ppm, for investigation of its utility. The extra endpoints
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::224cfc61057e57691409beb71a000efa
https://doi.org/10.2131/jts.30.s135
https://doi.org/10.2131/jts.30.s135
Autor:
Michiko Ashina, Masahiro Nasu, Yumi Wako, Takeshi Kanno, Masato Namiki, Naoto Toyota, Hiroko Kokoshima, Yukihiro Nakashima, Minoru Tsuchitani, Takuya Doi, Maimi Tayama
Publikováno v:
Journal of Toxicologic Pathology. 17:197-203
We found spontaneous dwarfs in Wistar Hannover GALAS rats, and morphologically and endocrinologically investigated the endocrine systems. Histologically, little colloid formation, decreased follicular size, and huge vacuoles in the follicular epithel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e0d13d61f04f98184a3f06b868245d3
https://doi.org/10.1293/tox.17.197
https://doi.org/10.1293/tox.17.197
Autor:
Hideaki Hiratsuka, Fumiaki Marumo, Minoru Tsuchitani, Osamu Katsuta, J. Matsumoto, Naoto Toyota, Takashi Umemura, H. Iwata
Publikováno v:
Toxicology and Applied Pharmacology. 126:58-68
The effects of long-term administration of cadmium (Cd) chloride on the bone were studied using ovariectomized rats. The rats were injected iv with the compound at doses of 1.0 and 2.0 mg/kg, 5 days a week, for 13 weeks. The serum concentrations of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9fcaff723bb6defc1926367e88a41f5
https://doi.org/10.1006/taap.1994.1090
https://doi.org/10.1006/taap.1994.1090
Publikováno v:
Experimental animals. 49(2)
Liver biopsy based on a partial hepatectomy technique (shearing) was performed in 10 common marmosets (Callithrix jacchus). This is a preliminary study to evaluate the effects of drugs on hepatic microsomal enzymes: cytochrome P-450 and T4 uridine di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1079b7c9d8f4f9d21d70ef48121ffcde
https://pubmed.ncbi.nlm.nih.gov/10889947
https://pubmed.ncbi.nlm.nih.gov/10889947
Autor:
Masanobu Katoh, Yoshimasa Kurata, Masato Takechi, Naoto Toyota, Seiji Shin-Ya, Minoru Tsuchitani, George M. Rusch, Henry J. Trochimowicz
Publikováno v:
Toxicology letters. 92(3)
Four male and three female marmosets in each group were exposed to air only, 1000 ppm of HCFC 225ca or 5000 ppm of HCFC 225cb, for 6 h per day for 28 consecutive days. HCFC 225ca caused a slight reduction in body weight. HCFC 225cb occasionally cause
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3243894f9c4f3205d36908035795cc7b
https://pubmed.ncbi.nlm.nih.gov/9334832
https://pubmed.ncbi.nlm.nih.gov/9334832
Autor:
T. Akiba, Fumiaki Marumo, Minoru Tsuchitani, Takashi Umemura, Osamu Katsuta, Hideaki Hiratsuka, Naoto Toyota
Publikováno v:
Toxicology and applied pharmacology. 143(2)
To investigate whether chronic exposure of cadmium (Cd) chloride induces osteomalacic lesions similar to Itai-itai disease (IID), ovariectomized rats were injected intravenously with the cadmium at doses of 0.05 and 0.5 mg/kg/day, 5 days per week, fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c34e4131e7119b4ee592764e2bc4c3f0
https://pubmed.ncbi.nlm.nih.gov/9144451
https://pubmed.ncbi.nlm.nih.gov/9144451